Navigation Links
K-State receives patent for noncontroversial source of stem cells
Date:9/7/2010

MANHATTAN, Kan. Kansas State University has been a issued a patent for a plentiful and noncontroversial source of stem cells from a substance in the umbilical cord.

The patent addresses procedures to isolate, culture and bank stem cells found in Wharton's jelly -- the substance that cushions blood vessels in the umbilical cord. These cells are called cord matrix stems cells and are different than those obtained from the blood cells in umbilical cords. The patent is for work by K-State's Mark Weiss and Deryl Troyer, professors of anatomy and physiology; Duane Davis, professor of animal sciences and industry; and former K-State professor Kathy Mitchell. Troyer and Davis were the first to find this previously unidentified source of stem cells.

The patent for Cultures, Products and Methods Using Umbilical Cord Matrix Cells was issued earlier this year to the Kansas State University Research Foundation, or KSURF. The Foundation is a non-profit corporation responsible for managing the technology transfer activities of K-State.

While stem cell research is again stirring debate, the K-State team calls their discovery an effective alternative.

"While there are ethical controversies with stem cells gathered from other tissues in the body, stem cells in Wharton's jelly can be harvested noninvasively and therefore are not controversial," Davis said. Conservatively, the jelly contains well over a million stem cells, he said.

"Any amniote -- that includes birds, reptiles and mammals -- has an umbilical cord or something like it, so this applies to humans as well as animals," Davis said.

In further studies the researchers found the stem cells in Wharton's jelly to be primitive in nature, meaning the cells could undergo more divisions than most adult stem cells, giving them a wide range of regenerative potential. This makes them useful for diverse applications.

The K-State team has explored numerous applications for the stem cells, including using them to repair the nervous system; transporting capsules of anti-cancer drugs directly into tumors; and xenotransplantion of the cells. Each time, the cells have elicited little immune response, meaning they weren't rejected by the host's body, Davis said.

"As far as their role in cancer therapy, they are an excellent weapon," Troyer said. His team has genetically engineered the cells to secrete anti-cancer proteins. He is developing them for delivery of nanomedicines. The team's findings also indicate the cells naturally produce antibodies that make tumors shrink.

"They do have the regenerative potential for joint injuries, and could be used in humans as well as companion animals like dogs, horses and cats, as a way to treat injuries or degenerative diseases and improve the quality of life," Davis said.

Outside of their applications to healing bodily injuries and treating cancer, Troyer and Davis said the potential exists for the cells to be used in delivery of other useful therapeutic molecules, possibly even the delivery of vaccines.

"They also may prove to be a way to deliver very expensive drugs in small amounts to treat specific diseases in cattle or pigs," Davis said. "One thing we've shown is that if you take a newborn pig before it has nursed and administer these cells by mouth, they actually graft in the intestine."

Since the team first published results showing that Wharton's jelly contains stem cells, many publications around the world have appeared, indicating major international interest in potential applications of the cells.


'/>"/>

Contact: Duane Davis
davis@k-state.edu
785-532-1244
Kansas State University
Source:Eurekalert

Related medicine news :

1. K-State research project offers insight into superstitious behavior
2. K-State professors book is first to explore Two-Spirit literature in Northwest native groups
3. K-State Study Finds Abundance of Food Stores, Not Lack of Them, Puts Low-Income Women In Small Cities at Higher Risk of Obesity
4. K-State professor finds link between low oxygen levels in body and cancer-aiding protein
5. St. Jude researcher receives grant to focus on cancer pharmacogenomics in children
6. Penn receives $12 million NIH grant to research personalized approach to smoking cessation
7. Health IT program at the University of Texas at Austin receives $2.7 million in federal funding
8. University of Minnesota math institute receives $20.5 million NSF grant
9. College Of Medicine receives $54 million grant for asthma research
10. Louisiana Tech kinesiology professor receives national editorial excellence award
11. UofL receives $3.15 million grant from Helmsley Charitable Trust
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... in the greater Dallas, Miami, and Raleigh regions, is organizing an extended charity ... a rare and deadly chromosome abnormality. , After struggling since birth with several ...
(Date:10/13/2017)... ... ... As health professionals work to improve their approach to healthcare, there is a ... filling out a survey; in many cases health professionals and patients are working together ... research on the importance of active engagement with patients and members of the public ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's (ABFM) ... and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton ... until Dr. Puffer’s retirement at the end of 2018. Upon assuming the role of ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and ... Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD ... that can be easily incorporated into liquid products, while reducing costs to end users. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Lori R. Somekh, ... member of ElderCounsel, a national organization of elder law and special needs planning attorneys. ... and rules. It also provides a forum to network with elder law attorneys nationwide,” ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... Janssen Biotech, Inc. (Janssen) announced today that ... U.S. Food and Drug Administration (FDA) for the Biologics ... treatment of moderately to severely active rheumatoid arthritis (RA). ... needed to further evaluate the safety of sirukumab in ... "We are disappointed ...
(Date:9/22/2017)... 22, 2017 AVACEN Medical (AVACEN) announced that ... successfully helping those with the widespread pain associated with ... Amanda in Essex, England commented, ... hair, experiencing no sleep at all, tremendous pain, with ... cannot recommend [the AVACEN 100] enough, how this has ...
(Date:9/19/2017)... 2017   ZirMed Inc ., a recognized leader in ... it has been ranked #1 by its users for the ... 2017 User Survey. ZirMed was recognized as the top-ranked end-to-end ... medical centers over 200 beds and holds one of the ... survey history. ...
Breaking Medicine Technology: