Navigation Links
K-State professor finds link between low oxygen levels in body and cancer-aiding protein
Date:3/9/2010

What began as research into how diabetics could possibly preserve their eyesight has led to findings that could prolong the vision of children afflicted with retinoblastoma.

Dolores Takemoto, a Kansas State University professor of biochemistry who was researching protein kinase C gamma in the lens of the human eye, found her work taking a fascinating turn when she discovered a correlation between the protein Coonexin46 and hypoxia -- a deficiency of oxygen which kills normal tissue cells.

According to the data, Coonexin46, or Cx46, appears in the body during these levels of low oxygen. Besides the eye, which is one of the body's only naturally occurring hypoxic tissue, Cx46 also is present in cancer cells since the cells seal themselves off from the oxygen carried by the blood vessels, thus creating a hypoxic environment.

Takemoto believes the findings will lead to serious advancements in treating retinoblastoma, a cancer that forms in the tissue of the retina -- the light-sensitive layers of nerve tissue on the back of the eye. It occurs in 300 U.S. children under the age of 5 each year, according to the National Cancer Institute.

"When a child comes in with retinoblastoma in one eye it's usually too late in the process to save that eye, and, it will spread to the other eye," Takemoto said.

Once an eye becomes cancerous, it has to be removed to prevent the tumor from spreading. Too often, though, Takemoto said, by the time the tumor is noticed in one eye, it has already spread to the second, resulting in a child being permanently blind.

Through her research, Takemoto believes a siRNA medication can be invented which can be injected monthly into the noncancerous eye, preventing tumor growth. siRNA, or small interfering ribonucleic acid, is a class of double-stranded RNA molecules that can be used to interfere with the expression of a specific gene. In this case, the siRNA would suppress Cx46, which allows a tumor to exist in a hypoxic environment. In this manner, the tumor can be prevented from growing at the early hypoxic stage.

Using a mouse model for retinoblastoma, the Takemoto lab has found that use of siRNA to lower the levels of Cx46 will prevent tumor formation.

An international application has been filed with the Patent Cooperation Treaty regarding the findings.

During her trials with Cx46, Takemoto collaborated with Thu Annelise Nguyen, associate professor of toxicology at K-State. The two examined biopsies of MCF-7 breast cancer, where they also found Cx46 present. Takemoto said the same was true for samples of colon cancer.

"Any time there's a drop in oxygen within the body, Cx46 appears," Takemoto said.

While Takemoto's research into Cx46 is focused on the eye, Nguyen is studying Cx46 in breast cancer. She is currently exploring drug discovery and drug testing related to breast cancer.

Besides treating tumors, Takemoto said she believes these findings could help with treatment in acute or chronic heart disease, heart attacks, retinal ischemia, ischemia of the brain, blood pressure problems and glaucoma, as well as for health applications in animals.


'/>"/>

Contact: Dolores Takemoto
dtak@k-state.edu
785-532-7009
Kansas State University
Source:Eurekalert

Related medicine news :

1. Expert on Emerging Infectious Zoonotic Diseases Joining K-State as a Regents Distinguished Professor
2. Professionals in bioscience, food-related industries turn to K-State
3. K-State Veterinary Lab Routinely Tests For Bluetongue Virus; Lab Director Says Strains Found in Kansas, U.S. Usually Less-Virulent
4. K-State Researchers Predict That an Outbreak of Foot-And-Mouth Disease Could Cost Kansas Nearly a Billion Dollars
5. K-State Trauma Researcher Says Being Prepared, Taking Action Are Vital in Preventing Tragedies Like the One at NIU
6. K-State and Kansas Health Foundation Team Up to Promote One Health Kansas
7. K-State Veterinarian Discusses Treating Dogs With Cushings Disease
8. K-State helps nursing home staff become comfortable with residents sexual expression
9. K-State Psychologist Studies Ways to Improve Soldiers Work-Life Relationship
10. K-State engineers create DNA sensors that could identify cancer using material only one atom thick
11. K-State Researcher Finds That the 1918 Spanish Flu Virus Can Infect Swine and Resulted in Current Lineage of H1N1 Swine Influenza Viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's (ABFM) Board ... Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will ... Dr. Puffer’s retirement at the end of 2018. Upon assuming the role of President ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & ... and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to ... with elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Ellevate Network, the ... business to advocate for action towards gender equality at their inaugural Summit in New ... the globe, and reached a social audience of over 3 million. To watch the ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... DevOps and Agile Software Development, has been awarded a contract by the Center ... Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), ... in Las Piedras, Puerto Rico , ... Following a ... sustained minor structural damage, temporary loss of power and ... been completed, manufacturing operations have resumed, and the company ...
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical Services, ... solutions for injectable drug administration, today shared the results ... Adapter for improving the intradermal administration of polio vaccines. ... Vaccination Summit in May 2017 by Dr. Ondrej ... Department, World Health Organization (WHO), and recently published in ...
(Date:10/5/2017)...  In response to the nationwide opioid epidemic, ... (AAOMS) released prescribing recommendations that urge ibuprofen – ... a first-line therapy to manage a patient,s acute ... Recognizing the value and importance of the ... Acute and Postoperative Pain Management" stresses that practitioners ...
Breaking Medicine Technology: