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K-State professor awarded $1.48 million to study LASIK complictions
Date:5/1/2009

Gary Conrad, a university distinguished professor at Kansas State University's Division of Biology, has received a four-year grant renewal of $1.48 million from The National Eye Institute of the National Institutes of Health to study the cornea.

"The NIH renewal will make Conrad's grant the longest continuously funded R01 grant in the state of Kansas at 41 years," said Jim Guikema, K-State associate vice president for research.

From the beginning, Conrad has been fascinated by the unique structure of the cornea.

"Among all body tissues, the cornea is unique in being transparent, very highly innervated, free of blood vessels and yet composed of three layers of living cells," he said.

Conrad's research on embryonic development of the eye has led to knowledge that could possibly improve LASIK surgery. He and his research associates have identified a difference in the connective tissue of normal corneas compared to those that have been cut during LASIK.

LASIK, which stands for laser-assisted in situ keratomileusis, is a surgery using a laser to reshape the cornea as an alternative to wearing glasses or contact lens. During the procedure a thin-hinged flap is cut in the front of the cornea and peeled back out of the way to allow the laser to reshape the corneal connective tissue underneath the flap. When the laser is finished the flap is pulled back to its original position.

"It was once believed that the flap would re-adhere permanently. However, the unique connective tissue of the cornea and a lack of blood vessels limit its ability to fully heal even years after the procedure," Conrad said. "A trauma to the face, such as impact from an automobile air bag provides enough force to dislodge the flap, reopening the cornea, infecting it with dirt and debris, and causing instant loss of visual acuity."

After LASIK, differences in the structure of sugar molecules made the cornea prevent cut nerve ends from r
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Contact: Gary Conrad
gwconrad@k-state.edu
785-532-6662
Kansas State University
Source:Eurekalert

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