Navigation Links
K-State Veterinarian Discusses Treating Dogs With Cushing's Disease

MANHATTAN, Kan., Nov. 4 /PRNewswire-USNewswire/ -- A new medication is available to treat dogs with Cushing's disease, but pet owners should be prepared for the cost of managing the disease, according to a veterinarian at Kansas State University's College of Veterinary Medicine.

Dr. Kenneth Harkin, associate professor of clinical sciences, said a new drug called Trilostane is undergoing approval by the Food and Drug Administration, but veterinarians may obtain the medication if they decide it is the necessary choice to treat Cushing's disease.

The disease is the result of the dog's body producing too much cortisol, the steroid important for the body's stress response. Harkin said excess cortisol is either caused by a tumor of the adrenal gland or, more commonly, of the pituitary gland. He said if the Cushing's disease is caused by an adrenal gland tumor, veterinarians usually try to remove the tumor. If it's a more common pituitary gland tumor, veterinarians rely on medication.

Harkin said Trilostane, which comes in a twice-daily pill, works by inhibiting an enzyme that turns cholesterol into cortisol. This drug presents an alternative to medications that treat Cushing's by destroying the adrenal gland.

The problem with producing too much cortisol, Harkin said, is that it causes muscle wasting, can increase the susceptibility to infection, may delay healing, and, at a minimum, can cause clinical signs that are annoying. These can include excessive thirst and urination, a ravenous appetite, excessive panting and an appearance that is displeasing, such as a potbelly, hair loss and thin skin. The potbellied appearance from Cushing's disease is different than in an obese dog, however.

"An overweight dog will have full hips and back," he said. "With Cushing's, they have muscle loss on the hips and legs, too."

Although the surplus of cortisol is destructive to the dog's body, the excess steroid is making the animal feel quite well.

"You see these dogs with Cushing's disease that look awful, but they feel great," Harkin said.

Cushing's disease, which is not common among humans, is comparatively prevalent in dogs, Harkin said. It's a disease that usually impacts older dogs -- those 8 years old or older -- although dachshunds seem to be particularly vulnerable at a young age, he said.

Although Cushing's is a manageable disease, Harkin said dog owners should be aware that it is costly to treat.

SOURCE Kansas State University
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. K-State and Kansas Health Foundation Team Up to Promote One Health Kansas
2. K-State Trauma Researcher Says Being Prepared, Taking Action Are Vital in Preventing Tragedies Like the One at NIU
3. K-State Researchers Predict That an Outbreak of Foot-And-Mouth Disease Could Cost Kansas Nearly a Billion Dollars
4. K-State Veterinary Lab Routinely Tests For Bluetongue Virus; Lab Director Says Strains Found in Kansas, U.S. Usually Less-Virulent
5. Professionals in bioscience, food-related industries turn to K-State
6. Expert on Emerging Infectious Zoonotic Diseases Joining K-State as a Regents Distinguished Professor
7. Hundreds of Pet Owners Nominate Veterinarians in Nationwide Contest to Find Americas Best Vet
8. Dairy Veterinarians Highlight Need for Improved Methods for Detecting Mastitis
9. Post-Graduate Veterinary Education - Residencies and Internships - Becoming Very Popular Among New Veterinarians
10. Dr. Gail Golab, Head of AVMA Animal Welfare Division, Becomes First U.S. Veterinarian Credentialed in Animal Welfare
11. America Faces Critical Shortage of Veterinarians
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... CBD College ... Allied Health Education Programs (CAAHEP) awarded accreditation to its Diagnostic Medical Sonography program. CBD ... colleges, as only one of twelve colleges and universities in the state of California ...
(Date:11/27/2015)... ... 27, 2015 , ... Avid collector, Andrew Hawley from Vintage Rock Posters, announces ... This is one of Joplin's most famous and beautiful concert posters. The concert was ... in Ann Arbor. The According to Hawley, "It is hard to believe that Joplin's ...
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think Thanksgiving, they also think ... during the Black Friday and Cyber Monday massage chair sales to receive ... high and low to find the best massage chair deals, they can see all ...
(Date:11/26/2015)... ... 2015 , ... The Catalent Applied Drug Delivery Institute today ... dose form selection in early phase drug development. The first of these is ... together the UK’s emerging life sciences companies, corporate partners, and investors, at Milton ...
(Date:11/26/2015)... ... November 26, 2015 , ... WorldCare International, Inc., the ... 61st annual Employee Benefits Conference. The Employee Benefits Conference was hosted by the ... Wednesday, November 11th, 2015. The conference was held at the Hawaii Convention Center ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... Research and Markets ( ) has announced the ... report to their offering. ... author the present scenario and growth prospects of the ... market size, the report considers revenue generated from the ... copper IUDs. The report forecasts the global intrauterine devices ...
(Date:11/26/2015)... , 26 november 2015 AAIPharma ... de geplande investering aan van ten minste ... laboratoria en het mondiale hoofdkantoor in ... zal resulteren in extra kantoorruimte en extra ... de groeiende behoeften van de farmaceutische en ...
(Date:11/26/2015)... Research and Markets ( ) has announced ... Outlook to 2019 - Rise in Cardiac Disorders and Growing ... to their offering. Boston ... scientific and others. --> The market ... Boston scientific and others. ...
Breaking Medicine Technology: