Navigation Links
K-State Researcher, Collaborators Study Virulence of Pandemic H1N1 Virus; Work at K-State Would Protect Pig Industry If the Virus Jumps to Swine Populations
Date:8/3/2009

MANHATTAN, Kan., Aug. 3 /PRNewswire-USNewswire/ -- Laboratory studies at Kansas State University and the work of a K-State researcher are making headway in the effort to control the pandemic H1N1 virus.

Juergen Richt is a Regents Distinguished Professor at K-State's College of Veterinary Medicine and is a Kansas Bioscience Authority Eminent Scholar. His work at K-State and with outside collaborators is revealing the characteristics of the pandemic H1N1 virus.

Richt is among the K-State researchers who study zoonotic disease -- those that can be transmitted from animals to humans and vice versa. Zoonotic diseases will be a focus of the National Agro and Bio-Defense Facility that has been designated for Manhattan.

"Our strength at K-State is that we are very familiar with zoonotic diseases and we can contribute by working on models for animal and human diseases," Richt said. "This expertise is very critical now that an agent causing a pandemic flu in humans most likely originated in animal populations."

At K-State, Richt is leading in vitro research to develop better testing tools, creating a "diagnostic arsenal" if H1N1 were to spread to swine populations. Richt said they are developing diagnostic tools for the direct detection of the virus by finding nucleic acids or other parts of the virus in a sample, as well as tools for indirect detection. The latter approach is done by creating diagnostics that detect antibodies produced by animals infected with the virus.

"We do this work to protect the pig industry in case the virus would jump into the swine population," Richt said.

His work with outside collaborators is testing the virulence of pandemic H1N1 in animal models. In pigs, Richt and his fellow researchers found that pandemic H1N1 does infect pigs and transmits between the animals but is not fatal.

"Its important to know the clinical and pathological effects this virus has on pigs," Richt said. "It is also important to perform these experiments because we produce reagents in the pigs that we use later for diagnostic purposes as controls to validate our testing systems."

The researchers also studied the virulence of two strains of the pandemic H1N1 virus in a nonhuman primate model as a way to predict how the strains would affect humans. Comparing an isolate from California with one from Mexico, Richt and his collaborators found that the California isolate was more virulent than the Mexico isolate. Both pandemic H1N1 viruses are more virulent than seasonal H1N1 flu viruses.

"With different isolates, there are different clinical outcomes," he said.

Establishing animal models for pandemic H1N1 is important, Richt said, because physicians have two types of antiviral medications to treat influenza. One type, called adamantine-like drugs, targets the M2 protein; the other type includes drugs like Tamiflu that target the neuraminidase protein. He said that this pandemic H1N1 is already resistant to the M2 inhibitors but still is sensitive to Tamiflu.

"Some pandemic flu isolates from humans have now shown resistance to the Tamiflu," Richt said. "So the big issue now is if these Tamiflu-resistant strains take over, we have no drug to treat infected patients. And because we don't have a vaccine yet in the United States, this might be a problem.

"Pandemic H1N1 is another example of how important it is to work on the nexus of human and animal health," he said.


'/>"/>
SOURCE Kansas State University
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Pet Bite Injuries: K-State Veterinarian Shares Tips to Minimize Risk of Bites and Bite-Related Infections
2. K-State scientist receives grant from National Institutes of Health to research cataracts
3. K-State Veterinarian Says Although Exotic Pets Can Be Great Companions, There Are Health Factors That Can Affect Both the Animal and Humans
4. Strategies to Rein in Epidemics Need to be Retooled for Rural Populations, Say K-State Engineers Using Computers to Model Disease Outbreaks in Rural Areas
5. K-State Researchers and Their Partners Making it Easier for Rural Kansans of All Ages to Stay Healthy Despite Limited Access to Facilities Like Bike Trails, Gyms
6. K-State professor awarded $1.48 million to study LASIK complictions
7. K-State Researcher Finds That the 1918 Spanish Flu Virus Can Infect Swine and Resulted in Current Lineage of H1N1 Swine Influenza Viruses
8. K-State engineers create DNA sensors that could identify cancer using material only one atom thick
9. K-State Psychologist Studies Ways to Improve Soldiers Work-Life Relationship
10. K-State helps nursing home staff become comfortable with residents sexual expression
11. K-State Veterinarian Discusses Treating Dogs With Cushings Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... Lehi, Utah (PRWEB) , ... May 24, 2017 , ... ... “Super Sick Kids: The Surprising Truth about Pediatric Septic Shock” hosted by the Journal ... 31, 2017, at 2 p.m. Eastern time, will be presented by Captain Rommie Duckworth, ...
(Date:5/24/2017)... ... May 24, 2017 , ... Adelberg-Montalvan ... dentistry options for its patients on Long Island, New York. , Holistic ... being, and is one of the biggest trends in dentistry today. , ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... food ingredient solutions for the food and beverage industry offers Citri-Fi®, a natural ... statements during the purchasing decision process. As a result, labels need to deliver ...
(Date:5/23/2017)... City (PRWEB) , ... May 23, 2017 , ... ... Population Health and Clinical Integration company, announced today that its iClinic V12.2 ... Home (PCMH) 2017 Prevalidation. NCQA recently introduced PCMH 2017 standards which emphasize ...
(Date:5/23/2017)... ... May 23, 2017 , ... PM360, the premier ... today announced the winners of its 3rd Annual ELITE Awards. The ELITE (Exceptional ... in the healthcare industry today. , Out of more than 500 submissions, 100 ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... Mass. and SAN DIEGO ... Obstetricians and Gynecologists (ACOG) 2017 Annual Clinical and Scientific ... single-use, self-contained, illuminating medical devices, today announced the launch ... of its OfficeSPEC and ER-SPEC ... the addition of extra-small and extra-large sizes makes OBP ...
(Date:5/4/2017)... WAYNE, Pa. , May 4, 2017 /PRNewswire/ ... made from thermoplastics and other highly-engineered materials, is ... Microextrusion tubing has been developed in recent ... neurovascular interventional therapies and surgical applications. More expensive ... used to produce microextrusion tubing due to their ...
(Date:5/3/2017)... , May 3, 2017 A Catheterization ... hospital or healthcare facility. Commonly referred to as ... equipped with diagnostic imaging technology to give physicians ... heart. In these spaces, a team of physicians ... angioplasty, percutaneous coronary intervention, congenital heart defect closure, ...
Breaking Medicine Technology: