Navigation Links
'Junk DNA' plays active role in cancer progression, researchers find
Date:5/29/2013

Scientists at The University of Nottingham have found that a genetic rogue element produced by sequences until recently considered 'junk DNA' could promote cancer progression.

The researchers, led by Dr Cristina Tufarelli, in the School of Graduate Entry Medicine and Health Sciences, discovered that the presence of this faulty genetic element known as chimeric transcript LCT13 is associated with the switching off of a known tumour suppressor gene (known as TFPI-2) whose expression is required to prevent cancer invasion and metastasis.

Their findings, published online this month in the journal Nucleic Acid Research, suggest that LCT13 may be involved in switching off TFPI-2.

This faulty genetic element was previously identified by Dr Tufarelli's team as part of a group of chimeric transcripts which are produced by DNA sequences frequently regarded as 'junk DNA' called LINE-1 (L1).

The work reported now expands on the previous observation as it indicates that in addition to acting as potential diagnostic tools these rogue elements can play an active role in cancer.

Dr Tufarelli said: "This study has identified a novel way in which 'junk DNA' can interfere with the normal functioning of a cell. The next step will be to understand how these elements become switched on. This information will be important in the design of treatments aimed to prevent activation of these elements and cancer progression."

The work was initiated through funding by Cancer Research UK, the Royal Society, MRC and Breakthrough Breast Cancer.

A copy of the paper, Expression of a Large LINE-1 Driven Antisense RNA is Linked to Epigenetic Silencing of the Metastasis Suppressor Gene TFPI-2 in Cancer, is available to view online on the website for the journal Nucleic Acid Research.


'/>"/>

Contact: Emma Thorne
emma.thorne@nottingham.ac.uk
44-011-595-15793
University of Nottingham
Source:Eurekalert

Page: 1

Related medicine news :

1. Junk DNA can sense viral infection
2. Geisel researchers sift through junk to find colorectal cancer clues
3. Junk Food Laws in Schools May Mean Healthier Kids: Study
4. Income, screen time affect soda, junk food consumption
5. Junk Food Hurts Your Arteries, But Healthy Meal Might Help
6. Junk Food Taxes Pay Off, Study Finds
7. Gene sequencing project mines data once considered junk for clues about cancer
8. Lack of Sleep May Lead to Junk-Food Bingeing
9. Celebrity endorsement encourages children to eat junk food
10. Maternal diet sets up junk food addiction in babies
11. Do Latex Mattresses Smell? SleepJunkie.org Clears the Air with Latest Article
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... ... (ONS) wanted to create a communications platform that positions them as the go-to ... and ONS reinvented their online publication as an always-on, always-fresh news, views and ...
(Date:3/24/2017)... ... March 24, 2017 , ... Gastro Health (“GH”) ( ... patients for colonoscopy at the HyGIeaCare® Center that is to be located adjacent ... , The HyGIeaCare® Prep, cleared by the U.S. Food and Drug Administration ...
(Date:3/24/2017)... ... , ... “Vintage and Harvest A Cultivation of Christian Love” is the creation ... North Carolina with his wife, Anna Marie. He and his wife are the proud ... also the author of “Shadow and Substance.” , “Love, the agape kind, is seen ...
(Date:3/23/2017)... , ... March 23, 2017 , ... The physicians of ... in the greater Houston Area. The new location is located at 2255 E. Mossy ... in Springwoods Village. This newest location will provide patients living in the north Houston ...
(Date:3/23/2017)... ... ... The MBI “Hall of Fame” recognizes the contributions of those whose careers are or were ... careers of all others involved. , On Monday, March 21st, 2017 Laurie Robert, ... Fame. The induction took place during the World of Modular – Award Gala in ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Strategic Business Report" report to their offering. ... The report provides separate comprehensive analytics for the ... Europe , Asia-Pacific , Latin ... provided for the period 2015 through 2022. Also, a six-year historic analysis ...
(Date:3/24/2017)... -- HealthMine surveys with 9,250 insured consumers fielded from February ... want help from their plans in five key areas: ... 2) help closing gaps in care, 3) better digital ... relevant, real-time guidance. Meeting these needs is essential to ... A Reason to Stay Engaged in Health ...
(Date:3/24/2017)... and GENEVA , March 24, ... World Tuberculosis Day revitalizes efforts to develop sutezolid as ... On World Tuberculosis Day, TB Alliance and the Medicines ... clinical development of sutezolid, an antibiotic drug candidate which ... to the development of sutezolid in combination with other ...
Breaking Medicine Technology: