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'Junk DNA' can sense viral infection
Date:4/24/2012

tion about pathogen and host interactions, we better understand the entire picture. And understanding the reactions of the ncRNA following infection by different viruses can open up the battle against all pathogens."

Finding an "Achilles heel" of infections

The researchers believe that if an ncRNA molecule significantly manifests itself during infection by a particular pathogen, the pathogen has co-opted this ncRNA to help the pathogen devastate the host such as the human body. To help the body fight off the infection, drugs that stop or slow the molecules' proliferation could be a novel and effective strategy.

This new finding allows researchers to develop treatments that attack a virus from two different directions at once, targeting both the coding and non-coding genetic materials, says Dr. Shomron. He suggests that ncRNA could prove to be the "Achilles heel" of pathogens.

Dr. Shomron and his team of researchers developed new software, called RandA, which stands for "ncRNA Read-and-Analyze," that performs ncRNA profiling and analysis on data generated through deep sequencing technology. It's this software that has helped them to uncover the features that characterize virus-infected cells.


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Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

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