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June 2008 highlights
Date:5/23/2008

polychlorinated biphenyls (PCBs) and found that reproductive markers were disrupted not only in the female offspring of these rats, but also in the grand offspring, which are derived from oocytes present in fetuses of the treated females. Changes in the second generation included blunting of preovulatory LH release, reduced progesterone concentrations and reduced uterine weights. The use of low doses of PCBs in this study increases the potential relevance of these findings to reproductive health.

Rebecca M. Steinberg, Deena M. Walker, Thomas E. Juenger, Michael J. Woller, and Andrea C. Gore. Effects of Perinatal Polychlorinated Biphenyls on Adult Female Rat Reproduction: Development, Reproductive Physiology, and Second Generational Effects. Biol Reprod 2008; 78:1091-1101. Published online in BOR-Papers In Press 27 February 2008; DOI 10.1095/biolreprod.107.067249


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Contact: Judith Jansen
bor2@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

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