Navigation Links
June 2008 highlights
Date:5/23/2008

First we knew, then we didn't. A factor, once known as oscillin, carried by sperm into the egg is crucial for promoting the oscillations in free calcium necessary to bring about a cascade of egg activation processes. Phospholipase C zeta (PLCZ1) is a strong candidate for oscillin. Eventually PLCZ1 undergoes nuclear translocation to the zygotes pronuclei where its ability to promote calcium oscillations ceases. One would reasonably think that a factor with such a crucial developmental role would behave commonly in many, if not all vertebrate species. In this case, one would be wrong, as now demonstrated by Ito et al. in a paper on p. 1081 of this issue. This study shows, for example, that PLCZ1 nuclear translocation does not occur in the rat, yet oscillations cease appropriately. Thus mechanisms controlling PLCZ1 translocation and its ability to promote calcium oscillations differ among species. Resolving the molecular bases of these species differences will provide fundamental information on mechanisms governing the initiation of vertebrate embryogenesis.

Masahiko Ito, Tomohide Shikano, Shoji Oda, Takashi Horiguchi, Satomi Tanimoto, Takeo Awaji, Hiroshi Mitani, and Shunichi Miyazaki. Difference in Ca2+ Oscillation-Inducing Activity and Nuclear Translocation Ability of PLCZ1, an Egg-Activating Sperm Factor Candidate, Between Mouse, Rat, Human, and Medaka Fish. Biol Reprod 2008; 78:1081-1090. Published online in BOR-Papers In Press 5 March 2008; DOI 10.1095/biolreprod.108.067801


PCB cocktails for two. Since the 1962 publication of Silent Spring by Rachel Carson, awareness of how environmental toxicants can impact fertility has increased. In an article on p. 1091 of this issue, Steinberg and colleagues provide evidence that adverse reproductive effects of toxicants may extend not only to the children of exposed individuals, but also to the next generation. They treated pregnant rats with a mixture of polychlorinated biphenyls (PCBs) and found that reproductive markers were disrupted not only in the female offspring of these rats, but also in the grand offspring, which are derived from oocytes present in fetuses of the treated females. Changes in the second generation included blunting of preovulatory LH release, reduced progesterone concentrations and reduced uterine weights. The use of low doses of PCBs in this study increases the potential relevance of these findings to reproductive health.

Rebecca M. Steinberg, Deena M. Walker, Thomas E. Juenger, Michael J. Woller, and Andrea C. Gore. Effects of Perinatal Polychlorinated Biphenyls on Adult Female Rat Reproduction: Development, Reproductive Physiology, and Second Generational Effects. Biol Reprod 2008; 78:1091-1101. Published online in BOR-Papers In Press 27 February 2008; DOI 10.1095/biolreprod.107.067249


'/>"/>

Contact: Judith Jansen
bor2@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. REACH Registry Highlights That Patients With Peripheral Arterial Disease (PAD) Suffer High Rates of Heart Attack, Stroke, Hospitalization, and Death
3. Other highlights in the September 11 JNCI
4. NEWSWEEK International Editions: Highlights and Exclusives, Oct. 1, 2007 Issue
5. Georgia Pecans Fit!: New Campaign Highlights Health Benefits, Recipes, Web Site
6. Highlights from the October 2007 Journal of the American Dietetic Association
7. Stereotaxis Highlights New Data on Acute Success in AFib Treatments With Niobe Magnetic Navigation System
8. NEWSWEEK International Editions: Highlights and Exclusives, OCT. 15, 2007 Issue
9. Study Highlights Impact of Chronic Conditions on Working America
10. Report highlights inadequate pandemic planning as a threat to EU security
11. World Bank Group Report on Malaria in Africa Highlights Progress Towards Goal of Significantly Reducing Malaria Deaths
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... The American Board of Family Medicine's (ABFM) Board of ... Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve ... Puffer’s retirement at the end of 2018. Upon assuming the role of President and ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, ... guideline updates for the primary prevention of cardiovascular diseases during the 15th ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... ... 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out ... free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting ... children of all ages; it is a non-competitive, non-timed event, which is all about ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Agile Software Development, has been awarded a contract by the Center for Medicare ... (BPA) aims to accelerate the enterprise use of Agile methodologies in a consistent ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... 2017 AVACEN Medical (AVACEN) announced that its ... helping those with the widespread pain associated with fibromyalgia ... in Essex, England commented, "I ... experiencing no sleep at all, tremendous pain, with every ... recommend [the AVACEN 100] enough, how this has and ...
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)... Sept. 12, 2017  ValGenesis Inc., the global ... is pleased to announce the appointment of Dr. ... its Board of Directors and Chairman of Advisory ... life science companies to manage their entire validation ... paper in this process. Furthermore, ValGenesis VLMS enables ...
Breaking Medicine Technology: