Navigation Links
June 2008 highlights
Date:5/23/2008

First we knew, then we didn't. A factor, once known as oscillin, carried by sperm into the egg is crucial for promoting the oscillations in free calcium necessary to bring about a cascade of egg activation processes. Phospholipase C zeta (PLCZ1) is a strong candidate for oscillin. Eventually PLCZ1 undergoes nuclear translocation to the zygotes pronuclei where its ability to promote calcium oscillations ceases. One would reasonably think that a factor with such a crucial developmental role would behave commonly in many, if not all vertebrate species. In this case, one would be wrong, as now demonstrated by Ito et al. in a paper on p. 1081 of this issue. This study shows, for example, that PLCZ1 nuclear translocation does not occur in the rat, yet oscillations cease appropriately. Thus mechanisms controlling PLCZ1 translocation and its ability to promote calcium oscillations differ among species. Resolving the molecular bases of these species differences will provide fundamental information on mechanisms governing the initiation of vertebrate embryogenesis.

Masahiko Ito, Tomohide Shikano, Shoji Oda, Takashi Horiguchi, Satomi Tanimoto, Takeo Awaji, Hiroshi Mitani, and Shunichi Miyazaki. Difference in Ca2+ Oscillation-Inducing Activity and Nuclear Translocation Ability of PLCZ1, an Egg-Activating Sperm Factor Candidate, Between Mouse, Rat, Human, and Medaka Fish. Biol Reprod 2008; 78:1081-1090. Published online in BOR-Papers In Press 5 March 2008; DOI 10.1095/biolreprod.108.067801


PCB cocktails for two. Since the 1962 publication of Silent Spring by Rachel Carson, awareness of how environmental toxicants can impact fertility has increased. In an article on p. 1091 of this issue, Steinberg and colleagues provide evidence that adverse reproductive effects of toxicants may extend not only to the children of exposed individuals, but also to the next generation. They treated pregnant rats with a mixture of polychlorinated biphenyls (PCBs) and found that reproductive markers were disrupted not only in the female offspring of these rats, but also in the grand offspring, which are derived from oocytes present in fetuses of the treated females. Changes in the second generation included blunting of preovulatory LH release, reduced progesterone concentrations and reduced uterine weights. The use of low doses of PCBs in this study increases the potential relevance of these findings to reproductive health.

Rebecca M. Steinberg, Deena M. Walker, Thomas E. Juenger, Michael J. Woller, and Andrea C. Gore. Effects of Perinatal Polychlorinated Biphenyls on Adult Female Rat Reproduction: Development, Reproductive Physiology, and Second Generational Effects. Biol Reprod 2008; 78:1091-1101. Published online in BOR-Papers In Press 27 February 2008; DOI 10.1095/biolreprod.107.067249


'/>"/>

Contact: Judith Jansen
bor2@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. REACH Registry Highlights That Patients With Peripheral Arterial Disease (PAD) Suffer High Rates of Heart Attack, Stroke, Hospitalization, and Death
3. Other highlights in the September 11 JNCI
4. NEWSWEEK International Editions: Highlights and Exclusives, Oct. 1, 2007 Issue
5. Georgia Pecans Fit!: New Campaign Highlights Health Benefits, Recipes, Web Site
6. Highlights from the October 2007 Journal of the American Dietetic Association
7. Stereotaxis Highlights New Data on Acute Success in AFib Treatments With Niobe Magnetic Navigation System
8. NEWSWEEK International Editions: Highlights and Exclusives, OCT. 15, 2007 Issue
9. Study Highlights Impact of Chronic Conditions on Working America
10. Report highlights inadequate pandemic planning as a threat to EU security
11. World Bank Group Report on Malaria in Africa Highlights Progress Towards Goal of Significantly Reducing Malaria Deaths
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... 24, 2016 , ... The Haute Beauty Network, affiliated with ... as a prominent plastic surgeon and the network’s newest partner. , Dr. ... handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands by ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic ... Frederick area economy by obtaining investment capital for emerging technology companies. SCP ... that have already resulted in more than a million dollars of capital investment ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group ... Tournament held on June 20th at the Woodmont Country Club at 1201 Rockville ... an organization dedicated to helping service members that have been wounded in battle and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
Breaking Medicine Technology: