Navigation Links
June 2008 highlights
Date:5/23/2008

First we knew, then we didn't. A factor, once known as oscillin, carried by sperm into the egg is crucial for promoting the oscillations in free calcium necessary to bring about a cascade of egg activation processes. Phospholipase C zeta (PLCZ1) is a strong candidate for oscillin. Eventually PLCZ1 undergoes nuclear translocation to the zygotes pronuclei where its ability to promote calcium oscillations ceases. One would reasonably think that a factor with such a crucial developmental role would behave commonly in many, if not all vertebrate species. In this case, one would be wrong, as now demonstrated by Ito et al. in a paper on p. 1081 of this issue. This study shows, for example, that PLCZ1 nuclear translocation does not occur in the rat, yet oscillations cease appropriately. Thus mechanisms controlling PLCZ1 translocation and its ability to promote calcium oscillations differ among species. Resolving the molecular bases of these species differences will provide fundamental information on mechanisms governing the initiation of vertebrate embryogenesis.

Masahiko Ito, Tomohide Shikano, Shoji Oda, Takashi Horiguchi, Satomi Tanimoto, Takeo Awaji, Hiroshi Mitani, and Shunichi Miyazaki. Difference in Ca2+ Oscillation-Inducing Activity and Nuclear Translocation Ability of PLCZ1, an Egg-Activating Sperm Factor Candidate, Between Mouse, Rat, Human, and Medaka Fish. Biol Reprod 2008; 78:1081-1090. Published online in BOR-Papers In Press 5 March 2008; DOI 10.1095/biolreprod.108.067801


PCB cocktails for two. Since the 1962 publication of Silent Spring by Rachel Carson, awareness of how environmental toxicants can impact fertility has increased. In an article on p. 1091 of this issue, Steinberg and colleagues provide evidence that adverse reproductive effects of toxicants may extend not only to the children of exposed individuals, but also to the next generation. They treated pregnant rats with a mixture of polychlorinated biphenyls (PCBs) and found that reproductive markers were disrupted not only in the female offspring of these rats, but also in the grand offspring, which are derived from oocytes present in fetuses of the treated females. Changes in the second generation included blunting of preovulatory LH release, reduced progesterone concentrations and reduced uterine weights. The use of low doses of PCBs in this study increases the potential relevance of these findings to reproductive health.

Rebecca M. Steinberg, Deena M. Walker, Thomas E. Juenger, Michael J. Woller, and Andrea C. Gore. Effects of Perinatal Polychlorinated Biphenyls on Adult Female Rat Reproduction: Development, Reproductive Physiology, and Second Generational Effects. Biol Reprod 2008; 78:1091-1101. Published online in BOR-Papers In Press 27 February 2008; DOI 10.1095/biolreprod.107.067249


'/>"/>

Contact: Judith Jansen
bor2@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. REACH Registry Highlights That Patients With Peripheral Arterial Disease (PAD) Suffer High Rates of Heart Attack, Stroke, Hospitalization, and Death
3. Other highlights in the September 11 JNCI
4. NEWSWEEK International Editions: Highlights and Exclusives, Oct. 1, 2007 Issue
5. Georgia Pecans Fit!: New Campaign Highlights Health Benefits, Recipes, Web Site
6. Highlights from the October 2007 Journal of the American Dietetic Association
7. Stereotaxis Highlights New Data on Acute Success in AFib Treatments With Niobe Magnetic Navigation System
8. NEWSWEEK International Editions: Highlights and Exclusives, OCT. 15, 2007 Issue
9. Study Highlights Impact of Chronic Conditions on Working America
10. Report highlights inadequate pandemic planning as a threat to EU security
11. World Bank Group Report on Malaria in Africa Highlights Progress Towards Goal of Significantly Reducing Malaria Deaths
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... Angeles, CA (PRWEB) , ... May 26, 2016 , ... In an effort to provide ... videos available to both Snapchat users and those who do not use the app. Dr. ... on his new page, Dr. Mohebi Live . , Dr. Mohebi says, “The ...
(Date:5/26/2016)... ... 26, 2016 , ... North Cypress Medical Center hosted its 9th ... Cypress. With the help of community partners, the event organizers raised $45,000 for the ... wounded service members and their families through health, wellness, and therapeutic support. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... Power Systems, a ... first PowerWave Instructor Certification Course in Stoughton, Massachusetts. The course was led by ... through the 8 hour interactive course to qualify participants as certified PowerWave trainers. ...
(Date:5/26/2016)... ... May 26, 2016 , ... The introduction of our professional athletes coincides with ... ™”. , “We are proud to introduce Meghan Klingenberg, defender and World ... Brian Quick, wide receiver for Los Angeles who was a second round selection in ...
(Date:5/26/2016)... Las Vegas, NV (PRWEB) , ... May 26, 2016 , ... ... of Ergonomic Tools,” identifies the impact of mobile devices on the billions of users, ... upper backs and necks. While not life threatening, the frequent and common action ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... Dutch surgeons have launched a ground-breaking medical app to help doctors ... a global scale. Medical professionals from Europe , ... the US have already signed up for the app, which combines ... environment. Education  "Imagine a doctor for Medicines ... at Harvard to treat a bomb victim via live streaming - ...
(Date:5/23/2016)... May 23, 2016 According ... Equipment Market by Product (Wheelchair, Scooters, Medical Beds, ... Care, Critical Care, Wound), Accessories (Lifting, Transfer) & ... 2021", published by MarketsandMarkets, the patient handling equipment ... by 2021 at a CAGR of 10.5% during ...
(Date:5/23/2016)... , May 23, 2016 Diplomat Pharmacy, Inc. (NYSE: ... Fellowship and Internship programs. The hands-on learning experience is ... The full-time, paid Fellowship and Internship ... . Fellows and interns are provided optional housing ... Flint at the Riverfront Residence Hall to ...
Breaking Medicine Technology: