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Journal of Clinical Oncology Publishes TREANDA Study Demonstrating Significant Improvement in Overall Response and Progression-Free Survival in Chronic Lymphocytic Leukemia
Date:8/3/2009

he goal of treatment is to stabilize the cancer over the long-term by extending periods of remission," said Prof. Wolfgang Knauf, Onkologische Gemeinschaftspraxis, Frankfurt, Germany and lead investigator of this study. "Treatment options are limited for those with advanced CLL, but this study shows that bendamustine demonstrates significantly better efficacy compared to chlorambucil with a tolerable safety profile."

The study also showed that patients treated with TREANDA had significantly longer PFS compared to chlorambucil (median PFS 21.6 months vs. 8.3 months; p<0.0001). TREANDA was also associated with an improvement in duration of response compared to chlorambucil (21.8 months vs. 8 months). In the study, TREANDA demonstrated a tolerable safety profile; the most common adverse events included myelosuppression, fever, nausea, vomiting and diarrhea. The Clinical Studies section of the TREANDA prescribing information includes complete FDA-approved study information.

About TREANDA

TREANDA, a novel chemotherapy, was approved by the FDA for the treatment of CLL in March 2008. Efficacy relative to other first line therapies other than chlorambucil has not been established. TREANDA received its second approval in October 2008 for the treatment of patients with indolent B-cell non-Hodgkin's lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen.

The following serious adverse reactions have been associated with TREANDA in clinical trials: myelosuppression, infections, infusion reactions and anaphylaxis, tumor lysis syndrome, skin reactions, and other malignancies.

TREANDA has a unique chemical structure that is synthesized to combine an alkylating group and a purine-like benzimidazol
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SOURCE Cephalon, Inc.
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