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Journal of Cardiovascular Electrophysiology Publishes Data Showing Ranolazine Shortened QT Interval and Improved Cardiac Relaxation in Study of Patients With Long QT Syndrome
Date:8/19/2008

- Clinical evidence for unique Ranexa(R) mechanism of action -

PALO ALTO, Calif., Aug. 19 /PRNewswire-FirstCall/ -- CV Therapeutics, Inc. (Nasdaq: CVTX) announced today that the Journal of Cardiovascular Electrophysiology has published a study of ranolazine showing that ranolazine significantly (p<0.001) shortened the QT interval of patients with a hereditary form of long QT syndrome called LQT3. Ranolazine also shortened cardiac relaxation time in the study.

In the study, five patients with LQT3 syndrome were prospectively investigated during an eight hour intravenous infusion of therapeutic concentrations of ranolazine, with ECG and ECHO evaluation before, during and after ranolazine administration.

LQT3 syndrome is caused by a genetic mutation in the late sodium channel and can be associated with heart rhythm problems, including sudden death.

In the study, ranolazine shortened the QT interval by 26 milliseconds in a concentration-dependent manner. Additionally, ranolazine improved diastolic function, as measured by a 13 percent improvement in left ventricular relaxation time. No adverse effects of ranolazine were observed in the study patients.

"These data provide clinical evidence of ranolazine's activity at the late sodium channel and provide important additional information about the very interesting electrophysiological properties of the drug," said Luiz Belardinelli, M.D., senior vice president of pharmacology and translational biomedical research.

In December 2007, the U.S. Food and Drug Administration approved new language for the product labeling for Ranexa(R) (ranolazine extended-release tablets) which describes the ability of ranolazine to inhibit the late sodium current at therape
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SOURCE CV Therapeutics, Inc.
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