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Journal of Alzheimer's Disease special issue explores multifaceted aspects of AD
Date:11/15/2007

ession and psychotic symptoms that occur in a large proportion of AD patients and in the therapeutic effect of drugs currently used.

Cristina Lanni and colleagues from the University of Pavia (Italy) discuss the methodologies that have been used to identify an altered conformational status of p53 in fibroblasts of AD patients. They explain that this alteration may be related to exposure to low amounts of soluble A peptide, not resulting in cytotoxic effects. On this basis, they hypothesize that unfolded p53 could be considered as an agent participating in the early pathogenesis and as a specific marker of the early stage of AD.

Finally, Eugenio Mocchegiani and Marco Malavolta from INRCA (National Institute of Research and Cure for the Elderly) of Ancona (Italy) write about the role of zinc homeostasis in different conditions of brain dysfunction, including brain inflammatory status, aging brain and neurodegeneration They also discuss the role played by metallothioneins (which regulate the intracellular free zinc ions) and 2 macroglobulin (a zinc-binding protein) in aging and AD.


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Contact: Astrid Engelen
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