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Journal of Alzheimer's Disease special issue explores multifaceted aspects of AD
Date:11/15/2007

between normal aging and dementia, with specific attention to possible markers of conversion to dementia.

Ezio Giacobini and Robert Becker from the University of Geneva (Switzerland) expand on possible treatments of AD that should modify the course of the pathological processes at the basis of this disease. Several active and passive vaccines against amyloid- humanized antibody, drugs aiming to reduce tau phosphorylation (GSK3 inhibitors), anti-amyloid-aggregation and anti-APO-E molecules are considered, while the developments of gamma-and beta-secretase inhibitors, due to intrinsic difficulties, seem to have not yet reached the clinical stages.

Clive Ballard and his colleagues Susanne Sorensen and Samantha Sharp from Kings College, London (UK) give a brief overview of the clinical effectiveness of cholinesterase inhibitors for the treatment of Alzheimer's disease, discuss in detail the NICE appraisal of these treatments in the UK as a example of an attempt at a standardized evaluation of cost-effectiveness and argue a proposed way forward to achieve a unified and consistent approach to the assessment of cost-effectiveness for anti-dementia therapies.

Allan Butterfield and Rukhsana Sultana from the University of Kentucky, Lexington (USA) write of their studies on oxidative stress in AD and MCI brain indexed by protein oxidation and lipid peroxidation and summarize findings of oxidatively modified proteins using redox proteomics approach in AD and MCI brain aimed to investigate the mechanism that may be involved in their pathogenesis as well as in terms of MCI progression to AD.

Alessandro Serretti, Paolo Olgiati and Diana De Ronchi, from the University of Bologna (Italy) discuss the genetics of Alzheimer's disease, focusing on the sporadic form in which most genes, related to the amyloid- deposition, oxidative stress and inflammatory response are involved. They report that genetic mechanisms are also involved in expression of depr
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Contact: Astrid Engelen
a.engelen@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

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