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Joslin scientists identify process that affects fat distribution and metabolic syndrome
Date:7/2/2014

ated lipodystrophy. "In some people with HIV, lipodystrophy is so disfiguring that they alter or stop HIV therapy. If we could address the abnormal fat accumulation, people could continue their HIV therapies and get maximal benefit," Dr. Kahn says.

One possible agent that might increase Dicer levels is Rapamycin, an immunosuppressant used to prevent rejection in organ transplantation. Dr. Kahn and Joslin researchers are planning to investigate whether Rapamycin increases Dicer in cellular models.

The Joslin researchers are currently conducting related research to:

  • Learn whether changes in fat tissue alter liver metabolism and muscle tissue and the mechanism that communicates these changes.

  • Determine if miRNAs can serve as therapeutic agents to treat diseases by identifying miRNAs that are deficient and restoring them to normal levels.


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Contact: Jeffrey Bright
jeff.bright@joslin.harvard.edu
Joslin Diabetes Center
Source:Eurekalert  

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