Navigation Links
Joslin scientists identify process that affects fat distribution and metabolic syndrome
Date:7/2/2014

his form of lipodystrophy was also characterized by "whitening" of brown fat cells, a loss of white fat, and signs of metabolic syndrome, including insulin resistance, fat tissue inflammation, dyslipidemia (elevated cholesterol and fat), increased resting energy use, and increased markers of cardiovascular disease.

The researchers also found lower Dicer levels in the fat tissue of patients with HIV and HIV-related lipodystrophy, suggesting that low levels of Dicer expression in fat in HIV patients may contribute to the development of this syndrome, a complication which limits therapy in some people with HIV.

Together, these findings indicate an essential role for Dicer and miRNA processing in white and brown cell differentiation and whole body metabolism that may contribute to the development of HIV-related lipodystrophy. "It's good to build on our previous research on miRNA processing and Dicer in aging and find that a decline in Dicer may also play an important role in HIV lipodystrophy by dramatically changing the biology of fat and the tendency towards diabetes and metabolic syndrome," says lead author C. Ronald Kahn, MD, Chief Academic Officer at Joslin Diabetes Center and the Mary K. Iacocca Professor of Medicine at Harvard Medical School. "This research is a good example of how we go from the "bench" to the bedside and how discoveries in one area or research can lead to insights into other clinical disorders."

This research suggests that therapy with an agent that increases levels of Dicer or specific miRNA expression could be beneficial to people with metabolic syndrome. "If we could increase Dicer activity, fat tissue would have a healthier metabolism which would improve the metabolism of people being treated. It may also reduce the effects of changes in fat that cause insulin resistance and other symptoms of metabolic diseases, such as diabetes," Dr. Kahn says.

Dicer-related therapy might also help patients with HIV-rel
'/>"/>

Contact: Jeffrey Bright
jeff.bright@joslin.harvard.edu
Joslin Diabetes Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Joslin scientists identify important mechanism that affects the aging process
2. Mass. Eye and Ear, Joslin Diabetes announce collaboration in eye care
3. Joslins Susan Bonner-Weir, Ph.D., named American Association for the Advancement of Science Fellow
4. Scientists solving the mystery of human consciousness
5. Scientists uncover multiple faces of deadly breast cancer
6. Scientists identify major source of cells defense against oxidative stress
7. Scientists tailor cell surface targeting system to hit organelle ZIP codes
8. Scientists rewrite rulebook on breast cancer in landmark global study
9. Warwick scientists uncover how checkpoint proteins bind chromosomes
10. NIH scientists link quickly spreading gene to Asian MRSA epidemic
11. Scripps Research scientists show how memory B cells stay in class to fight different infections
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Joslin scientists identify process that affects fat distribution and metabolic syndrome
(Date:10/20/2014)... ASCNYC (ascnyc.org) is a New ... Yorkers living with HIV/AIDS and other chronic conditions ... and self-sufficiency. Each year, ASCNYC spotlights selected “Positive ... their tireless efforts. , Savills Studley ... been selected as this year’s honoree for sharing ...
(Date:10/20/2014)... Ga. (PRWEB) October 20, 2014 ... and relationship-marketing firm, announced today that William H. ... named the 2014 ISE® Luminary Leadership Award winner. ... the achievements of an outstanding leader and industry ... and contributions in advancing the information security industry. ...
(Date:10/20/2014)... Zereana Jess-Huff, a 34-year-old mother, corporate executive and ovarian ... to think outside the bra. She doesn’t try to hide ... awareness about women’s other lady parts. , "We have won ... color pink and everybody knows what you’re talking about,” Jess-Huff ... has not been won when it comes to gynecologic cancers. ...
(Date:10/20/2014)... My Clients Plus ( http://www.MyClientsPlus.com ) ... The new module enables easy administration and routing of ... care. , This application allows users such as Therapists ... a to-do item to a specific client, categorize tasks ... reoccurring reminders for follow-ups. It's designed to enable ...
(Date:10/20/2014)... Diego, CA (PRWEB) October 20, 2014 AttorneyOne.com, ... all the latest information from the FDA on Sit ... on October 10 not to purchase or use Sit and ... Sit and Slim II is promoted as weight loss product ... Sibutramine, removed from the market in 2010 for safety reasons, ...
Breaking Medicine News(10 mins):Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 2Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 2Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 3Health News:My Clients Plus Announces New Workflow Management Software 2Health News:FDA Advises Not to Use Sit and Slim II: AttorneyOne Monitors and Keeps Consumers Informed 2
... , FRIDAY, July 15 (HealthDay News) -- Injection ... treatment, regardless of what types of drugs they use, ... drug users suffer higher rates of abuse, dependence and ... could help treatment programs specialize their care to target ...
... Reporter , FRIDAY, July 15 (HealthDay News) -- New research ... that protects against hundreds of strains of meningococcus B ... Bacterial meningitis, an inflammation of the membranes covering the brain ... vaccines cover four of five types of bacteria that cause ...
... male baboons exhibit higher levels of stress hormones than ... a social hierarchy may be more costly than previously ... researchers, for the first time, identified higher levels of ... to beta males. "These results are very interesting ...
... Reinberg HealthDay Reporter , THURSDAY, July 14 (HealthDay News) ... that include smoking has dropped for the fifth year in a ... nearly 72 percent drop since 2005 in smoking images in movies ... smoking to 595 in 2010. In addition, the average number of ...
... , FRIDAY, July 15 (HealthDay News) -- In an ... number of governments have raised taxes on cigarettes, yet many ... new Canadian study. But the public health measure has ... the researchers recently reported in the International Journal of ...
... and Rome (July 15, 2011): The Lancet , a ... emphasizes the critical role of expanding access to HIV treatment ... pandemic. , The publication of the editorial comment coincides ... Pathogenesis, Treatment and Prevention (IAS 2011) taking place in Rome, ...
Cached Medicine News:Health News:Injection Drug Users Most in Need of Treatment, Study Says 2Health News:Researchers Closer to Developing Universal Meningitis B Vaccine 2Health News:Researchers Closer to Developing Universal Meningitis B Vaccine 3Health News:Less Lighting Up in Movies Aimed at Kids 2Health News:Less Lighting Up in Movies Aimed at Kids 3Health News:Cigarette Tax Unlikely to Deter Some Smokers: Report 2Health News:Roll out treatment as prevention now to stop HIV and AIDS 2
(Date:10/17/2014)... , Oct. 17, 2014  Amgen (NASDAQ: ... Sanders Williams , M.D., president of Gladstone Institutes and ... "We are pleased to welcome Dr. ... Robert A. Bradway , chairman and chief executive ... in academic medicine and his direct experience in our ...
(Date:10/17/2014)... October 17, 2014 ... Market by Technique (Optical Coherence Tomography, Hyperspectral ... Application (Ophthalmology, Neurology, Oncology, Cardiology) - Global ... studies the Optical Imaging market over the ... valued at $917.1 million in 2014 and ...
(Date:10/17/2014)... Md. , Oct. 17, 2014 ... for Medical Technology Policy: The Green ... the FDA, public and private payers, medical device ... clinicians, and other experts January 12, 2015 at ... and value of weight loss treatments.  Participants will ...
Breaking Medicine Technology:Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 3Optical Imaging Market Worth $1,669.2 Million by 2019 2Optical Imaging Market Worth $1,669.2 Million by 2019 3Optical Imaging Market Worth $1,669.2 Million by 2019 4Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2
Used for drainage and retrograde pyelogram in pediatric patients. A stiffening stylet is included to aid in catheter placement. Supplied sterile in peel-open packages. Intended for one-time use....
Used for stenting the urethra during hypospadias or epispadias repair and to promote postoperative drainage of the bladder. Supplied sterile in peel-open packages. Intended for one-time use....
... internal drainage from the ureteropelvic ... sterile in peel-open packages. Intended ... evaluation is advised; polyurethane, C-Flex, ... remain indwelling more than six ...
... the urethra after hypospadias or epispadias ... of the bladder. The externalized portion ... length to allow drainage into a ... inside diaper dry during the healing ...
Medicine Products: