Navigation Links
Joslin scientists identify important mechanism that affects the aging process
Date:5/1/2012

ic regulatory mechanisms.

TOR activity, which is essential for early development but can lead to age-related decline, is implicated in a variety of chronic diseases, including diabetes, cardiovascular disease, cancer and neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. In diabetes, TOR has both positive and negative effects: It promotes beta cell growth and insulin production but inappropriate TORC1 activity leads to insulin resistance and beta cell demise, as well as fat accumulation. At the same time, insufficient TORC2 activity can lead to insulin resistance.

The new results on TOR and SKN-1 suggest that SKN-1 might have a positive effects in Type 2 diabetes: "Turning on this pathway could be important in defending against the effects of high glucose, and promoting beta cell health" says Blackwell.

In the study, TOR activity was inhibited by genetic interference and the TOR-inhibitor rapamycin, a naturally occurring compound which is used as an immunosuppressant in organ transplants, and has been shown to increase lifespan in mice. Using rapamycin or related drugs to treat diseases affected by TOR has been a subject of intense interest among scientists and clinicians. The study found that rapamycin inhibits both TORC1 and TORC2, which will interest scientists investigating rapamycin as a pharmaceutical. "We need to increase understanding of rapamycin and its effects on TOR activity to determine how targeting TOR or processes it controls can help treat diseases that involve TOR and derangement of metabolism. We also need to look at therapies that work on TORC1 and TORC2 independently," said Blackwell. However, one caveat with TOR inhibition is that the kinase plays such a central role in the basic physiology of growing and dividing cells. The new results suggest that in some situations we might want to bypass TOR itself, and directly harness beneficial processes that are controlled by SKN-1 or DAF-16.


'/>"/>
Contact: Jeffrey Bright
jeffrey.bright@joslin.harvard.edu
617-309-1957
Joslin Diabetes Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Joslin scientists identify important mechanism that affects the aging process
(Date:4/1/2015)... (PRWEB) April 01, 2015 NTOCC today ... transitions of care tools that seek to improve care ... this program, NTOCC hopes to bring light to tools ... transitions of care across the healthcare industry through the ... that advance collaborative patient-care. Following that vision, the Knowledge ...
(Date:4/1/2015)... IL (PRWEB) April 01, 2015 ... was joined by other First Spouses from across ... event on March 21, 2015, World Down Syndrome ... for, the rapidly advancing area of Down syndrome ... participating states included Alabama, Alaska, American Samoa, Arizona, ...
(Date:4/1/2015)... Springs, FL (PRWEB) April 01, 2015 ... nation’s leading innovative specialty pharmacies, has released a new ... latest treatment guidelines for treating chronic hepatitis C virus ... treatment guidelines based on information from the American Association ... credible, scientific sources. , Numerous new direct-acting oral medications ...
(Date:4/1/2015)... Dr Roz Kamani, a Vancouver medical aesthetic doctor, ... patients an opportunity to learn more about the latest ... which is an exclusive VIP event conducted three times ... Clinic. It is attended by Dr Roz Kamani’s suppliers ... and services that are on offer. , In ...
(Date:4/1/2015)... April 01, 2015 South Florida’s newest ... Certificate of Authority (PCOA) approval from the State of ... the ongoing development of a retirement community that will ... wellness and spiritual development. , America’s aging population is ... the housing needs of seniors, according to a recent ...
Breaking Medicine News(10 mins):Health News:National Transitions of Care Coalition Launches Knowledge & Resource Center 2Health News:National Transitions of Care Coalition Launches Knowledge & Resource Center 3Health News:Governor First Spouses Join with New Jersey First Lady Mary Pat Christie to Support Advances in Biomedical Research to Treat Down Syndrome Cognitive Impairment 2Health News:BioPlus Specialty Pharmacy Releases ‘HCV Treatment Path’ App for Hepatitis C Providers 2Health News:Dr Roz Kamani Now Offers Patients The Opportunity to Learn About Latest Products and Services 2Health News:Casa Sant’Angelo Receives Approval for New Retirement Living 2
... ... supports on BetterBraces.com. , ... Diego, CA (PRWEB) January 22, 2010 -- DonJoy Velocity ankle braces were the ... total sales of Velocity ankle braces were double that of other ankle supports sold on ...
... factors from younger mice, researchers found , WEDNESDAY, Jan. 27 ... old stem cells in the blood act like young stem ... the aging process. , Taking certain factors from the blood ... old stem cells take on the characteristics of younger stem ...
... is among several that use a variation of MRI ... new imaging technology promises to achieve the long-sought goal ... require the most aggressive treatment, researchers report. , Magnetic ... of suspected cancerous tissue, gave good results in a ...
... ... Florida , ... 2010 -- USA Football, the sport’s national governing body on youth and amateur levels, announced ... list of partners for USA Football’s “Team USA vs. The World” game, presented ...
... CALIFANO CONTINUES AS CHAIRMAN , NEW YORK , ... (CASA) at Columbia University announced today that William H. ... School of Public Service, will become President and Chief Executive Officer ... Califano, Jr. , the former U.S. Secretary of Health, Education, and Welfare ...
... , , WASHINGTON , Jan. 27 ... Washington, D.C. , on Saturday, May 1, 2010 ... The focus of this year,s forum will be expansion and implementation ... the National Board of Certification for Medical Interpreters. , "While medical ...
Cached Medicine News:Health News:DonJoy Velocity Ankle Brace is the Best Selling Ankle Brace in 2009 2Health News:Aging of Blood Stem Cells May Be Reversible 2Health News:New Scan May Help Find Aggressive Prostate Tumors 2Health News:New Scan May Help Find Aggressive Prostate Tumors 3Health News:The Andrews Institute and Reebok Join Partner Roster for USA Football's “Team USA vs. The World” Game, Presented By Riddell 2Health News:The Andrews Institute and Reebok Join Partner Roster for USA Football's “Team USA vs. The World” Game, Presented By Riddell 3Health News:William H. Foster Succeeds Califano as President and CEO of CASA* 2Health News:William H. Foster Succeeds Califano as President and CEO of CASA* 3Health News:William H. Foster Succeeds Califano as President and CEO of CASA* 4Health News:Leaders and Advocates Convene in Washington, D.C. for Fourth Annual National Medical Interpreter Certification - Open Forum 2Health News:Leaders and Advocates Convene in Washington, D.C. for Fourth Annual National Medical Interpreter Certification - Open Forum 3Health News:Leaders and Advocates Convene in Washington, D.C. for Fourth Annual National Medical Interpreter Certification - Open Forum 4
(Date:4/1/2015)... 1, 2015 Jintian Pharmaceutical Group Limited ("Jintian ... Mr. Jin Dongtao, chairman and executive director purchased 40,000,000 ... of the existing entire issued share capital of the ... with the total amount of approximately HK$113 million. Upon ... will increase from 45.17% to 47.17%. ...
(Date:4/1/2015)... 1, 2015  For many businesses and industries just ... the case, having the right management software can be ... better than software solutions company TraxStar Technologies , ... the company announced the release of the newest version ... "QATrax ...
(Date:4/1/2015)... WAYNE, Pa. , April 1, 2015 /PRNewswire/ ... fully integrated specialty pharmaceutical company focused on developing, ... the pricing of an offering of $60.0 million ... due 2020 (the "notes") in a private placement ... under the Securities Act of 1933, as amended ...
Breaking Medicine Technology:Chairman of Jintian Pharmaceutical Purchased Approximately HK$113 Million Worth of Shares Citing Confidence in Company's Development in Online and Offline MacroHealth Business 2Chairman of Jintian Pharmaceutical Purchased Approximately HK$113 Million Worth of Shares Citing Confidence in Company's Development in Online and Offline MacroHealth Business 3Chairman of Jintian Pharmaceutical Purchased Approximately HK$113 Million Worth of Shares Citing Confidence in Company's Development in Online and Offline MacroHealth Business 4Chairman of Jintian Pharmaceutical Purchased Approximately HK$113 Million Worth of Shares Citing Confidence in Company's Development in Online and Offline MacroHealth Business 5TraxStar Technologies Announces Latest QATrax Test Lab Management Software Now Available 2Egalet Announces Proposed $60 Million Offering of Convertible Senior Notes Due 2020 2Egalet Announces Proposed $60 Million Offering of Convertible Senior Notes Due 2020 3Egalet Announces Proposed $60 Million Offering of Convertible Senior Notes Due 2020 4Egalet Announces Proposed $60 Million Offering of Convertible Senior Notes Due 2020 5Egalet Announces Proposed $60 Million Offering of Convertible Senior Notes Due 2020 6Egalet Announces Proposed $60 Million Offering of Convertible Senior Notes Due 2020 7
... , FRANKLIN LAKES, N.J., Dec. 29 ... matrix engineering, announced today that Dr. Shu-Tung Li, the ... as New Jersey,s 2009 Executive of the Year, an ... and Mattia, Certified Public Accountants and Consultants. In ...
... , , , , ... developer of medical device technology for the safe handling, ... Webinar program supporting its culture of safety initiative for ... Culture of Safety in Pharmacy: Lessons Learned," features an ...
Cached Medicine Technology:Shu-Tung Li, Founder and CEO of Collagen Matrix, Inc. Honored as 2009 New Jersey Executive of the Year and Company Named Sixteenth Fastest Growing Company 2Baxa Corporation to Sponsor Free Culture of Safety Webinar 2Baxa Corporation to Sponsor Free Culture of Safety Webinar 3
... Modes of Operation: , Standby: A standby switch ... , Double Burst : 2 60-ms bursts of 50 ... , Twitch: 1 s (1 pulse/s); 2 Hz (2 ... 100 Hz (100 pulses/s) , Train-Of-Four: 4 pulses/2 s; ...
Anesthesia Associates Model 100 Compact Peripheral Nerve Stimulator, incorporates the latest state-of-the-art electronics with solid state cicuitry to ensure trouble-free operation and extended batte...
... original MS-III design the new ... keypad and battery ... MS-IV peripheral nerve stimulator can ... in operating room, post anesthesia ...
... Optilene Mesh LP is a super-light ... The foreign body reaction is reduced considerably. ... mesh for all open hernia repair procedures. ... its excellent flexibility Optilene Mesh LP adapts ...
Medicine Products: