Navigation Links
Joint distraction promotes structural repair in patients with severe knee osteoarthritis

Paris, France, Friday 13 June 2008: Joint distraction (the use of a surgical frame around a degenerated joint to strengthen and promote repair) promotes cartilage repair in severe end stage osteoarthritis (OA) of the knee, as demonstrated for the first time by data presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France.

In the study, an external fixation frame, with springs, was used to bridge the knee joint in 19 relatively young osteoarthritis patients (<60 years). The frame was then distracted by 5mm over a period of two months with the aim of promoting knee repair by removing mechanical stress on the knee. The functional ability and pain scores of the patients were poor before treatment (40% and 30% of the maximum WOMAC score), however, following joint distraction, both scores increased to more than 80%, equivalent to almost complete normalisation in terms of symptoms experienced.

MRI and digital x-ray evaluation carried out at baseline and at one year follow up showed evidence of cartilage repair. Cartilage volume and subchondral bone covered with cartilage increased by 50% and 40% respectively and mean cartilage thickness increased from baseline to one year follow up. Biomarkers of cartilage and bone (breakdown and synthesis), measured in serum and urine, demonstrated an increased level of turnover of cartilage and bone during distraction that returned to normal in the months after treatment, with a gradual increase for cartilage synthesis markers over time indicative of structural repair due to distraction.

Professor Floris Lafeber of the University Medical Center Utrecht, The Netherlands, who led the study, said, "We are delighted to report such an impressive outcome in the use of joint distraction for severe osteoarthritis of the knee. Positive results have been sustained over the two year follow up period, suggesting the potential for joint distraction to delay the need for a joint prosthesis in these relatively young patients. Our data are very promising, demonstrating the clinical efficacy and potential for structural repair. The logical next step should be the implementation of a prolonged prospective multi-centre study on the procedure."

Pain, functional disability, clinical condition and flexion of the joint were evaluated during two years of follow-up using a box-scale, a questionnaire (slightly modified WOMAC), and by physical examination. In addition, serum and urine samples were stored for biomarker evaluation and radiographs and MRIs were taken at regular intervals.

The knee (the largest joint in the body) is a common location for osteoarthritis, which causes painful joint damage and inflammation. This happens because the, as cartilage in the knee gradually roughens and thins, surrounding bone thickens to compensate and the synovium (surrounding membrane) swells, often producing extra fluid. The capsule and ligaments slowly thicken and shrink and muscles can weaken and thin, causing the knee joint to become unstable.

Osteoarthritis of the knee is twice as common in women as in men, mainly occurring in women over the age of 50. So far, no treatment has been available and end stage placement of a joint prosthesis is often inevitable. Delaying such joint replacement surgery and preserving the original joint, specifically in the light of the ageing population, offers significant social and economical potential.


Contact: Rory Berrie
European League Against Rheumatism

Related medicine news :

1. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
2. Joint NJ/NY Rally for Addiction Recovery to Be Hub of Events Nationwide
3. Joint Juice Launches New Ready-to-Drink Glucosamine & Vitamin-Enhanced Dietary Supplement Water Nationwide
4. SAIC Selected to Support the U.S. Military Theater Medical Information Program-Joint
5. The impact of physical activity on weight-bearing knee joint
6. Joint Center Says New Approach Required to Reduce Black Infant Mortality
7. Merlyn Medical Announces FDA Approval for FlexWarmer in a Joint Agreement with Elltec and Suzuken
8. The Joint Commission Enhances Quality Check Website
9. OCS and Press Ganey Partner to Create Joint Analysis of Outcomes and Satisfaction
10. More Damage Than Good? Shock Survey Reveals Sport can Actually be bad for Your Joints
11. Delaware Court Approves Bioenvision, Genzyme Joint Petition
Post Your Comments:
(Date:11/25/2015)... Rouge, LA (PRWEB) , ... November 25, 2015 , ... ... in the United States District Court of Connecticut on behalf of a home health ... behalf of all current or former home health care workers employed by Humana, Inc., ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... is encouraging people across the country to celebrate their sobriety and show through ... to post “before and after” photos this Thanksgiving with the hashtag #FacesOfGratitude on ...
(Date:11/25/2015)... Florida (PRWEB) , ... November 25, 2015 , ... ... testing for physicians and athletic programs, launches new Wimbledon Athletics Facebook ... of testing young athletes for unsuspected cardiac abnormalities. About 2,000 people under the ...
(Date:11/25/2015)... ... November 25, 2015 , ... Smiles by Stevens is pleased to ... facial wrinkling. While many patients are aware of the benefits of Botox® in the ... to those suffering with discomfort, soreness, and pain as a result of Jaw Tension, ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... decades of music, friendships, and learning in its 65th Anniversary Brillianteen Revue, scheduled ... 5-6. , For 65 years, Brillianteen has been a treasured tradition ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... Research and Markets ( ) has announced the ... to 2020" report to their offering. ... the total market share in 2014. The market for ... to growth at the highest CAGR between 2015 and ... fast growing water, industrial gas treatment, pharmaceutical, and food ...
(Date:11/24/2015)... DELHI , November 25, 2015 ... invoked due to repeated failure of IVF cycles. After ... Bhatia was totally dejected and had lost all hopes that she would be ... first Indian miracle child conceived after failure of over ... to abroad (UK) before they decided to take one last attempt ...
(Date:11/24/2015)... Nov. 24, 2015  Natera, Inc. (Nasdaq: ... genetic testing and the analysis of circulating ... present at the 27 th  Annual Piper ... 2015 at 1:00 p.m. ET.  Matthew Rabinowitz, Ph.D., CEO of ... business activities and financial outlook. ...
Breaking Medicine Technology: