Navigation Links
Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
Date:2/18/2010

ta of each patient. To find DNA rearrangements, the team first identified regions where the number of DNA copies was more or less than anticipated and where sections of different chromosomes fused together. These regions were further analyzed to identify DNA sequences displaying incorrect ordering, orientation, or spacing. A range of four to 15 rearrangements were found in each of the six samples.

After investigators identified DNA rearrangements in patients' tumor samples, they looked for the same changes in DNA shed from tumors into the patients' blood. Using blood samples from two of the colorectal cancer patients, they amplified DNA found in the blood and determined that these tests were sensitive enough to detect rearranged tumor DNA in these samples.

Results from such blood tests, they say, could help clinicians detect cancer or its recurrence and inform them on how a patient is responding to cancer therapies. In one colon cancer patient's example, the scientists found a section of chromosome four fused to a section of chromosome eight. "We developed a biomarker that could span this rearrangement and used a blood test to evaluate biomarker levels as the patient received a variety of cancer therapies," says Rebecca Leary, a graduate student at the Johns Hopkins Kimmel Cancer Center.

After an initial surgery, the patient's biomarker levels dropped due to the removal of the majority of the tumor. The biomarker levels rose again, indicating that additional cancer remained in the patient's body. After chemotherapy and a second surgery, levels of the biomarker dropped substantially, but still showed a small but measurable level of the biomarker. This was consistent with a small metastatic lesion that remained in the patient's liver.

The investigators envision that PARE-based biomarkers could also be used to determine whether cancer cells are present in surgical margins or lymph node tissue removed during surgery and possibly for diagnosing e
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Johnson & Johnson to Participate in Bear Stearns 20th Annual Healthcare Conference
2. Draxis Health selected by Johnson and Johnson Consumer Companies, Inc. for major contract manufacturing relationship
3. Johnson & Johnson Campaign for Nursings Future Joins With AACN to Offer New Minority Nurse Faculty Scholars Program
4. Johns Hopkins receives $100 million grant to speed research from clinic to community
5. Trust for Americas Health Receives $7.6 Million Grant from the Robert Wood Johnson Foundation to Advance the Quality and Impact of the Public Health System
6. Deane F. Johnson Center for Neurotherapeutics to Launch First Mobile Medical Unit on October 4th
7. Johnson & Johnson Tops Annual Pharmaceutical Company Rankings in a New Report From Industry-Leading Publication Scrip
8. Independence Technology, A Johnson & Johnson Company, Renews Its Contract With Creative Technology Services
9. In Johnstown Governor Rendell Launches Tour to Insure; Urges Passage of Plan to Give Access to Affordable Health Insurance
10. Johnson & Johnson Launches Global Diabetes Institute to Provide State-of-The- Art Education, Training to Health Professionals
11. Robert Wood Johnson Foundation Announces $15.6 Million Grant to Apply Power of the Archimedes Model to Critical Health Care Decisions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... April 24, 2015 Ryadon is a ... range of capabilities and services to complement any custom ... Quantity Discount Program will be offered on all heavy ... Order 4-19: Receive 10% discount - Order 20+: Receive ... the Drawer Slides Products, Furniture ...
(Date:4/24/2015)... TX (PRWEB) April 24, 2015 The Fastest ... Long, after their great success of the Xtreme Fat Loss ... industry. The fat loss blueprint that claims to help ... the attention of HealthyandFitZone.com's Stan Stevenson, prompting an investigative review. ... shows that the creators spent years researching and experimenting with ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 The 1975 ... toured almost constantly across the globe to theaters, festivals and ... in Manchester, they’ve partnered with their label, Dirty Hit Records, ... Teaming up with the newly launched Cadence & Cause ... their debut LP on vinyl and a signed photo card. ...
(Date:4/24/2015)... 24, 2015 The first step to ... mind. , For meditation and yoga teacher Stine Koppernæs, ... been invaluable tools that allow her to experience more ... has been a teacher since 2006, and through the ... state of being. , “I love sharing this way ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 Carinsurancequotesinfo.com has ... blog post explaining how to qualify for auto ... parents can qualify for auto insurance online, without having ... post explains that single parents can reduce their auto ... released article and properly explained. , Clients can ...
Breaking Medicine News(10 mins):Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3Health News:Fastest Fat Loss Week Ever Review Revealed on Healthy & Fit Zone 2Health News:Internationally Recognized British Indie Rock Outfit The 1975 Partner with Cadence & Cause to Provide Clean Drinking Water to Those in Need 2Health News:Auto Insurance Discounts for Single Parents - How to Qualify for Low Rates 2
... Kennedy To Be Honored for Leadership on Right to Health , ... ... Medical School in Boston, community members and experts join for a landmark ... U.S. and Globally., The event, which commemorates World AIDS Day and the ...
... of a new initiative to create partnerships with pediatric ... has signed a memorandum of understanding with the department ... , The memorandum is the first among Mattel ... Asia and Latin America. , ...
... American application activity for individually underwritten life insurance was down ... Index (SM). Year to date (YTD) U.S. and ... months last year. November,s activity was off -0.9% as ... U.S. application activity was down -1.8% in November ...
... Christmas Story", Ralphie sets out to convince the world that a Red ... "You,ll shoot your eye out!" was the response he got ... more hilarious and memorable quotes from this Christmas classic because we,ve all ... too many people. , , It,s hard ...
... MORTON GROVE, Ill., Dec. 5 Lifeway Foods, Inc.,(Nasdaq: ... today new distribution of its 12 pack "club pack" to the ... addition to the,expansion of the Costco Midwest region from 20 stores ... of December 2008 and consumers can,expect to find the product in ...
... tumors boosts chances for those denied under current protocols, study ... patients with liver cancer who don,t meet criteria used to ... transplantation, according to an Italian study. , The Milan criteria ... 5 centimeters or less in diameter, or three or fewer ...
Cached Medicine News:Health News:Community Unites for Physicians for Human Rights Town Meeting on Global AIDS and Human Rights on December 8 2Health News:Community Unites for Physicians for Human Rights Town Meeting on Global AIDS and Human Rights on December 8 3Health News:Community Unites for Physicians for Human Rights Town Meeting on Global AIDS and Human Rights on December 8 4Health News:Community Unites for Physicians for Human Rights Town Meeting on Global AIDS and Human Rights on December 8 5Health News:Community Unites for Physicians for Human Rights Town Meeting on Global AIDS and Human Rights on December 8 6Health News:MIB Life Index Reports North American Life Insurance Activity Off 1.9% in November 2Health News:Oklahoma Parents Can Prevent Holiday Tragedies with Safe Toys and Celebrations 2Health News:Lifeway Foods Announces New East Coast and Expanded Midwest Distribution 2Health News:New Criteria Could Expand Number of Liver Transplant Candidates 2
(Date:4/24/2015)... -- Allowing more basic emergency medical service (EMS) staff ... involve opioids, according to a Centers for Disease Control ... Emergency Medical Service Providers and the Burden of Drug ... Journal of Public Health . In 2013, ... States involved prescription opioids, and more than ...
(Date:4/24/2015)... 24, 2015  New technologies and online platforms ... educate themselves about products and companies. Likewise, these ... available to market researchers seeking insights into consumer ... it,s imperative that organizations adjust their consumer marketing ... opportunities, niches and growth fronts. ...
(Date:4/24/2015)... 2015 Boston Scientific Corporation (NYSE: BSX ) ... Annual Healthcare Conference on May 6 in ... vice president and chief financial officer, and Susie Lisa ... question and answer session regarding the company with the host ... webcast of the presentation and question and answer session will ...
Breaking Medicine Technology:Expanding Naloxone use could reduce drug overdose deaths and save lives 2Expanding Naloxone use could reduce drug overdose deaths and save lives 3Pharmaceutical Industry Using New Technologies to Adjust Their Marketing and Research Approaches for Consumers 2Boston Scientific To Participate In The Deutsche Bank 40th Annual Healthcare Conference 2
... Calif., April 7, 2011 MEDomics, LLC provides ... medicine in the genomics era and is transforming ... to announce a growth capital investment from our ... from SpaGus will be used by MEDomics to ...
... Pharmaceuticals Inc. today announced that Prabhavathi Fernandes, Ph.D., president ... CHI conferences.  Dr. Fernandes will present at the ... 5 p.m. PDT, April 12, at the Hilton San ... "Macrolides as a New Class of Orally Active Anti-Inflammatory ...
Cached Medicine Technology:MEDomics Announces a Growth Capital Investment from SpaGus Ventures LLC and Gary Augusta Joins MEDomics as Chief Operating Officer 2Cempra Pharmaceuticals to Present at Two Upcoming Cambridge Healthtech Institute (CHI) Conferences 2
... The unique triple-mode technology ... all-around system for an array ... technology includes a patented, controllable ... mode for classical ablation procedures, ...
... is the only in-office test approved by the ... NMP22 BladderChek Test is a painless and non-invasive ... detects elevated levels of NMP22 protein. Healthy individuals ... in the urine. However, the level of NMP22 ...
ARION is a long-pulsed alexandrite laser system with a wavelength of 755 nm...
Used for measuring rectal pressure during urodynamic studies. All-silicone construction provides maximum softness and biocompatibility for enhanced patient comfort. Supplied sterile in peel-open pack...
Medicine Products: