Navigation Links
Johns Hopkins scientists crack genetic code for form of pancreatic cancer
Date:1/21/2011

are individual chemicals called nucleotides, which pair together in a pre-programmed fashion to build DNA and, in turn, a genome. Combinations of these nucleotide letters form genes, which provide instructions that guide cell activity. Changes in the nucleotide pairs, called mutations, can create coding errors that transform a normal cell into a cancerous one.

In the first set of experiments, the Johns Hopkins scientists sequenced nearly all protein-encoding genes in 10 of the 68 samples of pancreatic neuroendocrine tumors and compared these sequences with normal DNA from each patient to identify tumor-specific changes or mutations.

In another set of experiments, the investigators searched through the remaining 58 pancreatic neuroendocrine tumors to determine how often these mutated genes appeared.

The most prevalent mutation, in the MEN-1 gene, occurred in more than 44 percent of all 68 tumors. MEN-1, which has been previously linked to many cancers, creates proteins that regulate how long strands of DNA are twisted and shaped into dense packets that open and close depending on when genes need to be activated. Such a process is regulated by proteins and chemicals that operate outside of genes, termed "epigenetic" by scientists.

Two other commonly mutated genes, DAXX and ATRX, which had not previously been linked to cancer, also have epigenetic effects on how DNA is read. Of the samples studied, mutations in DAXX and ATRX were found in 25 percent and 17.6 percent, respectively. The proteins made by these two genes interact with specific portions of DNA to alter how its chemical letters are read.

"To effectively detect and kill cancers, it may be important to develop new diagnostics and therapeutics that take aim at both epigenetic and genetic processes," says Kenneth Kinzler, Ph.D., professor of oncology at the Johns Hopkins Kimmel Cancer Center and co-director of the Ludwig Center at Johns Hopkins.

The Joh
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hospital shootings rare, but rate of other assults high, Johns Hopkins researchers find
2. Johns Hopkins researchers turn off severe food allergies in mice
3. Kilimani Sesame has positive impact on children in Tanzania: Johns Hopkins University study
4. Pro Ana Versus Pro Recovery Sites: New Study by Johns Hopkins and Stanford University raises concerns.
5. Johns Hopkins provost honored with international award
6. Johns Hopkins to Unveil Center for Biotechnology Education
7. Level of frailty predicts surgical outcomes in older patients, Johns Hopkins researchers find
8. Johns Hopkins School of Medicine enters collaboration with New York Stem Cell Foundation
9. Cancer research award to Johns Hopkins basic scientist
10. Johns Hopkins Health System Acquires Imorgon Ultrasound PACS Product
11. SC Johnson and Bill & Melinda Gates Foundation Unite to Combat Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 2014 Regents Health Resources, a consulting ... brought health care industry veteran Daryl Demonbreun and former ... lead the company’s ambitious plans to grow into a ... been moving along at a steady pace for nearly ... a notch,” says Bob Maier, founder and chief executive ...
(Date:7/29/2014)... 30, 2014 Recently, iFitDress.com, a well-known wedding ... satin bridal gowns . Aside from this, it has ... up to 68 percent off. All of its old and ... The company’s sales representative says excitedly, “We are pleased to ... new range, there are a lot of amazing items. It ...
(Date:7/29/2014)... Dublin, Ireland (PRWEB) July 30, 2014 ... announced the successful completion of a Phase I trial ... Acid (DGLA). , This study was a randomized, placebo-controlled, ... to assess the safety, pharmacokinetics and effect of food ... confirmed the benign safety profile of DGLA following both ...
(Date:7/29/2014)... Johns Hopkins researchers say they have discovered a chemical ... reactions that, if confirmed in larger studies, could give ... person,s risk of attempting suicide. , The discovery, described ... suggests that changes in a gene involved in the ... a significant role in turning what might otherwise be ...
(Date:7/29/2014)... July 29, 2014 Daily Gossip reveals in ... this program claims that he cured his condition with the ... to share part of his experience. , He claimed ... and naturally in just 4 days. Since his method turned ... sufferers from all around the world. , The Nasal ...
Breaking Medicine News(10 mins):Health News:Sferrella and Demonbreun Join Regents Health Resources 2Health News:Cheap Satin Bridal Gowns Recently Provided By Well-known Supplier iFitDress.com 2Health News:DS107G-01 – Successful Completion of Phase I Oral DGLA Clinical Trial 2Health News:A blood test for suicide? 2Health News:A blood test for suicide? 3Health News:Nasal Polyps Treatment Miracle Review Reveals How to Cure Nasal Polyps Without Surgery 2
... HealthDay Reporter , FRIDAY, May 13 (HealthDay News) -- ... to a veterinary clinic near her home in Austin, Texas, when ... like herself," recalled Wong. After running a blood and ... Diabetes is on the rise as America,s cats and dogs grow ...
... in the brains of patients with Alzheimer disease collude, resulting ... cells, according to new findings published online in Neurobiology ... pathological forms of two proteins, amyloid beta and tau, which ... patients plaques and tangles may work in tandem ...
... News) -- Being well-informed about their disease may lead to ... and other emotions about their condition, according to new research. ... were taking medication to manage the disease, and had symptoms ... and abdomen. The women,s coping styles affected their levels ...
... By Dennis Thompson HealthDay Reporter , FRIDAY, May ... the punch line of jokes, prompting chuckles about "mystery meat" ... days, with childhood obesity reaching epidemic proportions in the United ... their kids fit and healthy through proper nutrition. "Five ...
... It,s something we just accept: the fact that the older we ... can leave our ,cars in the same parking lot each morning, ... day, it,s a challenge eight hours later to ,recall whether we ... can ,be introduced to new colleagues at a meeting and will ...
... May 12 (HealthDay News) -- Representatives for veteran TV ... a facility for surgery to remove a meningioma -- ... on the meninges, the brain,s protective outer membrane. ... monitoring this for years, and a neurosurgeon, Mary decided ...
Cached Medicine News:Health News:Fat Cats, Dogs Developing Diabetes, Report Finds 2Health News:Fat Cats, Dogs Developing Diabetes, Report Finds 3Health News:2 defective proteins conspire to impair the nerve cell's 'powerhouse' in Alzheimer's disease 2Health News:2 defective proteins conspire to impair the nerve cell's 'powerhouse' in Alzheimer's disease 3Health News:For Some Women, Knowing About Heart Failure Spurs Worry 2Health News:U.S. Pushes School Cafeterias Toward Healthier Offerings 2Health News:U.S. Pushes School Cafeterias Toward Healthier Offerings 3Health News:As time goes by, it gets tougher to 'just remember this' 2Health News:As time goes by, it gets tougher to 'just remember this' 3Health News:Brain Surgery for Mary Tyler Moore to Remove Benign Tumor 2
(Date:7/29/2014)... N.J. , July 29, 2014 Regado ... company focused on the Phase 3 clinical development of ... controllable antithrombotic drug system, today announced that it will ... Tuesday, Aug. 12, 2014, at 8:30 a.m. EDT to ... highlights. Interested participants and investors may access ...
(Date:7/29/2014)... July 29, 2014  Landauer, Inc. (NYSE: ... radiation measurement and monitoring, outsourced medical physics services and ... for the fiscal third quarter 2014 after the market ... The Company will host a conference call for investors ... Time (10 a.m. Eastern Time). Investors may access the ...
(Date:7/29/2014)... -- New high priced hepatitis C drugs will increase ... $2.9 to $5.8 billion next year, according to a ... by the Pharmaceutical Care Management Association (PCMA). Milliman projects ... much as 8.6 percent in 2015 as a result ... The study finds that the majority of ...
Breaking Medicine Technology:Regado Biosciences to Provide Second Quarter 2014 Financial Results and Corporate Highlights 2Regado Biosciences to Provide Second Quarter 2014 Financial Results and Corporate Highlights 3Landauer, Inc. Sets Date and Time for Announcement of Fiscal Third Quarter 2014 Results 2New Milliman Study: Hepatitis C Drugs Could Increase Medicare Part D Spending by $2.9 to $5.8 Billion in 2015 2
... , SAN CLEMENTE, Calif., Nov. 17 Three ... ages of two through 12 are extremely, very, or ... according to a survey conducted by Opinion Research Corporation ... research of natural remedies including Sinupret® for Kids, a ...
... , DURHAM, N.C., Nov. 17 Oxygen Biotherapeutics, Inc. ... has begun shipping Dermacyte(TM) Oxygen Concentrate Gel to customers ... which are going out today, cover orders received through ... for our company - actually shipping a product to ...
Cached Medicine Technology:Survey Finds Mothers Take Children's Health Into Their Own Hands 2Survey Finds Mothers Take Children's Health Into Their Own Hands 3Survey Finds Mothers Take Children's Health Into Their Own Hands 4Oxygen Biotherapeutics, Inc. Begins Shipping Cosmetic Product to Customers 2
Used to remove wrinkles from sections and for reorientating embedded tissue....
... Plus CO-Oximeter Control (Bayer 800 Series) ... in monitoring the performance of blood ... (Bayer 270 and 800 series) instrumentation. ... on Bayer 800 Rapidlab Series instruments ...
Prevents formation of microscopic ice crystals and sample distortion caused by slow freezing of hyperosmolar tissue samples in conventional cyrostats....
Liquichek Blood Gas Plus CO-Oximeter Control (IL Synthesis Series) is a combination control for use in monitoring the performance of blood gas, ion-selective electrode, biosensor and CO-Oximetry anal...
Medicine Products: