Navigation Links
Johns Hopkins scientists crack genetic code for form of pancreatic cancer
Date:1/21/2011

are individual chemicals called nucleotides, which pair together in a pre-programmed fashion to build DNA and, in turn, a genome. Combinations of these nucleotide letters form genes, which provide instructions that guide cell activity. Changes in the nucleotide pairs, called mutations, can create coding errors that transform a normal cell into a cancerous one.

In the first set of experiments, the Johns Hopkins scientists sequenced nearly all protein-encoding genes in 10 of the 68 samples of pancreatic neuroendocrine tumors and compared these sequences with normal DNA from each patient to identify tumor-specific changes or mutations.

In another set of experiments, the investigators searched through the remaining 58 pancreatic neuroendocrine tumors to determine how often these mutated genes appeared.

The most prevalent mutation, in the MEN-1 gene, occurred in more than 44 percent of all 68 tumors. MEN-1, which has been previously linked to many cancers, creates proteins that regulate how long strands of DNA are twisted and shaped into dense packets that open and close depending on when genes need to be activated. Such a process is regulated by proteins and chemicals that operate outside of genes, termed "epigenetic" by scientists.

Two other commonly mutated genes, DAXX and ATRX, which had not previously been linked to cancer, also have epigenetic effects on how DNA is read. Of the samples studied, mutations in DAXX and ATRX were found in 25 percent and 17.6 percent, respectively. The proteins made by these two genes interact with specific portions of DNA to alter how its chemical letters are read.

"To effectively detect and kill cancers, it may be important to develop new diagnostics and therapeutics that take aim at both epigenetic and genetic processes," says Kenneth Kinzler, Ph.D., professor of oncology at the Johns Hopkins Kimmel Cancer Center and co-director of the Ludwig Center at Johns Hopkins.

The Joh
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hospital shootings rare, but rate of other assults high, Johns Hopkins researchers find
2. Johns Hopkins researchers turn off severe food allergies in mice
3. Kilimani Sesame has positive impact on children in Tanzania: Johns Hopkins University study
4. Pro Ana Versus Pro Recovery Sites: New Study by Johns Hopkins and Stanford University raises concerns.
5. Johns Hopkins provost honored with international award
6. Johns Hopkins to Unveil Center for Biotechnology Education
7. Level of frailty predicts surgical outcomes in older patients, Johns Hopkins researchers find
8. Johns Hopkins School of Medicine enters collaboration with New York Stem Cell Foundation
9. Cancer research award to Johns Hopkins basic scientist
10. Johns Hopkins Health System Acquires Imorgon Ultrasound PACS Product
11. SC Johnson and Bill & Melinda Gates Foundation Unite to Combat Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... Now that Thanksgiving is finally here ... Emassagechair.com has announced its eagerly awaited, once ... , Negotiating on behalf of their customers, and drawing ... Emassagechair.com has generated significant buzz in the industry with ... yet. , Shoppers are excited for significant savings available ...
(Date:11/27/2014)... 27, 2014 VogueQueen.com is making every ... ladies across the world. As the premier online supplier ... is proud to release a huge selection of sexy ... outfits, it is also providing many beautiful styles in ... gowns at discounted prices. , “VogueQueen.com hopes to ...
(Date:11/27/2014)... Viejo, California (PRWEB) November 27, 2014 Developers ... announced a new plugin entitled ProPip, taking FCPX to the ... in picture effect with a few clicks of a mouse,” ... a time saver that our users will appreciate.” , With ... full customization leaving the possibilities truly endless. ProPip is great ...
(Date:11/27/2014)... 27, 2014 HealthPostures, a ... equipment , has announced that it has entered ... Environments. The partnership will put HealthPostures' products into ... , In addition to having its products sold ... promotes HealthPostures' products with the business decision makers ...
(Date:11/27/2014)... At The Little Gym, we know ... as no surprise when a recent study confirmed that ... The Journal of Pediatrics found that “Promoting ... during the school years may be important not only ... study monitored two groups of children; those that were ...
Breaking Medicine News(10 mins):Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 2Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 3Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 4Health News:A New Collection of Sexy Prom Dresses Has Been Released by the Reliable Online Supplier VogueQueen.com 2Health News:Pixel Film Studios released ProPip plugin Exclusively for Final Cut Pro X 2Health News:Pixel Film Studios released ProPip plugin Exclusively for Final Cut Pro X 3Health News:Ergonomics Manufacturer Announces New Partnership with Office Supply Dealer 2
... Post traumatic stress disorder is commonly thought to effect victims ... new University of Georgia study finds that it also can ... such as cancer. , The finding, scheduled to be published ... Social Work Practice, has major implications for helping children cope ...
... 2008, to be Proclaimed Light San Diego Pink Day, ... Komen for the Cure,the world,s largest grassroots network of ... forever, announced today that,its San Diego Affiliate will award ... help the uninsured and underinsured women and men in,San ...
... 8, 2008 Costs are rising on,everything from bread to ... every time a nurse visits a Medicaid patient in the ... assistance reimbursement,increase is clear, according to nurses and other home ... in the state,Capitol., The cost of a nurse,s visit ...
... Run Campaign to Support Jimmy Fund and ... Children,s Hospital Boston, ... home runs this baseball season will help support,children with medical needs ... Hess Corporation will donate $500 for every home run hit during ...
... Nonin Medical, Inc., in an,effort to ... use of remote,monitoring, unveiled the world,s first ... American Telemedicine Association (ATA) meeting,in Seattle, WA. ... pulse,oximeter is designed for interoperability, meeting the ...
... Experience on eBay, CHICAGO, April 8, 2008 ... the captain,s seat in the fight against cancer.,In ... is auctioning off a,behind-the-scenes tour and flight simulator ... Denver, Colo., including two domestic,roundtrip tickets to Denver ...
Cached Medicine News:Health News:Study: Treating post-traumatic stress first helps children overcome grief 2Health News:Study: Treating post-traumatic stress first helps children overcome grief 3Health News:Susan G. Komen for the Cure Awards San Diego Organizations Nearly $1 Million to Fight Breast Cancer 2Health News:Susan G. Komen for the Cure Awards San Diego Organizations Nearly $1 Million to Fight Breast Cancer 3Health News:Susan G. Komen for the Cure Awards San Diego Organizations Nearly $1 Million to Fight Breast Cancer 4Health News:Bayada Nurses Advocates for Increase in Medicaid Reimbursement Rate to Allow More Individuals to Receive Home Care and Hire More Skilled Staff 2Health News:Every Boston Red Sox Home Run Televised on NESN in 2008 to Help Children With Medical Needs 2Health News:Every Boston Red Sox Home Run Televised on NESN in 2008 to Help Children With Medical Needs 3Health News:Advancing Interoperability - Nonin(R) Medical Unveils World's First Bluetooth(R)-Enabled, Wireless Fingertip Pulse Oximeter 2Health News:Be in the Captain's Seat in the Fight Against Cancer 2Health News:Be in the Captain's Seat in the Fight Against Cancer 3
(Date:11/26/2014)... FRANCISCO , Nov. 25, 2014  goBalto, Inc., ... has been recognized as a winner of Red Herring,s ... a Global Top 100 North America award in 2013, ... international technology landscape. Red Herring,s Top 100 ... identifying promising new companies and entrepreneurs. Red Herring editors ...
(Date:11/26/2014)... 25, 2014 Nanomix Inc., (Nanomix), ... development of mobile diagnostic tests to enable ... and pre-hospital settings, today announced it has ... The certification was awarded by the British ... leading certification bodies. ISO ...
(Date:11/26/2014)... BOULDER, Colo. , Nov. 25, 2014 ... ARRY ) today announced that its Chief ... speak at the following upcoming conferences.  The ... conferences through webcasts on the Array BioPharma ... ConferenceDate:Wednesday, December 3, 2014Time:1:30 p.m.  Eastern Time ...
Breaking Medicine Technology:goBalto Selected as a 2014 Red Herring Top 100 Global Company 2goBalto Selected as a 2014 Red Herring Top 100 Global Company 3Nanomix Receives ISO 13485:2003 Certification 2
... CONCORD, N.H., Oct. 5 A new statewide prescription assistance ... New Hampshire Rx Card will offer savings of up to ... across the country. All New Hampshire residents are eligible to ... can download a "FREE" card by visiting www.nhrxcard.com ...
... 5 BioWa, Inc. announced today that it ... Co. Ltd. (Otsuka) to provide Otsuka with access ... development and commercialization of their antibody therapeutics with ... Japanese pharmaceutical POTELLIGENT® License was initiated in May, ...
Cached Medicine Technology:New Hampshire Rx Card Launching Statewide 2BioWa Announces Second Japanese License of POTELLIGENT(R) Technology to Otsuka Pharmaceutical 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: