Navigation Links
Johns Hopkins scientists crack genetic code for form of pancreatic cancer
Date:1/21/2011

are individual chemicals called nucleotides, which pair together in a pre-programmed fashion to build DNA and, in turn, a genome. Combinations of these nucleotide letters form genes, which provide instructions that guide cell activity. Changes in the nucleotide pairs, called mutations, can create coding errors that transform a normal cell into a cancerous one.

In the first set of experiments, the Johns Hopkins scientists sequenced nearly all protein-encoding genes in 10 of the 68 samples of pancreatic neuroendocrine tumors and compared these sequences with normal DNA from each patient to identify tumor-specific changes or mutations.

In another set of experiments, the investigators searched through the remaining 58 pancreatic neuroendocrine tumors to determine how often these mutated genes appeared.

The most prevalent mutation, in the MEN-1 gene, occurred in more than 44 percent of all 68 tumors. MEN-1, which has been previously linked to many cancers, creates proteins that regulate how long strands of DNA are twisted and shaped into dense packets that open and close depending on when genes need to be activated. Such a process is regulated by proteins and chemicals that operate outside of genes, termed "epigenetic" by scientists.

Two other commonly mutated genes, DAXX and ATRX, which had not previously been linked to cancer, also have epigenetic effects on how DNA is read. Of the samples studied, mutations in DAXX and ATRX were found in 25 percent and 17.6 percent, respectively. The proteins made by these two genes interact with specific portions of DNA to alter how its chemical letters are read.

"To effectively detect and kill cancers, it may be important to develop new diagnostics and therapeutics that take aim at both epigenetic and genetic processes," says Kenneth Kinzler, Ph.D., professor of oncology at the Johns Hopkins Kimmel Cancer Center and co-director of the Ludwig Center at Johns Hopkins.

The Joh
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hospital shootings rare, but rate of other assults high, Johns Hopkins researchers find
2. Johns Hopkins researchers turn off severe food allergies in mice
3. Kilimani Sesame has positive impact on children in Tanzania: Johns Hopkins University study
4. Pro Ana Versus Pro Recovery Sites: New Study by Johns Hopkins and Stanford University raises concerns.
5. Johns Hopkins provost honored with international award
6. Johns Hopkins to Unveil Center for Biotechnology Education
7. Level of frailty predicts surgical outcomes in older patients, Johns Hopkins researchers find
8. Johns Hopkins School of Medicine enters collaboration with New York Stem Cell Foundation
9. Cancer research award to Johns Hopkins basic scientist
10. Johns Hopkins Health System Acquires Imorgon Ultrasound PACS Product
11. SC Johnson and Bill & Melinda Gates Foundation Unite to Combat Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... One of the most popular vaccine brands for ... doctors may be overlooking some cost factors when choosing ... more expensive option, according to a new study by ... to administer can be driven by numerous factors," says ... a professor of computer science and of mathematics at ...
(Date:4/17/2014)... published in the April issue of Immunity , ... for Medical Research, says it,s time to take a ... treating sepsis, which kills millions worldwide every year, ... molecules released into the bloodstream to fight an injury ... necessary for maintaining good health without inflammation, wounds ...
(Date:4/17/2014)... estimated that as many as 10 million older Americans ... loneliness and isolation. , However, new research a ... older Americans for six years found that Internet ... depression by more than 30 percent. , "That,s a ... University professor of telecommunication, information studies and media who ...
(Date:4/17/2014)... YORK April 17, 2014 EcoHealth Alliance, a ... health issues, published a comprehensive review today examining the ... Marburg virus. The review calls for improved global surveillance ... as the recent outbreak of Ebola in West Africa ... the countries of Guinea and Liberia. According to ...
(Date:4/17/2014)... a colored ribbon representing a disease. A pink ribbon is ... does one think of with lung cancer?, Although white has ... the disease, black may be the only one they think ... patients, primarily smokers between the ages of 51 to 79 ... felt by these patients, the emotional toll it can have ...
Breaking Medicine News(10 mins):Health News:Study recalculates costs of combination vaccines 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Internet use can help ward off depression among elderly 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3Health News:Unraveling the 'black ribbon' around lung cancer 2
... successfully isolated nanoparticles from human kidney stones in cell ... to be associated with nanoparticles. ,The findings, ... of Investigative Medicine, are significant because it is one ... are viable living forms that can lead to disease ...
... Research Service (ARS) scientists have reported that the newly ... to produce flour with 25% more magnesium than commercial ... of the ARS Soft Wheat Quality Research Unit at ... M. Peterson at the University of Idaho Research and ...
... shock and disappointment on hearing the news about a ... five Bulgarian nurses and one Palestinian doctor for supposedly ... ,George Bush has expressed his "disappointment" to Georgi Parvanov, ... to strive for the release of the five nurses ...
... Basic Health Needs – a Report. A newspaper on Sunday ... 1999 in the nation's largest county jail system came after ... volume of inmates, coupled with a shortage of doctors and ... waiting to be examined. ,An investigation by the ...
... scientists have identified a cell population that is a ... frontotemporal dementia//, which is as common as Alzheimer's disease ... ,Because the cells arose only recently in evolutionary ... and humans-- and are particularly abundant in humans, and ...
... California, San Diego biologists have shown that the chemical ... //of electrical activity in the developing nervous system. The ... potential as a treatment for a wide range of ... in the early on-line edition of the journal Proceedings ...
Cached Medicine News:Health News:Link Between Nanoparticles and Kidney Stones 2Health News:Link Between Nanoparticles and Kidney Stones 3Health News:Health Care Suffers at Los Angeles Jails: Report 2Health News:Study Offers Window into Human Behavior, Brain Disease 2Health News:Study Offers Window into Human Behavior, Brain Disease 3Health News:Study Offers Window into Human Behavior, Brain Disease 4Health News:Electrical Activity Alters Language Used By Nerve Cells 2Health News:Electrical Activity Alters Language Used By Nerve Cells 3
(Date:1/14/2014)... , Jan. 14, 2014 HeartWare International, ... innovator of less invasive, miniaturized circulatory support technologies that ... announced that it expects revenues for the fourth quarter ... full-year 2013 revenues to approximately $208 million. ...
(Date:1/14/2014)... , Jan. 14, 2014 The Brandeis Medical Center, led ... a premier and affordable laser tattoo removal experience with ... Brandeis, focus is in providing high quality cosmetic services with cutting ... " Southern California has seen a ...
(Date:1/14/2014)... Jan. 14, 2014 Animal Emergency Critical Care, a LifeCentre partner ... Virginia is the first in Loudoun County ... Dr. Susan M. Barnes , Medical Director, is ... husband, Dr. Cole Taylor , are avid scuba divers. "As ...
Breaking Medicine Technology:HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Medicine Products: