Navigation Links
Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps
Date:11/22/2009

ins colleagues have long studied sinusitis, often growing sinus cells isolated from patients in petri dishes. After noticing that cells from patients with polyps typically multiplied faster than cells from normal patients, the researchers speculated that cells from polyp patients might be producing extra amounts of some type of growth factor, a protein that encourages cell growth.

To identify which growth factor might be to blame, the researchers had sinusitis patients with and without polyps rinse their sinus passages with a wash solution, then tested the runoff for the presence of various growth factors. They found that solution from patients with polyps contained high amounts of a substance called vascular endothelial growth factor, or VEGF, a protein important for normal blood vessel growth that also seems to play a key role in a variety of diseases, including cancer. The more VEGF they found in a cell culture, the faster those cells grew.

To further examine whether this protein is present not only in the sinus passages but also in the sinus tissue, Kim and her colleagues used a stain that highlights VEGF on sinus tissue removed from polyp-producing patients and those with other types of sinusitis. The stained tissue from polyp patients "lit up very dramatically, like a city skyline," Kim says, while the tissue from other patients showed little to no staining.

Though these results confirmed that the sinuses of patients with polyps were overproducing VEGF, the researchers still weren't sure that VEGF was instigating cell overgrowth seen in polyps. Looking for a cause-and-effect relationship, Kim and her team treated cells isolated from sinusitis patients with agents that inhibit VEGF production and action. The cells from polyp-producing patients slowed their growth rate to match that of normal patients.

"It's a strong indicator that VEGF is indeed responsible for the over-exuberant cell growth that contributes to polyp develo
'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. SC Johnson Makes Commitment to Clinton Global Initiative
2. CEL-SCI to Conduct First Clinical Study of Investigational LEAPS-H1N1 Treatment for Hospitalized H1N1 Infected Patients at Johns Hopkins University School of Medicine
3. EF Johnson Technologies, Inc. Announces Third Quarter Financial Reporting Date
4. Robert Wood Johnson Foundation, The Pew Charitable Trusts Launch National Initiative to Advance Policies That Promote Health
5. Johnson Matthey Expands San Diego Facility
6. Johnson & Johnson to Host Analyst Meeting to Discuss Third-Quarter Financial Results and Review Medical Devices & Diagnostics Business
7. Johns Hopkins epigenetic center receives $16.8 million NIH grant
8. SC Johnson a Best Company for Working Moms
9. SC Johnson Joins Conservation Internationals Team Earth, a Worldwide Sustainability Movement, As One of the Founding Members
10. EF Johnson Technologies, Inc. Receives Notice Regarding Minimum Bid Price Rule
11. Johnson & Johnson and Elan Corporation plc Announce Closing of Transaction Related to Alzheimers Immunotherapy Program and Equity Investment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Ticket Down is a reliable source ... at the Sun Life Stadium in early September. , Two ... Brazil and Colombia meet at Sun Life Stadium in Miami Gardens, ... in the world and will be a rematch of their thriller ... kick-off on Sept. 5 and will feature some of the best ...
(Date:8/20/2014)... August 20, 2014 The finalists are ... leading health-marketing industry trade magazine, will honor the pharmaceutical ... Awards are given to outstanding companies, marketers and brand ... , “We are proud to announce that we ... entries with double the number of submissions we received ...
(Date:8/20/2014)... 2014 Botanica Day Spa ... Utilizing the new and popular stem cell line ... lines and wrinkles and naturally repairs the skin. ... the new service by offering clients a complimentary ... cell facial. , Pevonia® continues to be a ...
(Date:8/20/2014)... Brain Tumour Research has been chosen by Plymouth University ... was launched in April 2009 to raise awareness of, ... improve outcomes for brain tumour patients. , A range ... raise funds for the charity, and members of staff ... be encouraged to donate, fundraise and volunteer. The involvement ...
(Date:8/20/2014)... If old age is a disease then this ... extensive research on HGH and stem cells technology, the L.A. ... the art of rubbing off decades from your face and ... their revolutionary anti-aging hormone therapy and regenerative medicine. , ... youth, the MD of MetroMD, Dr Alex Martin said this ...
Breaking Medicine News(10 mins):Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Match 2Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Match 3Health News:PM360 Announces 2014 Trailblazer Award Finalists 2Health News:PM360 Announces 2014 Trailblazer Award Finalists 3Health News:PM360 Announces 2014 Trailblazer Award Finalists 4Health News:PM360 Announces 2014 Trailblazer Award Finalists 5Health News:PM360 Announces 2014 Trailblazer Award Finalists 6Health News:PM360 Announces 2014 Trailblazer Award Finalists 7Health News:PM360 Announces 2014 Trailblazer Award Finalists 8Health News:New Stem Cell Facial Unveiled at Botanica Day Spa 2Health News:New Stem Cell Facial Unveiled at Botanica Day Spa 3Health News:Plymouth University chooses Brain Tumour Research as official charity 2Health News:MetroMD Offers Revolutionary Anti-aging Hormone Therapy in Hollywood Area 2
... Randy Dotinga HealthDay Reporter , TUESDAY, July 27 ... provide companionship: They also may boost your longevity, making as ... of studies suggests. Researchers combined the results of ... may live an average of almost 4 years longer than ...
... Reporter , TUESDAY, July 27 (HealthDay News) -- Infants born ... breathing problems compared with full-term babies, a new study finds. ... and 37th weeks of pregnancy -- account for about 9 ... researchers said. And too often, they are the result of ...
... Intimate partner violence results in 2 million injuries among ... Department of Health and Human Services. University of Missouri ... program that helps women experiencing abuse develop individualized safety ... Unlike current Internet resources, the decision-aid program ...
... Louisville, Ky. Smaller, rural hospitals may be quicker ... their larger, urban counterparts, and are capable of providing ... with major hospitals that provide a comprehensive array of ... led by researchers from the University of Louisville Department ...
... and who have abused their children can stop if they ... new study has found that mothers in families in which ... able to reduce how much they cursed at, yelled at, ... of home visits from therapists who taught them parenting skills. ...
... Ahmed H. Zewail, Ph.D., 1999 Chemistry Nobel Laureate and ... at the California Institute of Technology, has been named ... Chemical Society (ACS). The award recognizes Zewail,s revolutionary ... ultrafast processes in chemistry, biology and materials science. His ...
Cached Medicine News:Health News:Close Ties With Others Might Lengthen Life, Review Finds 2Health News:Delivering Babies Even a Few Weeks Early Ups Respiratory Risks 2Health News:Delivering Babies Even a Few Weeks Early Ups Respiratory Risks 3Health News:Use of decision-aid program increases safety for women experiencing abuse, researchers find 2Health News:Smaller hospitals can provide safe and high-quality surgical care comparable to larger counterparts 2Health News:Smaller hospitals can provide safe and high-quality surgical care comparable to larger counterparts 3Health News:Abusive mothers improve parenting after in-home training, emotional support of therapists 2Health News:Abusive mothers improve parenting after in-home training, emotional support of therapists 3Health News:American Chemical Society's highest honor goes to pioneer in 'ultraslow-motion' imaging 2Health News:American Chemical Society's highest honor goes to pioneer in 'ultraslow-motion' imaging 3
(Date:8/20/2014)... LOS ANGELES , Aug. 20, 2014   Easy Breathe ... today announced that its " Easy Blog " - has received ... the year.   "We are thrilled that so many ... Nick Weiss , CEO of Easy Breathe. "We,re committed to making ... use Easy Blog to stay informed about sleep apnea news ...
(Date:8/20/2014)... Reportlinker.com announces that a new market research report ... Patient Scales Industry http://www.reportlinker.com/p01374301/Global-Patient-Scales-Industry.html ... markets for Patient Scales in US$ Thousand by ... Baby Scales, Chair Scales, and Under Bed Scales. ... US, Canada, Japan, Europe, Asia-Pacific, Latin America, and ...
(Date:8/20/2014)... SAN MARCOS, Texas , Aug. 20, 2014 ... purchase of five diverse sets of patent families ... and major innovation driver for Bayer AG of ... The patents acquired provide broad intellectual property ... achieved in economical high-volume quantum dot (QD) manufacturing. ...
Breaking Medicine Technology:Easy Breathe Blog Emerges as the Go-To Resource for Sleep Apnea Sufferers 2Easy Breathe Blog Emerges as the Go-To Resource for Sleep Apnea Sufferers 3Easy Breathe Blog Emerges as the Go-To Resource for Sleep Apnea Sufferers 4Global Patient Scales Industry 2Global Patient Scales Industry 3Global Patient Scales Industry 4Global Patient Scales Industry 5Global Patient Scales Industry 6Global Patient Scales Industry 7Global Patient Scales Industry 8Global Patient Scales Industry 9Global Patient Scales Industry 10Global Patient Scales Industry 11Global Patient Scales Industry 12Global Patient Scales Industry 13Global Patient Scales Industry 14Global Patient Scales Industry 15Global Patient Scales Industry 16Global Patient Scales Industry 17Global Patient Scales Industry 18Global Patient Scales Industry 19Quantum Materials Acquires Bayer Technology Services Quantum Dot Manufacturing and Quantum Dot Solar Cell Patents 2Quantum Materials Acquires Bayer Technology Services Quantum Dot Manufacturing and Quantum Dot Solar Cell Patents 3Quantum Materials Acquires Bayer Technology Services Quantum Dot Manufacturing and Quantum Dot Solar Cell Patents 4
... Biopharma, Inc. CEO, John C. Rewcastle, Ph.D., will present ... April 25, 2012. The conference is being held at ... The IN3 Medical Device 360 Conference is hosted by ... networking meeting. The goal of the meeting is ,partnering ...
... April 25, 2012 Aethlon Medical, Inc. ... its Chairman and CEO, Jim Joyce. (Photo: ... originally formed to advance a medical device technology that ... the time, our strategy to treat infectious disease was ...
Cached Medicine Technology:Enox Biopharma, Inc. To Present Today At IN3 Medical Device 360 Conference In London 2Aethlon Medical Note: Marc Robins Joins the Aethlon Team 2
... Ergonomic Design for Unparalleled Comfort Pick ... Notice the balance. Notice the trigger and ejector ... Thats because our pipettors are ergonomically designed to ... hours of pipetting. Productivity In The Palm ...
... Design for Unparalleled Comfort Pick one of ... balance. Notice the trigger and ejector positionsright where ... our pipettors are ergonomically designed to help avoid ... pipetting. Productivity In The Palm Of Your ...
... The total ergonomic solution and best value ... feather touch action and ultra lightweight design ... tip ejection with long, lever tip ejector ... , Accepts universal tips or for greater ...
... Finnpipette BioControl multichannel has ... as the single channel ... fits all seven multichannel ... tip cone modules. Both ...
Medicine Products: