Navigation Links
Johns Hopkins researchers suppress 'hunger hormone'
Date:9/15/2008

Johns Hopkins scientists report success in significantly suppressing levels of the "hunger hormone" ghrelin in pigs using a minimally invasive means of chemically vaporizing the main vessel carrying blood to the top section, or fundus, of the stomach. An estimated 90 percent of the body's ghrelin originates in the fundus, which can't make the hormone without a good blood supply.

"With gastric artery chemical embolization, called GACE, there's no major surgery," says Aravind Arepally, M.D., clinical director of the Center for Bioengineering Innovation and Design and associate professor of radiology and surgery at the John Hopkins University School of Medicine. "In our study in pigs, this procedure produced an effect similar to bariatric surgery by suppressing ghrelin levels and subsequently lowering appetite."

Reporting on the research in the September 16 online edition of Radiology, Arepally and his team note that for more than a decade, efforts to safely and easily suppress grehlin have met with very limited success.

Bariatric surgery - involving the removal, reconstruction or bypass of part of the stomach or bowel - is effective in suppressing appetite and leading to significant weight loss, but carries substantial surgical risks and complications. "Obesity is the biggest biomedical problem in the country, and a minimally invasive alternative would make an enormous difference in choices and outcomes for obese people," Arepally says.

Arepally and colleagues conducted their study over the course of four weeks using 10 healthy, growing pigs; after an overnight fast, the animals were weighed and blood samples were taken to measure baseline ghrelin levels. Pigs were the best option, he says, because of their human-like anatomy and physiology.

Using X-ray for guidance, members of the research team threaded a thin tube up through a large blood vessel near the pigs' groins and then into the gastric arteries s
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Johnson & Johnson to Participate in Bear Stearns 20th Annual Healthcare Conference
2. Draxis Health selected by Johnson and Johnson Consumer Companies, Inc. for major contract manufacturing relationship
3. Johnson & Johnson Campaign for Nursings Future Joins With AACN to Offer New Minority Nurse Faculty Scholars Program
4. Johns Hopkins receives $100 million grant to speed research from clinic to community
5. Trust for Americas Health Receives $7.6 Million Grant from the Robert Wood Johnson Foundation to Advance the Quality and Impact of the Public Health System
6. Deane F. Johnson Center for Neurotherapeutics to Launch First Mobile Medical Unit on October 4th
7. Johnson & Johnson Tops Annual Pharmaceutical Company Rankings in a New Report From Industry-Leading Publication Scrip
8. Independence Technology, A Johnson & Johnson Company, Renews Its Contract With Creative Technology Services
9. In Johnstown Governor Rendell Launches Tour to Insure; Urges Passage of Plan to Give Access to Affordable Health Insurance
10. Johnson & Johnson Launches Global Diabetes Institute to Provide State-of-The- Art Education, Training to Health Professionals
11. Robert Wood Johnson Foundation Announces $15.6 Million Grant to Apply Power of the Archimedes Model to Critical Health Care Decisions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... When the mercury rises, heat can strain the limits ... takes on a heavier load in hot weather to keep ... the Harvard Men's Health Watch . , For otherwise ... knowing their limits and drinking enough fluids. But what about ... sensitive to the heat," says Dr. Joanne Foody, Director of ...
(Date:7/11/2014)... 11, 2014 Los Angeles dental ... he uses mini and full mouth implants to replace ... feature that distinguishes dental implants from other tooth replacements: ... the crowns. This alone prevents the long-term complications of ... advantages related to comfort, appearance and systemic health. Mini ...
(Date:7/11/2014)... A new study challenges the widely held belief that light ... Researchers analyzed more than 50 studies that examined drinking habits ... found that those with a form of a gene tied ... gene affects how a person,s body breaks down alcohol, resulting ... this variant has been shown to lead to lower drinking ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Cancer researchers ... have a significant impact on how patients respond to ... for mesothelioma. Surviving Mesothelioma has the full story. ... , Researchers at the University of Ljubljana and the ... pemetrexed for different types of polymorphisms. They found ...
(Date:7/11/2014)... 11, 2014 Anterior Cruciate Ligament (ACL) ... the type of material used to create a new ... game, say researchers presenting their work today at the ... Medicine ( AOSSM ). , “Our study ... (tissue harvested from a donor) fail more frequently than ...
Breaking Medicine News(10 mins):Health News:Take Common Sense Steps to Stay Safe This Summer, from the July 2014 Harvard Men's Health Watch 2Health News:Take Common Sense Steps to Stay Safe This Summer, from the July 2014 Harvard Men's Health Watch 3Health News:Dental Implant Dentist, Kevin Sands DDS, Now Uses Mini and Full Mouth Implants to Replace Missing Teeth 2Health News:A Little Alcohol May Not Be Good for Your Heart After All 2Health News:New Research Finds Genetic Variables Impact Chemotherapy Response, According to Surviving Mesothelioma 2Health News:ACL Reconstructions May Last Longer With Autografts 2
... disorders in this country has nearly doubled in the past ... psychologists and therapists are charged with the task, but many ... date and lack scientific rigor. This is in part because ... programs and for-profit training centersare not grounded in science. ...
... today for excellence in research, advancing oral health ... receive the 2009 American Dental Association,s (ADA) Gold Medal Award ... presentation during a meeting of the ADA,s House of ... every three years, the award honors individuals who contribute to ...
... Beginning October 1st, The Peninsula Chicago will dedicate itself to ... several cancer research and education organizations. , "We all know ... some way and this is why we at The Peninsula ... manager of The Peninsula Chicago. "In addition to the initiatives ...
... the largest non-government, not-for-profit funding source of cancer research ... research and training grants totaling $45,097,000 to 61 institutions ... 2009. The grants go into effect beginning January 1, ... Cancer Society has funded research and training of health ...
... ... Medical Center,s Emergency Department will begin using a new procedure, called therapeutic hypothermia, to ... , ... 2009 -- On October 19, 2009, Baptist Medical Center,s Emergency Department will ...
... Organization Exclusively for LTC Consumers Receives ... (formerly the National Citizens, Coalition for Nursing Home Reform) announced ... will help strengthen the organization,s role as a voice for ... organization exclusively for residents and their families and is a ...
Cached Medicine News:Health News:Where's the science? The sorry state of psychotherapy 2Health News:ADA's 2009 Gold Medal Award Presentation Set for 150th Annual Session 2Health News:The Peninsula Chicago Gives Back During Breast Cancer Awareness Month 2Health News:American Cancer Society awards 94 new research and training grants at 61 institutions nationwide 2Health News:American Cancer Society awards 94 new research and training grants at 61 institutions nationwide 3Health News:American Cancer Society awards 94 new research and training grants at 61 institutions nationwide 4Health News:American Cancer Society awards 94 new research and training grants at 61 institutions nationwide 5Health News:Baptist Using Therapeutic Hypothermia to Save Heart Attack Patients 2Health News:Long-Term Care Consumer Voices Strengthened 2
(Date:7/10/2014)... , July 10, 2014  Valeant Pharmaceuticals International, Inc. ... announced it has completed the sale to Galderma of ... owned or held by Valeant for $1.4 billion in ... S.A, which recently completed its acquisition of Galderma. ... of our products to a company that is firmly ...
(Date:7/10/2014)... CVS Caremark Corporation (NYSE: CVS ) ... quarterly dividend of $0.275 (27.5 cents) per share on the ... 2014, to holders of record on July 21, 2014. ... dedicated to helping people on their path to better health ... United States . Through the company,s more than 7,600 ...
(Date:1/15/2014)... , Jan. 15, 2014 Most osteoporosis patients want ... a recent online survey* sponsored by Mission Pharmacal Company. ... National Osteoporosis Foundation online support community, revealed that 74 ... that comes in a form other than a pill ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3
... Addressing the key clinical and economic issues ... System is designed to maximize tension control ... The system combines efficient instrumentation with a ... Grip system is indicated for general orthopaedic ...
... In 1985, the worlds first ... by Howmedica Osteonics as a means ... wire for trochanteric reattachment procedures. Today, ... papers demonstrating clinical successes, the Dall-Miles™ ...
The Assistant Free Self-Retaining Hip Surgery Retractor System is used for hip arthroplasty and hip fracture surgery....
... have become the accepted standard for,excellence and ... AML Total Hip System was the first ... meet the needs for biological fixation in ... 15 years of documented clinical performance, the ...
Medicine Products: