Navigation Links
Johns Hopkins researchers suppress 'hunger hormone'
Date:9/15/2008

Johns Hopkins scientists report success in significantly suppressing levels of the "hunger hormone" ghrelin in pigs using a minimally invasive means of chemically vaporizing the main vessel carrying blood to the top section, or fundus, of the stomach. An estimated 90 percent of the body's ghrelin originates in the fundus, which can't make the hormone without a good blood supply.

"With gastric artery chemical embolization, called GACE, there's no major surgery," says Aravind Arepally, M.D., clinical director of the Center for Bioengineering Innovation and Design and associate professor of radiology and surgery at the John Hopkins University School of Medicine. "In our study in pigs, this procedure produced an effect similar to bariatric surgery by suppressing ghrelin levels and subsequently lowering appetite."

Reporting on the research in the September 16 online edition of Radiology, Arepally and his team note that for more than a decade, efforts to safely and easily suppress grehlin have met with very limited success.

Bariatric surgery - involving the removal, reconstruction or bypass of part of the stomach or bowel - is effective in suppressing appetite and leading to significant weight loss, but carries substantial surgical risks and complications. "Obesity is the biggest biomedical problem in the country, and a minimally invasive alternative would make an enormous difference in choices and outcomes for obese people," Arepally says.

Arepally and colleagues conducted their study over the course of four weeks using 10 healthy, growing pigs; after an overnight fast, the animals were weighed and blood samples were taken to measure baseline ghrelin levels. Pigs were the best option, he says, because of their human-like anatomy and physiology.

Using X-ray for guidance, members of the research team threaded a thin tube up through a large blood vessel near the pigs' groins and then into the gastric arteries supplying blood to the stomachs. There, they administered one-time injections of saline in the left gastric arteries of five control pigs, and in the other five, one-time injections of sodium morrhuate, a chemical that destroys the blood vessels.

The team then sampled the pigs' blood for one month to monitor ghrelin values. The levels of the hormone in GACE-treated pigs were suppressed up to 60 percent from baseline.

"Appetite is complicated because it involves both the mind and body," Arepally says. "Ghrelin fluctuates throughout the day, responding to all kinds of emotional and physiological scenarios. But even if the brain says "produce more ghrelin," GACE physically prevents the stomach from making the hunger hormone."


'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. Johnson & Johnson to Participate in Bear Stearns 20th Annual Healthcare Conference
2. Draxis Health selected by Johnson and Johnson Consumer Companies, Inc. for major contract manufacturing relationship
3. Johnson & Johnson Campaign for Nursings Future Joins With AACN to Offer New Minority Nurse Faculty Scholars Program
4. Johns Hopkins receives $100 million grant to speed research from clinic to community
5. Trust for Americas Health Receives $7.6 Million Grant from the Robert Wood Johnson Foundation to Advance the Quality and Impact of the Public Health System
6. Deane F. Johnson Center for Neurotherapeutics to Launch First Mobile Medical Unit on October 4th
7. Johnson & Johnson Tops Annual Pharmaceutical Company Rankings in a New Report From Industry-Leading Publication Scrip
8. Independence Technology, A Johnson & Johnson Company, Renews Its Contract With Creative Technology Services
9. In Johnstown Governor Rendell Launches Tour to Insure; Urges Passage of Plan to Give Access to Affordable Health Insurance
10. Johnson & Johnson Launches Global Diabetes Institute to Provide State-of-The- Art Education, Training to Health Professionals
11. Robert Wood Johnson Foundation Announces $15.6 Million Grant to Apply Power of the Archimedes Model to Critical Health Care Decisions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... Conshohocken, PA (PRWEB) , ... March 27, 2017 ... ... in business simulation -centric training, today announced the launch of a new ... corporate strategy, having the skills needed to execute that strategy, and the actual ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... nurses and supply chain professionals, will hold their first Northeast Regional AHVAP Meeting. ... Bundles.” , “Increasingly, supply chain and value analysis professionals have a ‘seat ...
(Date:3/27/2017)... California (PRWEB) , ... March 27, 2017 , ... The ... to its customers. First National Capital has added 10 new sales professionals over the ... its sales positions by 15 additional new hires over the course of 2017. ...
(Date:3/27/2017)... , ... March 27, 2017 , ... ... a settlement agreement to resolve the pending litigation between itself and 1800 Vending ... District of Utah). , “I am thrilled to announce that we have now ...
(Date:3/27/2017)... ... March 27, 2017 , ... The homeowner improvement and repair market is ... DIY and unlicensed contractors for renovations is also on the rise. Per a 2017 ... and of those, 42% failed to use a licensed contractor.(2) The risks associated with ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... 2017 FinancialBuzz.com News Commentary  ... According to a new report by Arcview Market Research, ... grew 34 percent to $6.7 billion and can be expected to grow ... next five years, from $6.7 billion in 2016, to $22.6 billion in ... able to purchase cannabis without a doctor,s recommendation. Voters in ...
(Date:3/27/2017)... 27, 2017 /PRNewswire/ - INVICTUS MD STRATEGIES CORP. ("Invictus ... Invictus MD is pleased to announce it has received ... on the TSX Venture Exchange.  Receiving ... year of significant achievements for Invictus-MD. Some of which ... at AB Laboratories Inc. ("AB Labs"), a Licensed Producer ...
(Date:3/27/2017)... The staggering cost of cancer treatment means ... to the latest treatment options against cancer. Even among ... have inadequate or no health insurance and are oftentimes ... to modern cancer treatment is almost non-existent for cancer ... The mission statements of pharmaceutical and biotech companies often ...
Breaking Medicine Technology: