Navigation Links
Johns Hopkins researchers suppress 'hunger hormone'
Date:9/15/2008

Johns Hopkins scientists report success in significantly suppressing levels of the "hunger hormone" ghrelin in pigs using a minimally invasive means of chemically vaporizing the main vessel carrying blood to the top section, or fundus, of the stomach. An estimated 90 percent of the body's ghrelin originates in the fundus, which can't make the hormone without a good blood supply.

"With gastric artery chemical embolization, called GACE, there's no major surgery," says Aravind Arepally, M.D., clinical director of the Center for Bioengineering Innovation and Design and associate professor of radiology and surgery at the John Hopkins University School of Medicine. "In our study in pigs, this procedure produced an effect similar to bariatric surgery by suppressing ghrelin levels and subsequently lowering appetite."

Reporting on the research in the September 16 online edition of Radiology, Arepally and his team note that for more than a decade, efforts to safely and easily suppress grehlin have met with very limited success.

Bariatric surgery - involving the removal, reconstruction or bypass of part of the stomach or bowel - is effective in suppressing appetite and leading to significant weight loss, but carries substantial surgical risks and complications. "Obesity is the biggest biomedical problem in the country, and a minimally invasive alternative would make an enormous difference in choices and outcomes for obese people," Arepally says.

Arepally and colleagues conducted their study over the course of four weeks using 10 healthy, growing pigs; after an overnight fast, the animals were weighed and blood samples were taken to measure baseline ghrelin levels. Pigs were the best option, he says, because of their human-like anatomy and physiology.

Using X-ray for guidance, members of the research team threaded a thin tube up through a large blood vessel near the pigs' groins and then into the gastric arteries s
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Johnson & Johnson to Participate in Bear Stearns 20th Annual Healthcare Conference
2. Draxis Health selected by Johnson and Johnson Consumer Companies, Inc. for major contract manufacturing relationship
3. Johnson & Johnson Campaign for Nursings Future Joins With AACN to Offer New Minority Nurse Faculty Scholars Program
4. Johns Hopkins receives $100 million grant to speed research from clinic to community
5. Trust for Americas Health Receives $7.6 Million Grant from the Robert Wood Johnson Foundation to Advance the Quality and Impact of the Public Health System
6. Deane F. Johnson Center for Neurotherapeutics to Launch First Mobile Medical Unit on October 4th
7. Johnson & Johnson Tops Annual Pharmaceutical Company Rankings in a New Report From Industry-Leading Publication Scrip
8. Independence Technology, A Johnson & Johnson Company, Renews Its Contract With Creative Technology Services
9. In Johnstown Governor Rendell Launches Tour to Insure; Urges Passage of Plan to Give Access to Affordable Health Insurance
10. Johnson & Johnson Launches Global Diabetes Institute to Provide State-of-The- Art Education, Training to Health Professionals
11. Robert Wood Johnson Foundation Announces $15.6 Million Grant to Apply Power of the Archimedes Model to Critical Health Care Decisions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... (PRWEB) December 26, 2014 Parker ... for the best in heating, cooling and plumbing ... 24 hour emergency services in 2014 with regard ... know that Arizona is known for its incredibly ... that understands the intricacies and details of a ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 ... BambooFlooringChina.com combines beauty, strength and durability. Today, the ... promotion, which is valid until Jan. 30, 2015. ... grain of traditional hardwood. BambooFlooringChina.com is a well-known ... help consumers worldwide to find a reliable bamboo ...
(Date:12/25/2014)... Product liability lawsuits filed in the ... http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal court, ... in the U.S. District Court, Northern District of Ohio ... conference on January 7, 2015, at the Paul G. ... Palm Beach, Florida. The Conference is scheduled to begin ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 Recently, Dylan ... dresses, has excitedly released its collection of discounted prom ... to Percy, a senior spokesman of the company, the ... of this promotion is to expand the UK market. ... in several different colors, lengths, and styles: A-line strapless, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... , ... ... , ... , , ...
... help infants with prenatal complications or who were injured ... University of Michigan researcher. Prenatal injuries can often ... toddlers get a more serious diagnosis, such as cerebral ... at the U-M School of Kinesiology. Some of those ...
... on more pounds than recommended are most susceptible, researchers ... Excessive weight gain during pregnancy, especially the first trimester, ... U.S. researchers. , Their three-year study included 345 pregnant ... gestational diabetes, which is defined as glucose intolerance that ...
... pharmacists, respiratory therapists and an ,intensivist, increases the odds ... News) -- Intensive care patients are less likely to ... care team that includes doctors, nurses, respiratory therapists, clinical ... Researchers analyzed data from more than 107,000 patients admitted ...
... in which females cannot fly may help curb the transmission ... Dengue fever causes severe flulike symptoms and is among ... million to 100 million cases per year, and nearly 40 ... virus is spread through the bite of infected female ...
... ... ... , ... , , , , ...
Cached Medicine News:Health News:AT&T Foundation's $50,000 Donation to National Health Foundation Supports Teen Pregnancy Prevention Program 2Health News:AT&T Foundation's $50,000 Donation to National Health Foundation Supports Teen Pregnancy Prevention Program 3Health News:Treadmill training could help tots walk 2Health News:Excessive Weight Gain During Pregnancy Raises Gestational Diabetes Risk 2Health News:ICU Patients Gain From Team Approach to Care 2Health News:Flightless mosquitoes developed to help control dengue fever 2Health News:Partners Home Care Scores in Top Tier in National Medicare Demonstration Project 2Health News:Partners Home Care Scores in Top Tier in National Medicare Demonstration Project 3Health News:Partners Home Care Scores in Top Tier in National Medicare Demonstration Project 4
(Date:12/24/2014)... , Dec. 24, 2014  Actavis plc ... the Company has received a complete response letter ... for its New Drug Application (NDA) for the ... the treatment of hypertension.   Photo - ... are disappointed in the receipt of a complete ...
(Date:12/24/2014)... 24, 2014 Kinex Pharmaceuticals announced today that ... Roswell Park Cancer Institute. KX2-361 (KX02), a ... has shown potent inhibitory activity against a broad panel ... resistant to Temozolomide (T98G), the most widely used chemotherapy ... brain tumor mouse model, KX2-361 consistently clears brain tumors ...
(Date:12/24/2014)... 2014  Conkwest, Inc., the Natural Killer Cell ... Killer (NK) cell-line platform, Neukoplast® (NK-92™) as an ... , NantWorks founder, physician scientist and biotechnology entrepreneur, ... approximately $48 million of the Company,s Class A ... will be named Co-Chairman of the Conkwest Board ...
Breaking Medicine Technology:Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 2Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 3Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 4Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 2Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 4Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 5
... Label Gallery is a unique ... software based on an easy-to-use and ... SATO Printers. Label Gallery offers a ... including a multi-lingual user interface and ...
... Hugs tag is a small radio ... an unobtrusive ergonomic design. The tag ... enabled as soon as the tag ... tag emits an electronic Heartbeat® signal ...
... is a patent pending solution using ... in a smart label to promote ... wrong-patient, wrong-site, wrong-procedure surgery. This simple ... an orthopedic surgeon with the operating ...
PDC Smart® Wrist Tag provides read/write and data storage capabilities....
Medicine Products: