Navigation Links
Johns Hopkins researchers return blood cells to stem cell state
Date:8/22/2012

genes to cells to turn on processes that convert the cells from one type (such as skin or blood) back to stem cell states. However, viruses used in this way can mutate genes and initiate cancers in newly transformed cells. To insert the genes without using a virus, Zambidis' team uses plasmids, rings of DNA that replicate briefly inside cells and then degrade. The blood cells were also given an additional new step in which they were stimulated with their natural bone-marrow environment.

For the new study, the Johns Hopkins team took cord blood cells, treated them with growth factors, and used plasmids to transfer four genes into them. They then delivered an electrical pulse to the cells, making tiny holes in the surface through which the plasmids could slip inside. Once inside, the plasmids triggered the cells to revert to a more primitive cell state. The scientific team next grew some of the treated cells in a dish alone, and some together with irradiated bone-marrow cells.

When scientists compared the cells grown using the blood cell method with iPS cells grown from hair cells and from skin cells, they found that the most superior iPS cells came from blood stem cells treated with just four genes and cultured with the bone marrow cells. These cells converted to a primitive stem cell state within seven to 14 days. Their techniques also were successful in experiments with blood cells from adult bone marrow and from circulating blood.

In ongoing studies, Zambidis and colleagues are testing the quality of the newly formed iPS cells and their ability to convert to other cell types, as compared with iPS cells made by other methods.

Efficient methods to produce virus-free iPS cells may speed research to develop stem cell therapies, using nearly all cell types, and may provide a more accurate picture of cell development and biology.


'/>"/>
Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Johnson & Johnson Violated FDA Order to Halt Sales of Transvaginal Mesh
2. Johns Hopkins African bioethics program receives 5-year continuation grant from NIH
3. 29 Johns Hopkins stem cell researchers awarded funding
4. Researchers highlight treatment, research needs for homeless families
5. Catalan researchers identify a key component of cell division
6. Spirituality correlates to better mental health regardless of religion, say MU researchers
7. IU researchers interview pro-anorexic bloggers for groundbreaking new study
8. Researchers awarded National Cancer Institute grants aimed at answering provocative questions
9. Why are elderly duped? UI researchers explain why
10. Moffitt Cancer Center researchers validate molecular signature to predict radiation therapy benefit
11. By studying animal health, researchers find improved ways for developing, testing cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 20, 2014 It’s hard to imagine what ... and vulnerable children around the world, it’s a reality. And ... many children are forced to walk barefoot on rocky terrain ... or play with their friends. , Buckner International's ... Air1 Radio in October to encourage support for Air1 ...
(Date:10/19/2014)... Hastings and Hastings, a Phoenix personal injury ... the greater Phoenix area and across Arizona reports record ... catastrophic automobile accidents. Statistics have indicated a steady increase ... As such, Hastings and Hastings has seen a steady ... who have been injured through no fault of their ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 This ... for Partial Seizure, complete with comparative analysis at ... of action (MoA), route of administration (RoA) and ... news and press releases. It also reviews key ... Seizure and special features on late-stage and discontinued ...
(Date:10/19/2014)... SweetDressy.com, a professional company of women’s ... for long evening dresses . All the company’s ... the current discount is up to 66 percent off. ... in the fashion field. Its dress specialists are striving ... various parts of the world. All the company’s items ...
(Date:10/19/2014)... is a systemic disease that causes inflammation in ... affected members of the ancient Egyptian royal families. ... & Rheumatology , a journal of the American ... instead a degenerative spinal condition called diffuse idiopathic ... the 18th to early 20th Dynasties. , ...
Breaking Medicine News(10 mins):Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 2Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 3Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 4Health News:Promotion For Beautiful Long Evening Dresses Launched By SweetDressy.com 2Health News:Mummy remains refute antiquity of ankylosing spondylitis 2
... ... availability of its new Alterian Content Manager, Professional Edition. This product ... collaboration with Microsoft, together into one package for partners and customers ... Content Manager is the Content Management System (CMS) behind more than ...
... ... selection of deals for Mother’s Day. Experienced experts research the internet to provide the ... as laptops, HDTVs, Father’s Day and graduation. , ... (PRWEB) April 26, 2010 -- Mother’s Day Deals ...
... ... is extremely difficult to identify what level of degradation has taken place caused by factors ... used racking must recognise that any uncertainty presents serious safety risks that they can be ... ...
... ... business Internet video advertising program that can deliver first page Internet search ... web page search engine optimization. The Site Steering small business advertising program ... using a proprietary method to distribute the video to the Internet. ...
... Using routine data from electronic patient records to select individuals ... all adults aged between 40 and 74 years of age, ... cheaper to run, according to research published on bmj.com ... in the last twenty years, heart problems remain the leading ...
... ... $150,000 Contribution to Assist the Haitian People, , ... Palm Beach, FL (Vocus) April 25, 2010 -- The ... and improves public policy by communicating pharmacy and suppliers’ work to improve lives and ...
Cached Medicine News:Health News:Alterian Releases Professional Edition of its Content Manager Technology, Offering Partners and Clients an Even Faster Time-to-Live for Their Websites 2Health News:Alterian Releases Professional Edition of its Content Manager Technology, Offering Partners and Clients an Even Faster Time-to-Live for Their Websites 3Health News:Alterian Releases Professional Edition of its Content Manager Technology, Offering Partners and Clients an Even Faster Time-to-Live for Their Websites 4Health News:Expert Approved: FatWallet Guides Mother's Day Shoppers to the Best Deals Online 2Health News:Warning Over Dangers of Used Racking Issued By Thistle Systems 2Health News:Warning Over Dangers of Used Racking Issued By Thistle Systems 3Health News:Site Steering Launches Keyword Targeted Small Business Internet Video Advertising Program That Achieves First Page Search Results Within Days 2Health News:Site Steering Launches Keyword Targeted Small Business Internet Video Advertising Program That Achieves First Page Search Results Within Days 3Health News:Selecting high-risk patients for heart screening 2Health News:NACDS' Anderson Says Retailers and Suppliers' “Health and Wellness Renaissance” is Creating a “Historic, Watershed Moment” 2Health News:NACDS' Anderson Says Retailers and Suppliers' “Health and Wellness Renaissance” is Creating a “Historic, Watershed Moment” 3Health News:NACDS' Anderson Says Retailers and Suppliers' “Health and Wellness Renaissance” is Creating a “Historic, Watershed Moment” 4
(Date:10/17/2014)... 17, 2014  Training market researchers to spot ... factor in today,s highly competitive global marketplace. As ... that effectively and efficiently produce high performing analysts, ... Effective training programs can help ... from internal clients by developing analysts who can ...
(Date:10/17/2014)... UBM Medica US announces that Neurology Times ... for neurologists and other healthcare providers, features special coverage on ... discussions of the latest developments in approaches to diagnosis. ... , more than the total of those who have multiple ... can be difficult because there are no confirmatory medical tests. ...
(Date:10/17/2014)... According to the ... (Optical Coherence Tomography, Hyperspectral Imaging, Photoacoustic Tomography), Product ... Oncology, Cardiology) - Global Forecasts to 2019" ... Imaging market over the forecast period of ... million in 2014 and is expected to ...
Breaking Medicine Technology:Effective Training Programs for Market Research Groups can Boost Overall Organizational Success 2Neurology Times Features Coverage of Parkinson and Alzheimer Disease 2Neurology Times Features Coverage of Parkinson and Alzheimer Disease 3Optical Imaging Market Worth $1,669.2 Million by 2019 2Optical Imaging Market Worth $1,669.2 Million by 2019 3Optical Imaging Market Worth $1,669.2 Million by 2019 4
... Wound Management division of Smith & Nephew (LSE: SN; NYSE: ... on a range of products and therapies from their ALLEVYN ... wound care portfolio. The data demonstrate advanced healing strategies and ... Results of the studies are being presented at the Clinical ...
... 2011 Cardica, Inc. (Nasdaq: CRDC ... System will be featured in a clinical presentation ... Carolina Heart Institute-International Society for Minimally Invasive Cardiothoracic ... presentation, entitled "Robotic Coronary Revascularization: Connectors and Pearls," ...
Cached Medicine Technology:Smith & Nephew Showcases Strong Data at the Clinical Symposium on Advances in Skin & Wound Care Conference 2Smith & Nephew Showcases Strong Data at the Clinical Symposium on Advances in Skin & Wound Care Conference 3Smith & Nephew Showcases Strong Data at the Clinical Symposium on Advances in Skin & Wound Care Conference 4Cardica's Cardiac Anastomosis Device Featured in Clinical Presentation on Robotic Cardiac Bypass Procedures 2Cardica's Cardiac Anastomosis Device Featured in Clinical Presentation on Robotic Cardiac Bypass Procedures 3
The CGIL iridectomy contact glass was designed by Riquin, Fankhauser et al. to perform full thickness peripheral laser iridectomies....
The CGVL vitrectomy contact glass was designed by Rol, Fankhauser et al. for photodisruptive YAG laser procedures in the posterior vitreous....
For newly born children 10 mm internal diameter of the cornea part. Designed to work with argon/YAG Lasers....
... uses a classical distance-independent measuring principle which ... The size of the mire image is ... and the measured object; 2. The resulting ... the Ophthalmometer and the measured object; 3. ...
Medicine Products: