Navigation Links
Johns Hopkins researchers discover new schizophrenia gene
Date:2/3/2009

Researchers at the Johns Hopkins University School of Medicine are one gene closer to understanding schizophrenia and related disorders. Reporting in the Jan. 9 issue of the American Journal of Human Genetics, the team describes how a variation in the neuregulin 3 gene influences delusions associated with schizophrenia.

"Neuregulin 3 is clearly one more gene to add to the few currently known to contribute to schizophrenia," says David Valle, M.D., director of the McKusick-Nathans Institute of Genetic Medicine at Hopkins. "There's much more to do, but we're making progress."

Schizophrenia is a varied condition with a number of symptoms not shared by all affected. This could be one reason why it's been difficult to identify genes that contribute to the condition.

To address this, the team first rigorously separated the 73 different symptoms into nine distinct factors associated with the conditionprodromal, negative, delusion, affective, scholastic, adolescent sociability, disorganization, disability, hallucination.

Then, using genetic samples from more than 450 people with schizophrenia and their parents as well as unrelated non-affected people for comparison, the team focused on one region of chromosome 10 that previously had been implicated to contain genes that contribute to the condition. They analyzed more than 1,400 single nucleotide polymorphisms, or SNPs for short, to see if any particular SNPs were more frequently carried by schizophrenia patients than unaffected people.

They found three SNPs strongly associated with delusions, and all three SNPs are located in the neuregulin 3 gene. In fact, of the team's top 20 most significant SNPs, 13 of them are located at or near this gene, but rather than being associated with delusion, the other SNPs are associated with scholastic, disorganization and hallucination factors.

"Neuregulin 3 makes sense because it's turned on mostly in the central nervous system, and the related gene neuregulin 1 also has been shown to be associated with schizophrenia," says Dimitrios Avramopoulos, M.D., Ph.D., an associate professor of psychiatry and member of the Institute of Genetic Medicine.

"We're still at the stage of trying to understand the disease, figuring out what goes wrong in the brain," says Avramopoulos who adds that the next step for this team is to follow up and sequence the neuregulin 3 gene from a number of the patients in this study to look for rare genetic variants that might also contribute to the condition.


'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. Johnson & Johnson to Participate in Bear Stearns 20th Annual Healthcare Conference
2. Draxis Health selected by Johnson and Johnson Consumer Companies, Inc. for major contract manufacturing relationship
3. Johnson & Johnson Campaign for Nursings Future Joins With AACN to Offer New Minority Nurse Faculty Scholars Program
4. Johns Hopkins receives $100 million grant to speed research from clinic to community
5. Trust for Americas Health Receives $7.6 Million Grant from the Robert Wood Johnson Foundation to Advance the Quality and Impact of the Public Health System
6. Deane F. Johnson Center for Neurotherapeutics to Launch First Mobile Medical Unit on October 4th
7. Johnson & Johnson Tops Annual Pharmaceutical Company Rankings in a New Report From Industry-Leading Publication Scrip
8. Independence Technology, A Johnson & Johnson Company, Renews Its Contract With Creative Technology Services
9. In Johnstown Governor Rendell Launches Tour to Insure; Urges Passage of Plan to Give Access to Affordable Health Insurance
10. Johnson & Johnson Launches Global Diabetes Institute to Provide State-of-The- Art Education, Training to Health Professionals
11. Robert Wood Johnson Foundation Announces $15.6 Million Grant to Apply Power of the Archimedes Model to Critical Health Care Decisions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... 2017 , ... Catalent Pharma Solutions, the leading global provider ... products, today announced that Mr. Michael Merges, Director of Strategic Growth, Catalent Biologics ... at the Mayflower Hotel, Washington DC, on Jan. 24 – 26, 2017. , ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... the first time support an aid project with the donation of cochlear implants. ... the gift of hearing and thus a fair chance of leading an independent ...
(Date:1/18/2017)... CA (PRWEB) , ... January 18, 2017 , ... ... dental problems ranging from gum disease to enamel erosion, and those dental problems ... Massachusetts Department of Public Health, many pregnant women are failing to get the ...
(Date:1/17/2017)... ... January 17, 2017 , ... January is National Stalking Awareness Month (NSAM), ... lurk in the corners and commit the crime of stalking, a very real danger to ... an often overlooked factor in stalking and other crimes. , “Stalking: know it. Name it. ...
(Date:1/17/2017)... ... 2017 , ... Gym Source, America’s leading retailer of premium residential and commercial ... in Miami, FL. , “We are elated to be opening this new showroom,” explains ... designed to give clients a seamless and motivating shopping experience.” , Every fitness journey ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... HARRISBURG, Pa. , Jan. 17, 2017 ... Drug and Alcohol Programs Secretary Gary Tennis ... with carfentanil, following two recent overdose deaths from the ... "Carfentanil is intended to sedate large animals ... potentially kill anyone who comes into contact with it," ...
(Date:1/17/2017)... EU5 Glucose Monitoring Market Outlook to 2022 ... Monitoring Market Outlook to 2022", provides key market data ... value, in millions of US dollars, volume (in units) ... Glucose Meters, Blood Glucose Test Strips and Lancets. ... data for each of these market segements, and global ...
(Date:1/17/2017)... 2017 The interventional radiology products market is ... USD 6.35 billion in 2016, at a CAGR of ... this market are rising incidence of chronic diseases, rising ... The global interventional radiology products market is ... the basis of type, the stents segment is expected ...
Breaking Medicine Technology: