Navigation Links
Johns Hopkins researchers discover new schizophrenia gene
Date:2/3/2009

Researchers at the Johns Hopkins University School of Medicine are one gene closer to understanding schizophrenia and related disorders. Reporting in the Jan. 9 issue of the American Journal of Human Genetics, the team describes how a variation in the neuregulin 3 gene influences delusions associated with schizophrenia.

"Neuregulin 3 is clearly one more gene to add to the few currently known to contribute to schizophrenia," says David Valle, M.D., director of the McKusick-Nathans Institute of Genetic Medicine at Hopkins. "There's much more to do, but we're making progress."

Schizophrenia is a varied condition with a number of symptoms not shared by all affected. This could be one reason why it's been difficult to identify genes that contribute to the condition.

To address this, the team first rigorously separated the 73 different symptoms into nine distinct factors associated with the conditionprodromal, negative, delusion, affective, scholastic, adolescent sociability, disorganization, disability, hallucination.

Then, using genetic samples from more than 450 people with schizophrenia and their parents as well as unrelated non-affected people for comparison, the team focused on one region of chromosome 10 that previously had been implicated to contain genes that contribute to the condition. They analyzed more than 1,400 single nucleotide polymorphisms, or SNPs for short, to see if any particular SNPs were more frequently carried by schizophrenia patients than unaffected people.

They found three SNPs strongly associated with delusions, and all three SNPs are located in the neuregulin 3 gene. In fact, of the team's top 20 most significant SNPs, 13 of them are located at or near this gene, but rather than being associated with delusion, the other SNPs are associated with scholastic, disorganization and hallucination factors.

"Neuregulin 3 makes sense because it's turned on mostly in the central nervous
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Johnson & Johnson to Participate in Bear Stearns 20th Annual Healthcare Conference
2. Draxis Health selected by Johnson and Johnson Consumer Companies, Inc. for major contract manufacturing relationship
3. Johnson & Johnson Campaign for Nursings Future Joins With AACN to Offer New Minority Nurse Faculty Scholars Program
4. Johns Hopkins receives $100 million grant to speed research from clinic to community
5. Trust for Americas Health Receives $7.6 Million Grant from the Robert Wood Johnson Foundation to Advance the Quality and Impact of the Public Health System
6. Deane F. Johnson Center for Neurotherapeutics to Launch First Mobile Medical Unit on October 4th
7. Johnson & Johnson Tops Annual Pharmaceutical Company Rankings in a New Report From Industry-Leading Publication Scrip
8. Independence Technology, A Johnson & Johnson Company, Renews Its Contract With Creative Technology Services
9. In Johnstown Governor Rendell Launches Tour to Insure; Urges Passage of Plan to Give Access to Affordable Health Insurance
10. Johnson & Johnson Launches Global Diabetes Institute to Provide State-of-The- Art Education, Training to Health Professionals
11. Robert Wood Johnson Foundation Announces $15.6 Million Grant to Apply Power of the Archimedes Model to Critical Health Care Decisions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... (PRWEB) July 31, 2014 1Heart ... year round to CEO Belina Calderon’s group of ... and medical billing, 1Heart Caregiver Services, L.A. Jobs ... Academy applauds the most recent resource speaker and ... Glenn Bowie for sharing his expertise and knowledge ...
(Date:7/31/2014)... 2014 “Bivalent, Heteronomy and Natural Killer ... hottest metal bands ~ homeostatic CS science is the ... July Roundup, new on the Bryan William Brickner ... and the cannabinoid system (CS). The line-up links to ... wellness: three directly on homeostasis, two each on the ...
(Date:7/31/2014)... National non-profit World T.E.A.M. Sports’ annual Adventure ... 12-14, following two years in the high Colorado Plateau. ... and able-bodied athletes competing together in an inclusive outdoor ... experienced adventure athletes. , Hosted at the rustic ... River in the rugged Gore Mountains northwest of Vail, ...
(Date:7/31/2014)... In its latest blog post, Best ... having family close by during a stay in rehab can ... is successful, is looking at 10 tips to help drug ... recovery is a lifelong process, and one that former addicts ... without compromise,” commented Best Drug Rehabilitation’s CEO Per Wickstrom ...
(Date:7/31/2014)... Upper Marlboro, MD (PRWEB) July 31, 2014 ... names in hair care, from Clairol to Shea Moisture. And ... roster: G’ Natural Herbal Products. Starting August 1, guests will ... , Founded in 1996 with $200 investment, CEO Roger Gore ... that his own hair was thinning and developing a receding ...
Breaking Medicine News(10 mins):Health News:1Heart Business Academy Applauds Resource Speaker and Trainer Los Angeles Area Chamber of Commerce Ambassador Glenn Bowie 2Health News:1Heart Business Academy Applauds Resource Speaker and Trainer Los Angeles Area Chamber of Commerce Ambassador Glenn Bowie 3Health News:1Heart Business Academy Applauds Resource Speaker and Trainer Los Angeles Area Chamber of Commerce Ambassador Glenn Bowie 4Health News:Homeostatic Cannabinoid Science ~ Publius’ July Roundup on the Bryan William Brickner Blog 2Health News:World T.E.A.M. Sports’ Adventure Team Challenge Returns to Colorado’s High Country 2Health News:World T.E.A.M. Sports’ Adventure Team Challenge Returns to Colorado’s High Country 3Health News:New Best Drug Rehabilitation Blog Posts Looks at 10 Tips for Coping After Drug or Alcohol Rehab 2Health News:CVS Caremark Adds New, Natural Acclaimed Hair Care Line to its Beauty Roster 2
... not to board a transatlantic flight with a potentially deadly ... and two Czechs who flew with him, media said ... scare two months ago when he flew to Montreal via ... Disease Control (CDC) had said he was infected with a ...
... operation for a rare birth defect has more than one share ... illegal immigrants in the U.S, have also been granted a ... daughter. ,Hazelle Roas little-known genetic abnormality left her with ... kept her in the hospital most of her life. According ...
... tattoo done of their lover's initials due to fear of ... - researchers have discovered a technique, where the cryptic body ... choice. ,The new method is called micro-encapsulation, where ... that are as tiny as pins, can bear a molecule ...
... of foods like white rice, pasta and bread, which ... macular degeneration (AMD). ,However, whole-wheat versions of ... have a low-glycemic-index. These foods are often considered higher ... and less dramatic rise and fall of blood sugar. ...
... turned nasty for a group of around ten ... , A Srilankan group of students who visited ... picnic organized by the Punqudutivu Students Association of Sri Lanka ... and abdominal cramps.,Toronto Public Health on Thursday confirmed six cases ...
... cash in on the Dutch laws. ,The former American ... cookie while touring in the Netherlands. ,"It was ... legal here. I don't ever do anything illegal here, People ... 25-year-old singer said that the cookie was an experiment and ...
Cached Medicine News:Health News:US TB Traveler Sued Over 'reckless and Selfish Behavior' 2Health News:Too Much White Rice, Pasta and Bread may Increase Chances of AMD 2Health News:Too Much White Rice, Pasta and Bread may Increase Chances of AMD 3
(Date:7/30/2014)... , July 30, 2014  There is ... chain organization,s success. The 10th Annual Institute for ... Awards for Excellence in Supply Management is open ... further the understanding and importance of supply management ... leadership and best supply management practices.  Entries are ...
(Date:7/30/2014)... -- CryoLife, Inc. (NYSE: CRY), a leading medical device ... surgery, announced today that its Board of Directors has ... 2014 of $0.03 per share of common stock outstanding.  ... be paid on September 19, 2014 to all common ... ex-dividend date for the quarterly dividend is September 10, ...
(Date:7/30/2014)... 2014 PuraMed BioScience ® , Inc., ... (OTC) medicinal and healthcare products, announced today that ... along with the name,s red and yellow logo. ... name MigraPure ®  going forward. The new ... natural migraine pain reliever will be reintroduced into ...
Breaking Medicine Technology:Institute for Supply Management, Michigan State University to recognize companies with excellent supply management practices 2CryoLife Announces Quarterly Cash Dividend for the Third Quarter 2014 2CryoLife Announces Quarterly Cash Dividend for the Third Quarter 2014 3PuraMed BioScience Rebrands its Natural Migraine Relief Medication, LipiGesic M 2PuraMed BioScience Rebrands its Natural Migraine Relief Medication, LipiGesic M 3
... Cyberonics, Inc. (Nasdaq: CYBX ), a global ... ended January 28, 2011.   Quarterly HighlightsOperating ... compared to the third quarter of fiscal 2010 include: ... U.S. net sales increased by 24%; U.S. epilepsy unit ...
... 1, 2011 Valeant Pharmaceuticals International, Inc. (NYSE: ... that Valeant Pharmaceuticals International ("Valeant"), its wholly owned indirect ... principal amount of senior unsecured notes (the "Notes"). ... Securities Act of 1933, as amended (the "Securities Act"), ...
Cached Medicine Technology:Cyberonics Reports Strong Fiscal 2011 Third Quarter Results and Increases Guidance 2Cyberonics Reports Strong Fiscal 2011 Third Quarter Results and Increases Guidance 3Cyberonics Reports Strong Fiscal 2011 Third Quarter Results and Increases Guidance 4Cyberonics Reports Strong Fiscal 2011 Third Quarter Results and Increases Guidance 5Cyberonics Reports Strong Fiscal 2011 Third Quarter Results and Increases Guidance 6Cyberonics Reports Strong Fiscal 2011 Third Quarter Results and Increases Guidance 7Valeant Launches Senior Notes Offering 2Valeant Launches Senior Notes Offering 3
... free flowing powder. pH: pH(4.7%, H 2 ... 24% Yeast Extract: 47% Potassium Phosphate Dibasic: 25% ... Dissolve 47 gm powder per liter of purified ... DNA and recombinant proteins than LB media by ...
12% Tryptone, 24% Yeast Extract, 4.0% Glycerol. Supplied with 1 liter of 10x phosphate buffer (0190-1L)....
5.0% Casein digest (NZ amine), 2.5% Sodium Chloride, 2.5% Yeast Extract....
1.0% Casein digest (NZ amine), 0.5% Sodium Chloride....
Medicine Products: