Navigation Links
Johns Hopkins researchers discover how some breast cancers alter their sensitivity to estrogen
Date:7/27/2011

Using human breast cancer cells and the protein that causes fireflies to glow, a Johns Hopkins team has shed light on why some breast cancer cells become resistant to the anticancer effects of the drug tamoxifen. The key is a discovery of two genetic "dimmer switches" that apparently control how a breast cancer gene responds to the female hormone estrogen.

In a report published online July 7 by Human Molecular Genetics, the scientists show how a gene known as RET in breast cancer cells responds to estrogen by dialing up the manufacture of a signaling protein that instructs cells to divide and causes tumors to become aggressive through the escape from estrogen dependence.

Scientists have long known that breast cancers are either estrogen-receptor positive or estrogen-receptor negative. The positive subset, generally associated with better outcomes for patients, is sensitive to the drug tamoxifen, which blunts aggressive tumor growth through estrogen receptor inhibition, according to Zachary E. Stine, the research team's lead author and a postdoctoral fellow working in the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine.

Used for decades to prevent and treat breast tumors that kill about 40,000 women a year, tamoxifen works on some types of breast cancers by interfering with the activity of estrogen. However, resistance to the drug frequently develops over time, and previous experiments by other laboratories have shown that RET plays some role in either altering resistance or maintaining it.

Thus, the Hopkins scientists focused on RET, searching for pieces of DNA in the vicinity of that gene that had the potential, when combined with estrogen, to act as switches controlling the amount of protein product RET manufactures.

After identifying 10 sites in the RET locus that bind with estrogen receptor alpha, the investigators cloned the DNA sequences in those areas,
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Jimmy Johnson Will Step Into Role as Honorary Crew Chief for ExtenZe Racing at Daytona
2. Protecting patients: Study shows that Johns Hopkins flu vaccination rates twice national average
3. Longtime Quality Assurance Executive Randy Johnson Joins White Pine Systems as Vice President of Product Services
4. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
5. AADR awards the 2010 Jack Hein Public Service Award to David C. Johnsen
6. Johnson & Johnson to Participate in RBC Capital Markets Health Care Conference
7. Robert Wood Johnson Foundation Launches New Scholars, Fellows & Leadership Programs Web Site
8. Johns Hopkins Launches “Energy Policy and Climate” Master's Degree
9. SC Johnson and Bill & Melinda Gates Foundation Unite to Combat Malaria
10. Johns Hopkins Health System Acquires Imorgon Ultrasound PACS Product
11. Cancer research award to Johns Hopkins basic scientist
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... San Diego, CA (PRWEB) , ... June 30, 2015 , ... ... Phillips, owner and founder of SunGrubbies.com. “We are particularly interested in getting the ... exposure can take years to surface. We are extremely pleased with our ...
(Date:6/29/2015)... ... June 30, 2015 , ... Sublime Beauty NATURALS® introduces its new USDA ... oil, ideal for natural skincare and even culinary uses, was especially designed for Oil ... people desire, and Oil Pulling can accomplish this. Oil Pulling is an Ayurvedic practice ...
(Date:6/29/2015)... Illinois (PRWEB) , ... June 30, 2015 , ... Aespala ... care team, board-certified plastic surgeon Dr. David Dreyfuss. , Dr. Dreyfuss received his ... Michael Reese Hospital in Chicago, followed by a Plastic Surgery Fellowship at the University ...
(Date:6/29/2015)... IL (PRWEB) , ... June 30, 2015 , ... Ticket ... show at Soldier Field over the 4th of July weekend. Concertgoers can add ... who have only recently caught on to their innovative sound, will not want to ...
(Date:6/29/2015)... ... June 30, 2015 , ... The ... for Neuro Musculoskeletal Thermography and Sympathetic Skin Response Studies.* , The new peer-reviewed ... published in 2006, are intended to aid physicians and thermal technologists in the ...
Breaking Medicine News(10 mins):Health News:SunGrubbies.com, a Leading Online Retailer of Sun Protection Products, Joins Effort to Promote Sun Safety 2Health News:SunGrubbies.com, a Leading Online Retailer of Sun Protection Products, Joins Effort to Promote Sun Safety 3Health News:New Product: Transform Wellness and Oral Health With This Ancient Ayurvedic Secret and Organic Product from Sublime Beauty NATURALS® 2Health News:Aespala Medspa and Plastic Surgery Welcomes New Plastic Surgeon to Oak Brook, IL Office 2Health News:Aespala Medspa and Plastic Surgery Welcomes New Plastic Surgeon to Oak Brook, IL Office 3Health News:Grateful Dead Tickets at Soldier Field in Chicago: Ticket Down Slashes Grateful Dead Tickets Prices in Chicago at Soldier Field 2Health News:Grateful Dead Tickets at Soldier Field in Chicago: Ticket Down Slashes Grateful Dead Tickets Prices in Chicago at Soldier Field 3Health News:American Academy of Thermology Publishes Revised 2015 Guidelines for Neuro-Musculoskeletal Thermography and Sympathetic Skin Response Studies 2Health News:American Academy of Thermology Publishes Revised 2015 Guidelines for Neuro-Musculoskeletal Thermography and Sympathetic Skin Response Studies 3
... ... used cosmetic lasers and other used aesthetic equipment by more than 30% to meet the ... to their patients. , ... Ft. Lauderdale, FL (PRWEB) July 9, 2010 -- The Laser Warehouse has increased its ...
... More than 3,000 ... Manhattan,s West Side in Riverside Park (at West 99th Street) for the 10th Annual Nautica New ... event expect to raise more than $2 million for various charities. , ... New York, NY (PRWEB) July 9, 2010 -- More than 3,000 ...
... ... RMSR Certification in 2002, the association has accredited certification bodies that represent ... Association of Medical Sales Representatives) RMSR Certification has been recently cited with ... named the sole approved accreditor of certification bodies for entry level Medical ...
... HealthDay Reporter , THURSDAY, July 8 (HealthDay News) -- ... may also raise the risk of developing squamous cell carcinoma, ... study suggests. The risk from human papillomavirus (HPV) seen ... taking drugs such as glucocorticoids to suppress the immune system, ...
... ... women with diminished ovarian reserve further confirms Center For Human Reproduction,s ongoing research on ... ... of Tel Aviv University in Tel Aviv, Israel, confirmed previously published research by New ...
... An ultra-low-molecular-weight heparin called semuloparin has been ... in orthopedic surgery patients in a large clinical ... by McMaster University professor Dr. Alexander Turpie. ... clinical studies on short-term venous thromboembolism (VTE) protective ...
Cached Medicine News:Health News:The Laser Warehouse Increases its Inventory of Used Cosmetic Lasers to Meet Growing Demand 2Health News:The Laser Warehouse Increases its Inventory of Used Cosmetic Lasers to Meet Growing Demand 3Health News:10th Annual Nautica New York City Triathlon Expects to Raise More Than $2 Million for Various Charities 2Health News:10th Annual Nautica New York City Triathlon Expects to Raise More Than $2 Million for Various Charities 3Health News:RMSR Certification Gains Medical Device & Equipment Industry Acceptance for Medical Sales Reps 2Health News:RMSR Certification Gains Medical Device & Equipment Industry Acceptance for Medical Sales Reps 3Health News:Study Suggests Link Between HPV, Skin Cancer 2Health News:Study Suggests Link Between HPV, Skin Cancer 3Health News:Tel Aviv University Fertility Research Confirms New York Center's DHEA Findings 2Health News:Tel Aviv University Fertility Research Confirms New York Center's DHEA Findings 3Health News:Drug study shows improvement in major orthopedic surgery care 2
(Date:6/29/2015)... SAN JOSE, Calif. , June 29, 2015 ... its expert medical workstation lineup. The high-powered, multi-functional ... th generation Intel® Haswell Core ... processor. Both provide significant data processing and computing ... visual performance, making the unit well suited for ...
(Date:6/29/2015)... June 29, 2015  Sorrento Therapeutics, Inc. (NASDAQ: ... added to the Russell 2000® Small Cap, Russell 3000®, ... occurred at the close of trading on June 26, ... set of U.S. and global indexes. Sorrento is already ... About the Russell Indexes. Russell ...
(Date:6/29/2015)... , June 29, 2015 /PRNewswire/-- CytRx Corporation (NASDAQ: ... specializing in oncology, today announced the presentation of interim ... evaluating the efficacy and safety of aldoxorubicin for the ... data will be presented on Wednesday, July 1, 2015 ... on Kaposi,s Sarcoma Herpesvirus (KSHV) and Related Agents in ...
Breaking Medicine Technology:Arbor Solution Introduces Multi-Function Medical Workstation with Large 21.5" True Flat Touch Screen 2Arbor Solution Introduces Multi-Function Medical Workstation with Large 21.5" True Flat Touch Screen 3Sorrento Added to Russell 2000 Small Cap, Russell 3000 and Global Indexes 2Sorrento Added to Russell 2000 Small Cap, Russell 3000 and Global Indexes 3CytRx Announces Presentation of Interim Phase 2 Data for Aldoxorubicin for HIV-Related Kaposi's Sarcoma 2CytRx Announces Presentation of Interim Phase 2 Data for Aldoxorubicin for HIV-Related Kaposi's Sarcoma 3CytRx Announces Presentation of Interim Phase 2 Data for Aldoxorubicin for HIV-Related Kaposi's Sarcoma 4CytRx Announces Presentation of Interim Phase 2 Data for Aldoxorubicin for HIV-Related Kaposi's Sarcoma 5CytRx Announces Presentation of Interim Phase 2 Data for Aldoxorubicin for HIV-Related Kaposi's Sarcoma 6
... GeoVax Labs, Inc. (OTCQB/OTCBB: GOVX), an ... Human Immunodeficiency Virus (HIV) infections, announced today the completion ... its HIV/AIDS vaccine. The vaccine is being developed for ... be exposed to the virus. The trial, designated HVTN ...
... CIVCO Medical Solutions is pleased to announce the ... Advanced Robotics and Workflow Solutions. Ramirez will be ... Robotic Patient Positioning System and RFSuite RFID Tracking ... http://photos.prnewswire.com/prnh/20110419/AQ85801LOGO ) "CIVCO is a leader ...
Cached Medicine Technology:GeoVax Phase 2a Clinical Trial Completes Enrollment 2GeoVax Phase 2a Clinical Trial Completes Enrollment 3GeoVax Phase 2a Clinical Trial Completes Enrollment 4CIVCO Appoints Andres Ramirez Sales Director of Advanced Robotics and Workflow Solutions 2
The model 55D Rocking Shaker provides the same Reliable quality as the 55S, but double the value. The 55D gives you an additional platform with a height of 3.25 in....
Multi-Tier Shaker...
... shake up to 16 of AutoGen's tube units ... This new system is most appropriate for bacterial ... digestion. Now you can further simplify your ... our AutoIncubator 96 and then placing our 6-hole ...
... incubators that are ideal for ... Microprocessor controlled heating and refrigeration ... audible and visual alarms with,remote ... safety thermostat,provides over-temperature protection.,Manual defrost ...
Medicine Products: