Navigation Links
Johns Hopkins leads first 16-patient, multicenter 'domino donor' kidney transplant
Date:7/7/2009

Surgical teams at The Johns Hopkins Hospital, Barnes-Jewish Hospital in St. Louis, INTEGRIS Baptist Medical Center in Oklahoma City and Henry Ford Hospital in Detroit successfully completed the first eight-way, multihospital, domino kidney transplant. The transplant involved eight donors 3 men and 5 women along with eight organ recipients 3 men and 5 women. "All Johns Hopkins patients are in good condition and are recovering as anticipated," according to Robert A. Montgomery, M.D., Ph.D., director of the Johns Hopkins Comprehensive Transplant Center.

The procedure, kidney paired donation (KPD), takes a group of incompatible donor-recipient pairs (recipients coming to one of the four hospitals with a willing donor who is not compatible by blood or tissue) and matches them with other pairs in a similar predicament. By exchanging kidneys between the pairs, it is possible to give each recipient a compatible kidney. In this way, each recipient receives a kidney from a stranger, and transplants are enabled that otherwise would not have taken place. Involving multiple hospitals created even more possibilities for matches, but it also made the procedure more complex.

"We performed a similar six-way domino procedure involving three hospitals earlier this year," says Montgomery. "We managed to perform all those surgeries on the same day. However, adding two more recipients, two more donors and another hospital meant that we needed a multihospital team of eight anesthesiologists, 16 nurses and nine surgeons. The logistics being that much more complicated, we decided it was best to spread the surgeries over several days, the first on June 15 and the last, July 6."

Aside from sheer logistics, performing large numbers of transplants on one day puts a lot of strain on the doctors, nurses and staff at each hospital, says Montgomery, and also ties up too many operating rooms.

He says this new model will serve as a blueprint for a national KPD program in which kidneys will be transported around the country, resulting in an estimated 1,500 additional transplants each year.

An altruistic donor started the domino effect. Altruistic donors are those willing to donate a kidney to any needy recipient. Just like falling dominoes, the altruistic donor kidney went to a recipient from one of the incompatible pairs, that recipient's donor's kidney went to a recipient from a second pair and so on. The last remaining kidney from the final incompatible pair went to a recipient who had been on the United Network for Organ Sharing (UNOS) waiting list.

One of the donors in this procedure was the Pamela Paulk, the vice president of human resources at The Johns Hopkins Hospital and Johns Hopkins Health System. Paulk, a long-time supporter of kidney donation, decided to donate to a friend and colleague who lost function of his kidneys three years ago.

"I always knew I was going to donate. I was just waiting for the right time, and this was the right time," says Paulk, whose surgery took place on June 22. Paulk joins roughly 100,000 Americans since 1988 who have generously donated a kidney to needy recipients, according to data from the UNOS Web site. As encouraging as that sounds, 84,000 people in the United States alone are currently listed by UNOS as needing a kidney. With only about 6,000 people donating kidneys annually, we are a long way from eliminating this problem, says Montgomery. For an up-to-date perspective from Paulk, please visit http://pameladonates.blogspot.com

As part of this complex procedure, Johns Hopkins flew one kidney to Henry Ford, one kidney to INTEGRIS Baptist and one kidney to Barnes-Jewish, In exchange, Henry Ford, INTEGRIS Baptists and Barnes Jewish each flew a kidney to Johns Hopkins.

The 16 surgeries were performed on four different dates, June 15, June 16, June 22 and July 6. The 10 surgeons in charge included four at Johns Hopkins, two at INTEGRIS Baptist, two at Barnes-Jewish and two at Henry Ford.

Johns Hopkins surgeons performed one of the first KPD transplants in the United States in 2001, the first triple-swap in 2003, the first double and triple domino transplant in 2005, the first five-way domino transplant in 2006 and the first six-way domino transplant in 2007. Johns Hopkins also performed the first multihospital, transcontinental three-way swap transplant in 2007 and the first multihospital, transcontinental six-way swap transplant in 2009.

Nearly 100 medical professionals took part in the transplants, including immunogeneticists, anesthesiologists, operating room nurses, nephrologists, transfusion medicine physicians, critical care doctors, nurse coordinators, technicians, social workers, psychologists, pharmacists, financial coordinators and administrative support people.


'/>"/>

Contact: John Lazarou
jlazaro1@jhmi.edu
410-502-8902
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. Bill Johnstone Named Senior Vice President of Crawfords Global Technical Services for the Americas
2. Johnson & Johnson to Host Analyst Conference Call on Second-Quarter Results
3. Predicting the return of prostate cancer: New Johns Hopkins study betters the odds of success
4. Johnson & Johnson and Elan Corporation plc Announce Definitive Agreement for Alzheimers Immunotherapy Program and Equity Investment
5. Beacon Equity Researches: Sanofi-Aventis, Amazon, Yahoo, Johnson & Johnson, Novavax and NexMed
6. SearchAmerica(R) President, Daniel Johnson, Named Ernst & Young Entrepreneur Of The Year(R)
7. Johns Hopkins Center for Communication Programs Honors MTV Executive for Outstanding Contribution to Health Communication
8. American Dental Hygienists Association and Johnson & Johnson Healthcare Products Division of McNEIL-PPC, Inc. Announce Honorees of HYGIENIST HERO(R) Recognition Program
9. Senator Johnson Votes to Protect Americas Kids from Tobacco
10. PHOENIX-AHF/Magic Johnson HIV Testing Caravan & Southwest Center for HIV/AIDS to Host Free HIV Testing Event at Off Chute Too
11. Patrick Johnston Named President and CEO of the California Association of Health Plans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... ... California and Nevada and LABS, Inc., announced the future opening of a CLIA ... screening and serology testing used to determine the suitability of potential organ ...
(Date:3/22/2017)... ... ... Wash Tower Ltd. has released a series of six viral poo-related teaser ... standalone constant pressure bidet. , The videos in the series titled "The Adventures of ... well as on its social media pages. , Each video stars Arthur the Butler ...
(Date:3/22/2017)... ... 2017 , ... The Rett Syndrome Research Trust (RSRT) announced ... afflicts 350,000 individuals worldwide. Rett Syndrome is caused by alterations in a ... Following a normal infancy, Rett Syndrome takes effect in toddlerhood depriving children ...
(Date:3/22/2017)... ... 2017 , ... Drs. Jennifer Houck, Lauren Smith, Heather Johnson and the India ... need of skilled pediatric dentistry in Rock Hill, SC, without a referral. ... treatments, including cavities, sealants and fluoride applications, in a comfortable and fun environment. , ...
(Date:3/22/2017)... , ... March 22, 2017 , ... ... entered into a research collaboration to translate advances in basic neuroscience at the ... Blythedale and beyond. The collaboration seeks to improve movement, vision, and cognition impaired by ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... -- DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... solutions, today reported financial and operational results for ... 31, 2016. 2016 Highlights ... compared to the full year 2015  ... year  Direct-to-consumer model launched in ...
(Date:3/22/2017)... today announced the appointment of Martyn Coombs as Chief ... ImaginAb, said "At ImaginAb we have exciting science and technology. Martyn ... business, particularly in commercializing and making step changes in the value ... our potential." ... Coombs is a recognized industry leader in nuclear medicine and imaging. ...
(Date:3/22/2017)... -- Ablation is the minimally invasive therapeutic tissue excision ... from cancerous or diseased tissue removal, to the ... fibrillation and others. The growing adoption of minimally ... and improvise existing ablation technologies for better patient ... is expected to grow at high single digit ...
Breaking Medicine Technology: