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Johns Hopkins GI doctors use endoscopy to place transpyloric stent
Date:7/3/2013

Physicians at Johns Hopkins say they are encouraged by early results in three patients of their new treatment for gastroparesis, a condition marked by the failure of the stomach to properly empty its contents into the small intestine. In an article published online today in the journal Endoscopy, they describe how the placement of a small metal stent in the stomach can improve life for people who suffer from severe bouts of nausea, abdominal pain and vomiting that accompany the condition.

John Clarke, M.D., assistant professor of medicine at the Johns Hopkins University School of Medicine, and the article's lead author, used an endoscope to place a pyloric stent in three patients with delayed gastric emptying. The pylorus is the part of the stomach that connects to the small bowel.

"I think this new technique could play a big role in the treatment of gastroparesis," says Clarke, who also is clinical director of the Johns Hopkins Center for Neurogastroenterology. "Though it sounds a little bit unconventional, the safety of it may be better than anything else we have out there."

Clarke says recently developed flexible, silicone-covered metal stents have already been approved to treat some gastrointestinal obstructions, but until now have not been used to treat gastroparesis.

Typically, patients with gastroparesis don't get a lot of good news from their physicians. Stomach surgery or risky medications such as erythromycin and metoclopramide have been the go-to treatments for the condition, which can have serious health and quality-of-life consequences.

"There are few FDA-approved options for gastroparesis patients," Clarke says. "The only medicines that are approved have a number of adverse effects associated with them."

The National Institutes of Health estimates that 5 million Americans live with gastroparesis, a condition in which the contents of the stomach empty into the intestine slowly or not a
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Contact: Patrick Smith
psmith88@jhmi.edu
410-955-8242
Johns Hopkins Medicine
Source:Eurekalert

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