Navigation Links
John Theurer Cancer Center researchers shed light on new multiple myeloma therapy
Date:7/25/2012

c disease. Patients received CRd induction therapy in 28-day cycles for up to eight cycles or until disease progression or unacceptable toxicity. After eight cycles, patients received maintenance CRd for up to 24 cycles and then moved to a single-agent lenalidomide.

During phase 1, the primary endpoints were safety and determination of the maximum tolerated dose of carfilzomib within the context of CRd combination therapy. Carfilzomib doses were escalated, while lenalidomide and dexamethasone were given at standard low-dose induction levels. Once the maximum tolerated dose of carfilzomib was reached, the researchers began Phase II with a primary endpoint of near complete response (nCR). Secondary endpoints were overall response rate, time on study, duration of response, progression-free survival (PFS), time to progression, overall survival and overall treatment toxicity.

Study results indicated that patients experienced a rapid and good initial response to CRd, and their responses improved as the trial continued. Of the 49 patients who completed four treatment cycles, 67 percent achieved at least nCR, with 45 percent in stringent complete response (sCR), defined as no detectable tumor cells or myeloma protein in the blood or bone marrow. Of the 36 patients who completed eight or more treatment cycles, 78 percent achieved nCR with 61 percent in sCR. Overall, 62 percent of trial participants achieved at least nCR, with 42 percent achieving sCR. The investigators also found PFS rates were 97 percent at 12 months and 92 percent at 24 months. All patients who achieved sCR continued to respond to therapy for a median of nine months, demonstrating the durability of responses to this regimen. Importantly, these periods of extended treatment were well tolerated, including low rates of peripheral neuropathy, a treatment-limiting side effect of bortezomib, the first-generation proteasome inhibitor.

Bortezomib is currently FDA approved to treat adv
'/>"/>

Contact: Amy Leahing
aleahing@p4strategy.com
305-458-0599
John Theurer Cancer Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Experts from John Theurer Cancer Center to participate in the AAMDSIF Patient and Family Conference
2. John Theurer Cancer Center hosting 8th Annual Neuro-Oncology Symposium
3. New probe provides vital assist in brain cancer surgery
4. Researchers find driver of breast cancer stem cell metastasis
5. Novel pig model may be useful for human cancer studies
6. Colonoscopy screening markedly reduces colorectal cancer incidence and death
7. A new route for tackling treatment-resistant prostate cancer
8. Antioxidants Might Help Cut Pancreatic Cancer Risk, Study Suggests
9. Young Cancer Patients Often Lack Support: Study
10. Media alert: 24th EORTC - NCI - AACR Symposium Molecular Targets and Cancer Therapeutics
11. Tel Aviv University research links childhood obesity to cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... (PRWEB) July 13, 2014 A ... & Schulte LLC to provide consumers with the most ... accompany use of the blood-thinning medication, as well as ... pending in courts around the country. The law firm ... may have suffered from life-threatening internal bleeding and related ...
(Date:7/13/2014)... 13, 2014 According to The Peripheral ... a comprehensive program that teaches people how to deal ... without medications. This program also provides people with ... peripheral neuropathy , including numbness, prickling, burning, and intense ... that this home treatment program can help people eliminate ...
(Date:7/12/2014)... iFitDress.com, one of the world’s leading wedding dress suppliers, has ... What’s more, all these hot outfits are available at discounted ... states, “We are proud to announce our new red evening ... experience. In addition to the big discounts, low shipping costs ... always mean bad quality. All the red evening gowns are ...
(Date:7/12/2014)... 2014 The report, "Phthalic Anhydride and ... by Application & Geography – Trends & Forecast to ... and forecasting of market volume and value. The report ... separately. The market of phthalic anhydride is projected to ... $8,415.89 million by 2018, with a CAGR of 5.24% ...
(Date:7/12/2014)... The Security Analytics market is estimated to ... by 2019, at an expected CAGR of 9.7% for ... counter the increasing number of security breaches, continued line ... systems in organizations are enormous. Vendors in the security ... architecture to develop better and more secure systems. , ...
Breaking Medicine News(10 mins):Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 2Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 3Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 4Health News:The Peripheral Neuropathy Program Review Exposes Randall Labrum's Peripheral Neuropathy Treatment Program – Vkool.com 2Health News:The Peripheral Neuropathy Program Review Exposes Randall Labrum's Peripheral Neuropathy Treatment Program – Vkool.com 3Health News:Discounted Red Evening Gown Announced by iFitDress.com 2Health News:Phthalic Anhydride Market Projected to Reach $8.42 Billion by 2018 – Report by MarketsandMarkets 2Health News:Phthalic Anhydride Market Projected to Reach $8.42 Billion by 2018 – Report by MarketsandMarkets 3Health News:Phthalic Anhydride Market Projected to Reach $8.42 Billion by 2018 – Report by MarketsandMarkets 4Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 4
... 25 The Akron General Health System, a,nationally ... and,wellness, is accepting nominations for its second annual ... individuals and,corporations/organization -- throughout the State of Ohio ... or the health of their,employees., Nominations for ...
... know that there,s a new infant formula that blocks ... Vitamin D status during pregnancy will affect her baby,s ... syrup that prevents early-childhood tooth decay? ,These are but ... which will be presented when the International,Association for Dental ...
... Viral video communicates the importance of skin cancer ... Neutrogena(R) Partnership for,Skin Health, a public service initiative ... advancements and explore solutions for,skin health, has tapped ... video about self-examination for skin cancer detection. As ...
... National Association of Health Care Assistants Delivers Letter ... to Seniors, Nursing Home,Care, JOPLIN, Mo., June ... (NAHCA) -- representing the voice of,more than 20,000 ... 29 states and,the District of Columbia -- delivered ...
... in German . , Oregano doesnt only ... and the ETH Zrich have discovered that this spice also ... cure inflammations. The researchers administered its active ingredient known ... seven out of ten cases there was a subsequent improvement ...
... is a national concern that led the U.S. surgeon ... and Reduce Underage Drinking" ( http://www.surgeongeneral.gov/topics/underagedrinking/ ) last year. ... researcher assesses the effectiveness of underage drinking prevention programs ... key goals outlined by the surgeon general. , Lead ...
Cached Medicine News:Health News:Statewide Wellness Awards Competition Now Open for Nominations 2Health News:International Dental Research Association meets in Toronto 2Health News:International Dental Research Association meets in Toronto 3Health News:International Dental Research Association meets in Toronto 4Health News:Neutrogena(R) Partnership For Skin Health Taps Malin Akerman to Educate About Skin Cancer Detection 2Health News:Neutrogena(R) Partnership For Skin Health Taps Malin Akerman to Educate About Skin Cancer Detection 3Health News:Nation's Health Care and Nursing Assistants Urge HHS to Withdraw Proposed $770 Million Funding Cut to Skilled Nursing Care 2Health News:Salutary pizza spice 2Health News:Pediatrics review of underage drinking prevention programs led by Iowa State researcher 2Health News:Pediatrics review of underage drinking prevention programs led by Iowa State researcher 3
(Date:7/11/2014)... -- Neurelis, Inc. ("Neurelis") today announced an agreement with ... by Biotie to purchase Neurelis, clearing the way for ... for pediatric and adult epilepsy patients who experience acute ... has advanced the development program for NRL-1 and worked ... required for NDA submission to the FDA.  Given the ...
(Date:7/10/2014)... -- Integrated Silicon Solution, Inc. (Nasdaq: ISSI ... solutions, today announced that it will host its earnings ... a.m. Pacific Time (10:00 a.m. Eastern Time) to discuss ... quarter ended June 30, 2014. To access ... a.m. Pacific time on July 24, 2014.  The participant ...
(Date:7/10/2014)... --  Ventana Medical Systems, Inc.  (Ventana), a member of ... an agreement with Merck KGaA, Darmstadt, Germany ... the United States and ... division on the development and commercialization of a companion ... diagnostic assays. In alignment with Merck KGaA,s strategic approach ...
Breaking Medicine Technology:Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3
... Takeda Pharmaceuticals International, Inc., a wholly-owned subsidiary ... its Pharmaceutical Development Division has entered into strategic ... and Quintiles, two of the world,s largest full-service ... the agreements, Covance and Quintiles will work in ...
... Viral Genetics, Inc. (Pink Sheets: VRAL ) ... and Advisor Mr. Richard Gerstner will receive the Lauren F. ... award presentation is set for the Illusions of Lyme Gala, ... being recognized for her research on Targeted Peptide treatment for ...
Cached Medicine Technology:Takeda Enters Into Global Strategic Partnerships With Covance and Quintiles 2Viral Genetics' Researcher and Advisor Set to Share Award 2Viral Genetics' Researcher and Advisor Set to Share Award 3