Navigation Links
John Theurer Cancer Center researchers shed light on new multiple myeloma therapy
Date:7/25/2012

available to patients with advanced-stage multiple myeloma and the diminished prospects for retreatment once an agent has been utilized, we believe there is a significant need in this patient population."

Two hundred and sixty-six patients received single agent carfilzomib twice weekly for 3 out of 4 weeks. The study's primary endpoint was overall response rate (ORR; ≥partial response) and secondary endpoints included clinical benefit response rate (≥minimal response), duration of response (DOR), time to progression, progression-free survival, overall survival (OS), and safety.

ORR was 23.7 percent with median DOR of 7.8 months. Median OS was 15.6 months. Adverse events (AEs) were manageable without cumulative toxicities. The researchers concluded that durable responses and an acceptable tolerability profile in this heavily-pretreated population demonstrate the potential of carfilzomib to offer meaningful clinical benefit.

Phase 1/2 Results for Frontline Therapy for Newly Diagnosed Multiple Myeloma Patients

David H. Vesole, M.D., Ph.D., F.A.C.P., Co-Chief and Director of Research served as co-author of a study published on June 4th in Blood, which involved researchers from six leading cancer centers. The multi-center, open-label phase 1/2 study looked at carfilzomib in combination with lenalidomide and low-dose dexamethasone (CRd) as a frontline treatment for multiple myeloma.

"Triple-agent regimens with bortezomib, lenalidomide, and/or thalidomide are currently the preferred frontline strategy for newly diagnosed multiple myeloma. However, maintaining dose levels over time can be limited by the treatments' emerging toxicities," said Dr. Vesole. "This study demonstrated that the combination of carfilzomib, lenalidomide and dexamethasone is well tolerated and highly active for these patients."

The researchers enrolled 53 patients with newly-diagnosed multiple myeloma who had symptomati
'/>"/>

Contact: Amy Leahing
aleahing@p4strategy.com
305-458-0599
John Theurer Cancer Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Experts from John Theurer Cancer Center to participate in the AAMDSIF Patient and Family Conference
2. John Theurer Cancer Center hosting 8th Annual Neuro-Oncology Symposium
3. New probe provides vital assist in brain cancer surgery
4. Researchers find driver of breast cancer stem cell metastasis
5. Novel pig model may be useful for human cancer studies
6. Colonoscopy screening markedly reduces colorectal cancer incidence and death
7. A new route for tackling treatment-resistant prostate cancer
8. Antioxidants Might Help Cut Pancreatic Cancer Risk, Study Suggests
9. Young Cancer Patients Often Lack Support: Study
10. Media alert: 24th EORTC - NCI - AACR Symposium Molecular Targets and Cancer Therapeutics
11. Tel Aviv University research links childhood obesity to cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... older adults on five continents found that nearly 1 ... simple test that measures how fast people walk and ... for pre-dementia were twice as likely as others to ... scientists at Albert Einstein College of Medicine ... was published online on July 16, 2014 in ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 Hastings and ... offering discount attorney’s fees with regard to personal injury ... provide a wide range of legal services for those ... negligence of another individual or corporation. Free initial consultation ... the validity of a potential personal injury claim ...
(Date:7/25/2014)... 2014 As thousands of transvaginal mesh ... Bernstein Liebhard LLP notes that the Food & Drug ... advocacy group, Public Citizen, to order a global recall ... May 1, 2014, and released to the public last ... a ban on the marketing of all surgical mesh ...
(Date:7/25/2014)... FRIDAY, July 25, 2014 (HealthDay News) -- Babies seem ... suggests. By the time women are 34 weeks ... of their mother,s voice reciting a familiar nursery rhyme, ... predominant source of sensory stimulation in the developing fetus," ... University of Florida,s College of Nursing, said in a ...
(Date:7/25/2014)... vulnerable neurons and reduce motor deficits in a ... University School of Medicine have shown. , The ... Parkinson,s Disease . , The findings demonstrate that ... at sufficient levels and have beneficial effects when ... Previous studies of XPro1595 in animals tested more ...
Breaking Medicine News(10 mins):Health News:Slow walking speed and memory complaints can predict dementia 2Health News:Slow walking speed and memory complaints can predict dementia 3Health News:Slow walking speed and memory complaints can predict dementia 4Health News:Hastings and Hastings Announces Complimentary Consultation Services 2Health News:Hastings and Hastings Announces Complimentary Consultation Services 3Health News:Transvaginal Mesh Lawsuit News: FDA Rejects Petition Seeking Ban and Global Recall of All Transvaginal Mesh Products, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: FDA Rejects Petition Seeking Ban and Global Recall of All Transvaginal Mesh Products, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuit News: FDA Rejects Petition Seeking Ban and Global Recall of All Transvaginal Mesh Products, Bernstein Liebhard LLP Reports 4Health News:Rhymes Reveal Evidence of Learning in the Womb 2Health News:Anti-inflammatory drug can prevent neuron loss in Parkinson's model 2
... Children exposed to chlorpyrifos-an insecticide, while in their mother’s ... by three years of age and also have a// ... in a peer-reviewed study conducted by Academy of Pediatrics. ... use in 2001, is still widely applied to agricultural ...
... Britain's heart experts are hoping to exploit the passion for ... people from the community not to delay calling// emergency help ... Asians in Britain have a 40-50 per cent higher death ... Asians are known to be reluctant to seek emergency help ...
... Meet organized by the city board of health on 5th ... use of Trans fat in the commercially prepared foods such ... Frieden, the health commissioner said, 'We hope that the board ... into consideration the concerns raised by 24,000 restaurateurs in New ...
... about chicken, which finds itself in the news, for all ... be hounded incessantly by germs. ,When Consumer reports ... 83% of the chickens were infected with either the campylobacter ... trigger diarrhea, cramping, nausea, fever, and vomiting, and can be ...
... A new study finds that the anti-craving drug, Naltrexone ... women who are trying to quit smoking appear //to ... individualized medicine, scientists are focusing on gender differences in ... Andrea King and her colleagues of the University of ...
... gained new ground to prove that your moms' advice, to eat ... best for you! If you chew your food well and take ... feeling better, says a new study. , Kathleen ... of this study. She compared the intake of calories of two ...
Cached Medicine News:Health News:Chlorpyrifos Affects Mental Development of Foetus 2Health News:British Heart Experts Use Cricket To Target South Asians 2
(Date:7/25/2014)... July 25, 2014 GrowBLOX Sciences, Inc. (OTCQB: GBLX) ... of Understanding ("MOU") with LaurelCo, LLC, an Illinois ... of both cultivation and dispensary medical marijuana licenses in the ... MOU, GBLX will acquire a 20% equity interest in LaurelCo, ... TM growing chambers, as well as all technology related ...
(Date:7/25/2014)... HOUSTON , July 25, 2014  Solanbridge Group ... has acquired the majority interest in Buzznbrewz.com and the ... been replaced with a fully executed Purchase Agreement. ... Solanbridge, stated "We are proud to have Mr. ... has decades of experience in the private sector and ...
(Date:7/25/2014)... -- IDEXX Laboratories, Inc. (NASDAQ: IDXX ) today ... increased 11% versus the prior year period to $390 ... quarter of 2014 versus the prior year period was ... 2 . Earnings per diluted share ("EPS") for the ... prior year period to $1.10."In the second quarter, we ...
Breaking Medicine Technology:GrowBLOX Sciences, Inc. Partners with LaurelCo, LLC to Obtain Licenses to Cultivate and Dispense Medical Marijuana in Illinois 2GrowBLOX Sciences, Inc. Partners with LaurelCo, LLC to Obtain Licenses to Cultivate and Dispense Medical Marijuana in Illinois 3Solanbridge Group Inc Announces Acquisition of Buzznbrewz.com 2IDEXX Laboratories Announces Second Quarter Results 2IDEXX Laboratories Announces Second Quarter Results 3IDEXX Laboratories Announces Second Quarter Results 4IDEXX Laboratories Announces Second Quarter Results 5IDEXX Laboratories Announces Second Quarter Results 6IDEXX Laboratories Announces Second Quarter Results 7IDEXX Laboratories Announces Second Quarter Results 8IDEXX Laboratories Announces Second Quarter Results 9IDEXX Laboratories Announces Second Quarter Results 10IDEXX Laboratories Announces Second Quarter Results 11IDEXX Laboratories Announces Second Quarter Results 12IDEXX Laboratories Announces Second Quarter Results 13IDEXX Laboratories Announces Second Quarter Results 14IDEXX Laboratories Announces Second Quarter Results 15IDEXX Laboratories Announces Second Quarter Results 16IDEXX Laboratories Announces Second Quarter Results 17IDEXX Laboratories Announces Second Quarter Results 18IDEXX Laboratories Announces Second Quarter Results 19IDEXX Laboratories Announces Second Quarter Results 20IDEXX Laboratories Announces Second Quarter Results 21IDEXX Laboratories Announces Second Quarter Results 22IDEXX Laboratories Announces Second Quarter Results 23IDEXX Laboratories Announces Second Quarter Results 24IDEXX Laboratories Announces Second Quarter Results 25IDEXX Laboratories Announces Second Quarter Results 26IDEXX Laboratories Announces Second Quarter Results 27IDEXX Laboratories Announces Second Quarter Results 28IDEXX Laboratories Announces Second Quarter Results 29IDEXX Laboratories Announces Second Quarter Results 30IDEXX Laboratories Announces Second Quarter Results 31IDEXX Laboratories Announces Second Quarter Results 32IDEXX Laboratories Announces Second Quarter Results 33
... Technology Applicable for the Detection of a Host of Amyloid Neurological ... ... Parkinson Disease, ROCKVILLE, Md., Aug. 29 Adlyfe, a ... announced today the publication of a study, "Detection of,misfolded prion protein ...
... 28 Gilbert Hospital is,the first hospital in ... in,extracorporeal shockwave lithotripsy in the fight against painful ... waves in a,non-invasive procedure to break down kidney ... System has been added to Gilbert,Hospital,s arsenal of ...
Cached Medicine Technology:Adlyfe Study on the Detection of Misfolded Proteins Published in the Journal Transfusion 2Adlyfe Study on the Detection of Misfolded Proteins Published in the Journal Transfusion 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: