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John P. Cogswell, Ph.D., receives 2009 Alzheimer Award
Date:5/26/2009

need for diagnostic biomarkers of disease progression this paper additionally examines the microRNAs in the cerebrospinal fluid of late stage AD patients. Again AD-specific changes were detected although here microRNAs with known and potential combinatorial effects on T lymphocyte signaling and inflammation pathways were identified. Because the CSF contains memory T cells and antigen presenting cells involved in immune-surveillance of the brain, these data suggested that microRNA responses in CSF cells might be sentinels of the disease.

"More work is required to validate whether these changes are specific to AD, can be used to follow the course of AD or overlap with other neurodegenerative diseases involving inflammation," stated Dr. Cogswell. "However, the data highlight the potential of microRNAs to further understand sporadic Alzheimer's disease and provide accessible biomarkers to aid clinical diagnosis."

Dr. Cogswell, a former researcher at GlaxoSmithKline Inc., Research Triangle Park, NC, received his initial training from Duke University, Durham, North Carolina followed by postdoctoral fellowships in cellular and molecular immunology at the University of California, Los Angeles and University of North Carolina, Chapel Hill. In 16 years at GSK, Dr. Cogswell and colleagues developed high content qRT-PCR and histology applications that identified tractable targets from the human genome sequencing project and transcriptional biomarkers that decreased attrition in drug discovery.


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Contact: Astrid Engelen
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Source:Eurekalert

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