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John P. Cogswell, Ph.D., receives 2009 Alzheimer Award
Date:5/26/2009

May 26, 2009, Amsterdam, The Netherlands and San Antonio, TX, USA John P. Cogswell, PhD, has been chosen as the recipient of the 2009 Alzheimer Award presented by the Journal of Alzheimer's Disease in recognition of his outstanding work, "Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways" (J Alzheimers Dis 14: 27-41, 2008) by J.P. Cogswell et al.

"My co-authors and I are extremely pleased to have been chosen by a distinguished group of our peers as the recipients of this year's Journal of Alzheimer's Disease award for our work on the use of biomarkers in the diagnosis of AD," said Dr. Cogswell.

Each year the Associate Editors of the Journal of Alzheimer's Disease select an outstanding article from the previous year's volume to receive this prestigious award, which is made possible by support from IOS Press and Elan Pharmaceuticals. Dr. Cogswell will be presented with the bronze Alzheimer Medal with the likeness of Alois Alzheimer and a cash award.

Dr. Cogswell's work examines changes in microRNA expression and their role in the sporadic form of the disease. MicroRNAs are small regulatory RNAs that affect many basic cellular and biological processes. They are best known for regulating RNA and protein expression in pathways and networks due to the combinatorial binding potential between microRNAs and their targets. Using a sensitive and specific qRT-PCR technology this paper demonstrates altered expression of specific microRNAs in the brain of Alzheimer's disease (AD) subjects. The changes were both dependent and independent of the pathological changes with some detected quite early in the disease. Many of the microRNAs have functional roles in known AD pathways including neuronal differentiation, glutamate, and innate immunity although the potential combinatorial effects on insulin signaling were noteworthy.

Because of the
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Contact: Astrid Engelen
a.engelen@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

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