Navigation Links
Jekyll into Hyde: Breathing auto emissions turns HDL cholesterol from 'good' to 'bad'
Date:5/15/2013

Academic researchers have found that breathing motor vehicle emissions triggers a change in high-density lipoprotein (HDL) cholesterol, altering its cardiovascular protective qualities so that it actually contributes to clogged arteries.

In addition to changing HDL from "good" to "bad," the inhalation of emissions activates other components of oxidation, the early cell and tissue damage that causes inflammation, leading to hardening of the arteries, according to the research team, which included scientists from UCLA and other institutions.

The findings of this early study, done in mice, are available in the online edition of the journal Arteriosclerosis, Thrombosis and Vascular Biology, a publication of the American Heart Association, and will appear in the journal's June print edition.

Emission particles such as those from vehicles are major pollutants in urban settings. These particles are coated in chemicals that are sensitive to free radicals, which have been known to cause oxidation. The mechanism behind how this leads to atherosclerosis, however, has not been well understood.

In the study, the researchers found that after two weeks of exposure to vehicle emissions, mice showed oxidative damage in the blood and liver damage that was not reversed after a subsequent week of receiving filtered air. Altered HDL cholesterol may play a key role in this damaging process, they said.

"This is the first study showing that air pollutants promote the development of dysfunctional, pro-oxidative HDL cholesterol and the activation of an internal oxidation pathway, which may be one of the mechanisms in how air pollution can exacerbate clogged arteries that lead to heart disease and stroke," said senior author Dr. Jesus Araujo, an associate professor of medicine and director of environmental cardiology at the David Geffen School of Medicine at UCLA.

For the study, one group of mice was exposed to vehicl
'/>"/>

Contact: Rachel Champeau
rchampeau@mednet.ucla.edu
310-794-2270
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Chef Jekyll Advises on Lunch at the Beach
2. Chef Jekyll to Show off Home-Grown Herbs at Second Annual Props, Wings and Wheels Extravaganza
3. Chef Jekyll to Be Featured at Second Annual Taste of North Bay
4. Many Americans Breathing Cleaner Air: Report
5. Bend, Oregon Resident Named to Board of Directors and Elected Vice-Chairman of Buteyko Breathing Educators Association
6. Breathing Problem Sometimes Misdiagnosed in Athletes
7. Spiro PD Personal Spirometer Helps People Track Their Breathing Disorders As Generally Mild Winter Signals Early Allergy Season
8. Dr. Steve Carstensen Presents First Webinar for Dental Division of American Sleep and Breathing Academy
9. Inserting Breathing Tube May Not Be Best for Victims of Cardiac Arrest
10. Treating sleep-disordered breathing in pregnancy may improve fetal health
11. Benefits of higher oxygen, breathing device persist after infancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... Acne is a common problem millions of American ... more than a daily nuisance, for some, it can have a ... can even lead to dramatic mood swings and depression. , ... clear up their skin. In some cases, that can make the ... and error, those on a quest for clearer skin can now ...
(Date:8/30/2014)... August 30, 2014 Continuing to meet ... is expanding with the addition of a new doctor ... who has provided leading-edge skin care in Grand Rapids ... , “As a doctor, my passion is making ... partnering with Forefront Dermatology, I’m better able to focus ...
(Date:8/30/2014)... medication commonly used to treat gout, before and ... potential complications from this type of surgery, but ... effects, according to a study published by ... online to coincide with its presentation at the ... after cardiac surgery include postpericardiotomy syndrome (the occurrence ...
(Date:8/30/2014)... New York, New York (PRWEB) August 30, 2014 ... consolidated litigation for transvaginal mesh lawsuits ( http://www.injurybeacon.com/transvaginal-mesh/ ... the company’s request to sever four cases selected ... to an Order issued on August 18, 2014, ... Southern District of West Virginia disagrees with Boston ...
(Date:8/30/2014)... August 30, 2014 One of the most ... is the gluten-free diet. Originally meant for sufferers of gluten ... catchall for people who are looking to get healthier by ... only is this kind of information erroneous, it also exposes ... because of a drastic change in their food consumption ...
Breaking Medicine News(10 mins):Health News:Acne Treatment Reviews Added to Popular Treatment Website 2Health News:Expanding Care at the Forefront of Dermatology 2Health News:Medication shows mixed results in reducing complications from cardiac surgery 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 3Health News:“What is Gluten: Three Things You Need to Know Before Adopting a Gluten-Free Diet” Reveals What Readers Need to Know About the Benefits of a Strict Gluten Diet - Vinamy 2
... a Rich Source to Fill the "E Gap", ... the U.S. population does not meet the current intake,recommendation ... the,September 2008 Journal of Nutrition(). The article recognized almonds ... this nutrient gap and the,authors concluded that vitamin E, ...
... Receive Benefits of, Member Emergency Assistance Plans to ... 11 As predictions increase for Hurricane,Ike to become ... the Texas Gulf Coast,Blue Cross and Blue Shield of ... may potentially be affected., "Quick access to health ...
... CHENGDU, China, Sept. 11 /Xinhua-PRNewswire-FirstCall/ -- Tianyin,Pharmaceutical, ... manufacturer and,supplier of modernized traditional Chinese medicine ... the Company has received approval from,the Chinese ... produce Laonian,Kechuan Tablets in the dosage form ...
... the Delft University of Technology in the Netherlands, global shortages ... of the past. This is the message from Prof. Bert ... in an article in university journal Delta . ... a shortage of radio isotopes which means that patients will ...
... serious consequences for the children,s growth, health, and survival. ... women and their children in Bangladesh and Nicaragua and ... exposed to violence grow less and are sick more ... paediatrician, the Department of Women,s and Children,s Health, monitored ...
... and global marketer of vascular access and fluid ... four weeks after the company,s introduction of its ... from Boston Scientific. They are: 1) an ... inudstry,s only dual-safety EZ Huber® Infusion Needle Set; ...
Cached Medicine News:Health News:E-mergency? Majority of U.S. Consumers Lack Essential Vitamin E 2Health News:Preparations by Blue Cross and Blue Shield of Texas Will Assist Members Affected by Hurricane Ike 2Health News:Tianyin Pharmaceutical Co., Inc. Receives Chinese SFDA Approval for Laonian Kechuan Tablets 2Health News:Tianyin Pharmaceutical Co., Inc. Receives Chinese SFDA Approval for Laonian Kechuan Tablets 3Health News:Delft University of Technology patent for manufacturing radio isotopes 2Health News:New Vascular Access Medical Devices Launched by Navilyst Medical 2Health News:New Vascular Access Medical Devices Launched by Navilyst Medical 3Health News:New Vascular Access Medical Devices Launched by Navilyst Medical 4Health News:New Vascular Access Medical Devices Launched by Navilyst Medical 5
(Date:8/29/2014)... , Aug. 29, 2014  BC Technical, the ... acquired Polaris Medical Imaging, a leader in sales, service ... strategic acquisition allows BC Technical to continue to expand ... within MR and CT modalities. "We ... said Mark Alvarez , president and CEO of ...
(Date:8/29/2014)... Does your doctor know what you,re smoking?  Chances ... marijuana to the over 112,000 currently registered patients under ... the other roughly 20,300+ active physicians listed with the Colorado ... – even though a poll in February 2014 showed 51% ... tried it. "With marijuana legalization underway, every ...
(Date:8/29/2014)... WASHINGTON , Aug. 29, 2014 Diseases ... a generation ago are returning. Measles was declared ... cases in 2014 as of August 15—the highest incidence ... public health department declared whooping cough a problem ... children are getting sick and dying from these preventable ...
Breaking Medicine Technology:BC Technical Acquires Polaris Medical Imaging 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3
... (Nasdaq: THOR ), a world leader in ... restore failing hearts, said today that it will be ... On Wednesday, September 22, Thoratec will participate in the ... vice president and chief financial officer, will provide an ...
... 16 Arena Pharmaceuticals, Inc. (Nasdaq: ARNA ... Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs ... data do not adequately demonstrate that the potential benefits ... in a population of overweight and obese individuals to ...
Cached Medicine Technology:Thoratec to Present at Upcoming Investor Conferences 2Arena and Eisai Provide Update on Lorcaserin FDA Advisory Committee Meeting 2Arena and Eisai Provide Update on Lorcaserin FDA Advisory Committee Meeting 3Arena and Eisai Provide Update on Lorcaserin FDA Advisory Committee Meeting 4
... most comprehensive family of lightweight standard ... incision, Glaucoma filtration, and Vitreoretinal uses. ... with minimal tissue trauma and minimal ... are available in 18, 20, and ...
... Centuries of German Craftsmanship have ... in the world. Ocutek now ... Only holders of the coveted ... eight-year apprenticeship, are qualified to ...
... Centuries of German Craftsmanship ... instrumentation in the world. Ocutek ... you! Only holders of the ... and eight-year apprenticeship, are qualified ...
... German Craftsmanship have produced the ... world. Ocutek now makes them ... of the coveted Meisterbrief certificate, ... are qualified to become Ocutek ...
Medicine Products: