Navigation Links
'Jekyll and Hyde' Factor May Control Insulin Function
Date:3/29/2010

Finding could lead to new diabetes treatments, researchers say

MONDAY, March 29 (HealthDay News) -- A "Jekyll and Hyde" protein involved in both insulin action and insulin resistance has been identified by U.S. researchers.

It's long been known that an enzyme called PI 3-kinase plays an important role in the main molecular pathway for insulin signaling in cells.

In tests on cells and genetically modified mice, Joslin Diabetes Center researchers found that a protein (p85) in the PI 3-kinase enzyme drives a pathway with an opposite effect -- triggering a stress response that causes insulin resistance, a precursor to diabetes.

"The p85 protein has a kind of yin-yang effect, functioning both as an important link in insulin action and an important link to insulin resistance," the study's senior author, Dr. C. Ronald Kahn, head of the integrative physiology and metabolism section at Joslin, said in a news release from the center.

The study was published March 28 in Nature Medicine.

There are two protein subunits (p85 and p110) in Pl 3-kinase.

"The p85 molecule is like Dr. Jekyll and Mr. Hyde," Kahn said. "One end of the molecule binds to p110, forming a key pathway that is needed for the metabolic effect of insulin on glucose metabolism. The other end of p85 is doing mischief" by interacting with a protein that causes a stress response that's a major factor in insulin resistance.

The finding may offer new targets for developing drugs that target insulin resistance.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about insulin resistance.



-- Robert Preidt



SOURCE: Joslin Diabetes Center, news release, March 28
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New research identifies modifiable risk factors for heart disease
2. Melatonin precursor stimulates growth factor circuits in brain
3. Growth factor gene shown to be a key to cleft palate
4. Salesforce CRM Users Outperform Past Results by a Factor of at Least 50%
5. Study Shows Cigarette Smoking a Risk Factor for Alzheimer's Disease
6. Early Factors Predict Later-Life Stroke Risk, from the Harvard Health Letter
7. 3 key factors to help children avoid social rejection identified
8. For Heart Health, Focus on Risk Factors
9. Mexican Dental Vacation Sees a Rush Of New Patients: Recession A Factor
10. Transplant guide highlights daily infection risks from factors like pets and food
11. Patient Factors Mar Accuracy of Multi-Detector CT Scans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... "I have been ... Place, N.Y. "I specialize in manual therapy, and my invention will provide headache ... used for additional muscle dysfunction throughout the body." , They developed THE RELIEVER ...
(Date:8/29/2015)... ... ... Dr. Tim Novelli, DC., Founder and President of the Patriot Project, is a ... field in the military. All too often VA hospitals treat patients with harmful and ... the VA program over a decade ago, the reality is that only 10% of ...
(Date:8/29/2015)... ... 29, 2015 , ... ProDrop Particles includes over 40 particle backdrops designed for ... unique footage that users can shrink and stretch in the Final Cut Pro X ... customize color, brightness, scale, speed, range, and flare attributes with intuitive controls found in ...
(Date:8/29/2015)... ... 29, 2015 , ... The popular television program VOICES IN AMERICA, hosted by ... will be devoting an entire short segment to the subject of diabetes. Diabetes is ... on a daily basis, but recent advancements in medical science may prove to be ...
(Date:8/28/2015)... Madre, CA (PRWEB) , ... August 28, 2015 ... ... solutions to wound center management, Decatur County Memorial Hospital recently transitioned management companies ... model of Wound Center Management for their outpatient wound center. , Transitioning ...
Breaking Medicine News(10 mins):Health News:Inventors and InventHelp Clients Develops Tension Reliever (LGI-1951) 2Health News:The Patriot Project brings Chiropractic Care to the Armed Forces and their Families - Rapid Release Technology Joins the Effort to Recruit more Doctors to Pledge 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 4
... , WASHINGTON, Sept. 18 The ... every VA medical site with endoscopic equipment, independently verifying the ... and sterile procedures for reprocessing endoscopic equipment across the country. ... provide the highest quality care to the Veterans of this ...
... in hospital patients also leads to higher costs, study ... popular stomach acid reducer greatly increases the risk of ... study has found. , Researchers at Wake Forest University ... of 834 cardiothoracic surgery patients on breathing machines who ...
... , WASHINGTON, Sept. 18 In response to the ... Max Baucus, DMLR Chairman Stuart L. Weinstein, M.D. issued the following ... Baucus is inadequate in addressing the serious problems caused by medical ... health care policy experts, opinion leaders, and patients all across the ...
... , , , WEINER,S NEW YORK ... , WASHINGTON, Sept. 18 The Public Option is still ... ,fading, nor ,waning, (New York Times) nor on ,life support, (ABC News)," says ... Health subcommittee, and later spokesman for the White House National Drug Policy Office. ...
... , , IDAHO FALLS, Idaho, ... announces the successful conclusion of a private placement completed among ... International Isotopes Inc. successfully completed a private placement ... $1 million. In this private placement, the Company offered ...
... N.Y., Sept. 18 IPRO has won a new ... research findings aimed at improving the quality and safety ... Agency for Healthcare Research and Quality,s (AHRQ,s) Knowledge Transfer/Implementation ... accelerated dissemination of evidence-based products that improve the quality ...
Cached Medicine News:Health News:Inspector General Completes Study of VA Endoscopic Programs 2Health News:Ulcer Preventative May Raise Pneumonia Risks 2Health News:Statement From Stuart L. Weinstein, MD, Chairman, Doctors for Medical Liability Reform on Senator Baucus' Health Care Reform Proposal 2Health News:Public Option Still Viable As House Set to Pass It -- Not 'Fading,' Says Robert Weiner, Former House Aging Committee Director 2Health News:International Isotopes Inc. Announces Successful Completion of a Private Placement 2Health News:International Isotopes Inc. Announces Successful Completion of a Private Placement 3Health News:IPRO Wins Knowledge Transfer/Implementation Federal Contract From AHRQ 2
(Date:8/28/2015)...  Today, in final recognition of the Centers for ... 1-800 Contacts is sharing how to keep lens cases ... who do not properly care for their lens cases ... Most contact lens wearers understand the importance ... case is sometimes overlooked.  When proper steps to clean ...
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015 ... ) has announced the addition of the ... report to their offering. Developed by ... selective prostaglandin receptor agonist which effectively reduces intraocular ... by FDA, latanoprost (under the trade name of ...
(Date:8/28/2015)... 28, 2015 Perrigo Company plc ("Perrigo") (NYSE: ... N.V. ("Mylan") (NASDAQ: MYL ) shareholder vote regarding ... "Our views of Mylan,s offer to Perrigo shareholders have ... our Board,s careful reflection of the value available to ... choices that Mylan has allowed its shareholders to consider," ...
Breaking Medicine Technology:1-800 Contacts Shares Tips on How to Clean Lens Cases 2China Latanoprost Market Investigation Report 2015-2019 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 4Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 5
... The Cleveland Clinic and Valence Health announced today that ... become a clinically integrated network.  This new network, the ... physicians, and more than 1,000 private practitioners in the ... Physician Partnership (CPP), recognized the need to pursue Clinical ...
... Biotechnology, Inc. (OTC Bulletin Board: CSBR ), ... accelerating the development and enhancing the value of oncology ... Chief Financial Officer. Mr. Schonau indicated that he has ... other opportunities. Champions is seeking chief financial officer candidates ...
Cached Medicine Technology:Valence Health Selected by Cleveland Clinic to Support Clinical Integration Program 2Champions' CFO Resigns 2
Large, bright images from a bronchoscope designed for routine examination and treatment....
... The BF-1T40 has been designed with ... versatility in therapeutic applications. This permits the ... including those for electrosurgical procedures. In addition, ... wide field of view and a bright, ...
... High performance fiberoptic imaging from ... ,Olympus has improved its fiberscope range, ... specifications and enhanced image performance. Olympus ... instruments for diagnosis and therapy in ...
... scope designed specifically to enable direct inspection ... suitable for pediatric applications as well. Its ... mere 2.8mm across. As a result, insertion ... with greater ease. And since this sophisticated ...
Medicine Products: