Navigation Links
'Jekyll and Hyde' Factor May Control Insulin Function

Finding could lead to new diabetes treatments, researchers say

MONDAY, March 29 (HealthDay News) -- A "Jekyll and Hyde" protein involved in both insulin action and insulin resistance has been identified by U.S. researchers.

It's long been known that an enzyme called PI 3-kinase plays an important role in the main molecular pathway for insulin signaling in cells.

In tests on cells and genetically modified mice, Joslin Diabetes Center researchers found that a protein (p85) in the PI 3-kinase enzyme drives a pathway with an opposite effect -- triggering a stress response that causes insulin resistance, a precursor to diabetes.

"The p85 protein has a kind of yin-yang effect, functioning both as an important link in insulin action and an important link to insulin resistance," the study's senior author, Dr. C. Ronald Kahn, head of the integrative physiology and metabolism section at Joslin, said in a news release from the center.

The study was published March 28 in Nature Medicine.

There are two protein subunits (p85 and p110) in Pl 3-kinase.

"The p85 molecule is like Dr. Jekyll and Mr. Hyde," Kahn said. "One end of the molecule binds to p110, forming a key pathway that is needed for the metabolic effect of insulin on glucose metabolism. The other end of p85 is doing mischief" by interacting with a protein that causes a stress response that's a major factor in insulin resistance.

The finding may offer new targets for developing drugs that target insulin resistance.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about insulin resistance.

-- Robert Preidt

SOURCE: Joslin Diabetes Center, news release, March 28, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New research identifies modifiable risk factors for heart disease
2. Melatonin precursor stimulates growth factor circuits in brain
3. Growth factor gene shown to be a key to cleft palate
4. Salesforce CRM Users Outperform Past Results by a Factor of at Least 50%
5. Study Shows Cigarette Smoking a Risk Factor for Alzheimer's Disease
6. Early Factors Predict Later-Life Stroke Risk, from the Harvard Health Letter
7. 3 key factors to help children avoid social rejection identified
8. For Heart Health, Focus on Risk Factors
9. Mexican Dental Vacation Sees a Rush Of New Patients: Recession A Factor
10. Transplant guide highlights daily infection risks from factors like pets and food
11. Patient Factors Mar Accuracy of Multi-Detector CT Scans
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
(Date:6/24/2016)... ... , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business ... to $12 an hour by 2020 and then adjusting it yearly to increase at the ... minimum wage, assure the wage floor does not erode again, and make future increases more ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Global MEMS Devices Medical Market Analysis 2016 - Forecast to ... The report contains up to date financial ... reliable analysis. Assessment of major trends with potential impact on ... dive analysis of market segmentation which comprises of sub markets, ...
Breaking Medicine Technology: