Navigation Links
'Jekyll and Hyde' Factor May Control Insulin Function
Date:3/29/2010

Finding could lead to new diabetes treatments, researchers say

MONDAY, March 29 (HealthDay News) -- A "Jekyll and Hyde" protein involved in both insulin action and insulin resistance has been identified by U.S. researchers.

It's long been known that an enzyme called PI 3-kinase plays an important role in the main molecular pathway for insulin signaling in cells.

In tests on cells and genetically modified mice, Joslin Diabetes Center researchers found that a protein (p85) in the PI 3-kinase enzyme drives a pathway with an opposite effect -- triggering a stress response that causes insulin resistance, a precursor to diabetes.

"The p85 protein has a kind of yin-yang effect, functioning both as an important link in insulin action and an important link to insulin resistance," the study's senior author, Dr. C. Ronald Kahn, head of the integrative physiology and metabolism section at Joslin, said in a news release from the center.

The study was published March 28 in Nature Medicine.

There are two protein subunits (p85 and p110) in Pl 3-kinase.

"The p85 molecule is like Dr. Jekyll and Mr. Hyde," Kahn said. "One end of the molecule binds to p110, forming a key pathway that is needed for the metabolic effect of insulin on glucose metabolism. The other end of p85 is doing mischief" by interacting with a protein that causes a stress response that's a major factor in insulin resistance.

The finding may offer new targets for developing drugs that target insulin resistance.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about insulin resistance.



-- Robert Preidt



SOURCE: Joslin Diabetes Center, news release, March 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New research identifies modifiable risk factors for heart disease
2. Melatonin precursor stimulates growth factor circuits in brain
3. Growth factor gene shown to be a key to cleft palate
4. Salesforce CRM Users Outperform Past Results by a Factor of at Least 50%
5. Study Shows Cigarette Smoking a Risk Factor for Alzheimer's Disease
6. Early Factors Predict Later-Life Stroke Risk, from the Harvard Health Letter
7. 3 key factors to help children avoid social rejection identified
8. For Heart Health, Focus on Risk Factors
9. Mexican Dental Vacation Sees a Rush Of New Patients: Recession A Factor
10. Transplant guide highlights daily infection risks from factors like pets and food
11. Patient Factors Mar Accuracy of Multi-Detector CT Scans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... July 24, 2017 , ... Axiad IDS , a leading provider of ... with WALLIX to expand its solution to help government contractors more quickly ... number of ways to address the authentication requirements within NIST SP800-171, but no ...
(Date:7/24/2017)... , ... July 24, 2017 , ... ... fat (adipose) transfer systems announces the issuance of United States Patent Number 9,695,398 ... its adipose filtration technology. The '398 and '324 patents cover methods and ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... solution focused on delivering end-to-end sleep health care at scale, indicates record-breaking ... shows that adherence rates for positive airway pressure (PAP) therapy, the most widely ...
(Date:7/24/2017)... ... July 24, 2017 , ... Committed to eliminating clubfoot as ... 100,000 children in their treatment program. Clubfoot is a pervasive problem in the ... is limited or non-existent. Without intervention, these children are destined to grow up ...
(Date:7/24/2017)... ... 24, 2017 , ... On July 19th, the Chinese Academy ... the awarding ceremony was held successfully in Beijing. The State Health Planning Commission, ... system, and national Chinese medicine experts also attended the event, including more than ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... , July 13, 2017  New York City-based market research ... markets should be aware of.  From new products to new ... detailed in a recently completed study, Potential Pipeline Disruptors ... 1.  Age-Driven Growth - True ... been aware of the impact the growing population and, to ...
(Date:7/12/2017)...  Eli Lilly and Company (NYSE: LLY ) ... resolve pending patent litigation in the U.S. District Court for ... the Cialis ® (tadalafil) unit dose patent. This patent ... part of the agreement, Cialis exclusivity is now expected to ... "The unit dose patent for Cialis is valid and infringed ...
(Date:7/11/2017)... July 11, 2017  Bayer has awarded grants totaling more ... part of its prestigious Bayer Hemophilia Awards Program (BHAP). Four ... Philadelphia and Uniformed Services University of the ... the winners. Grant recipients were announced last night during a ... 2017 Congress, Berlin, Germany . ...
Breaking Medicine Technology: