Navigation Links
'Jekyll and Hyde' Factor May Control Insulin Function
Date:3/29/2010

Finding could lead to new diabetes treatments, researchers say

MONDAY, March 29 (HealthDay News) -- A "Jekyll and Hyde" protein involved in both insulin action and insulin resistance has been identified by U.S. researchers.

It's long been known that an enzyme called PI 3-kinase plays an important role in the main molecular pathway for insulin signaling in cells.

In tests on cells and genetically modified mice, Joslin Diabetes Center researchers found that a protein (p85) in the PI 3-kinase enzyme drives a pathway with an opposite effect -- triggering a stress response that causes insulin resistance, a precursor to diabetes.

"The p85 protein has a kind of yin-yang effect, functioning both as an important link in insulin action and an important link to insulin resistance," the study's senior author, Dr. C. Ronald Kahn, head of the integrative physiology and metabolism section at Joslin, said in a news release from the center.

The study was published March 28 in Nature Medicine.

There are two protein subunits (p85 and p110) in Pl 3-kinase.

"The p85 molecule is like Dr. Jekyll and Mr. Hyde," Kahn said. "One end of the molecule binds to p110, forming a key pathway that is needed for the metabolic effect of insulin on glucose metabolism. The other end of p85 is doing mischief" by interacting with a protein that causes a stress response that's a major factor in insulin resistance.

The finding may offer new targets for developing drugs that target insulin resistance.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about insulin resistance.



-- Robert Preidt



SOURCE: Joslin Diabetes Center, news release, March 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New research identifies modifiable risk factors for heart disease
2. Melatonin precursor stimulates growth factor circuits in brain
3. Growth factor gene shown to be a key to cleft palate
4. Salesforce CRM Users Outperform Past Results by a Factor of at Least 50%
5. Study Shows Cigarette Smoking a Risk Factor for Alzheimer's Disease
6. Early Factors Predict Later-Life Stroke Risk, from the Harvard Health Letter
7. 3 key factors to help children avoid social rejection identified
8. For Heart Health, Focus on Risk Factors
9. Mexican Dental Vacation Sees a Rush Of New Patients: Recession A Factor
10. Transplant guide highlights daily infection risks from factors like pets and food
11. Patient Factors Mar Accuracy of Multi-Detector CT Scans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... Memphis, Tennessee (PRWEB) , ... February 13, 2016 ... ... Louise Herrington School of Nursing with an in-kind gift of a VeinViewer® Vision ... help students as they learn how to start an IV and draw blood, ...
(Date:2/13/2016)... ... 2016 , ... DDi , a Makro company, makes ... its expertise in eClinical Solutions. DDi has built its solution competency with a ... global clients. DDi provides smarter technology for Clinical Development, Regulatory and Enterprise domains ...
(Date:2/12/2016)... ... February 12, 2016 , ... The law firm of Morrow, ... Parishes. The purpose of these scholarships is to encourage applicants to pursue a ... seek employment within these two parishes. , “We have available jobs in St. ...
(Date:2/12/2016)... ... ... CDRH Enforcement Trends: , Back to the Future , Feb. 25, 2016 — 11:00 a.m. ... “Those who don’t learn from history are doomed to repeat it.” , An analysis of ... year. But that takes time. , Take a close look at the warning letters ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... As a ... hectic schedule, a demanding job, and no time to decompress, Rabinowitz found herself drawn ... herself to meditation for its impact on her life, implementing a 20-minute-per-day meditation practice ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Feb. 12, 2016  Diplomat Pharmacy, Inc. (NYSE: DPLO ) is pleased to ... Account Management and Payor Strategies effective Jan. 23, 2016. ... ... ... Diplomat Specialty Pharmacy ...
(Date:2/12/2016)... Inc., a medical device company that pioneered the use of the ... device indicated for fusion for certain disorders of the sacroiliac (SI) ... Contractor (MAC) covering the states of Connecticut , ... Massachusetts , Minnesota , ... Rhode Island , Vermont and ...
(Date:2/12/2016)... and SEOUL, South Korea ... Menarini and Macrogen, Inc. today announced they will ... innovative procedures for precision medicine in cancer. The ... Biosystems, DEPArray™ digital-sorting technology with Macrogen,s high-throughput Next ... certified under the Clinical Laboratory Improvement Amendments (CLIA) ...
Breaking Medicine Technology: