Navigation Links
Jefferson scientists uncover key pathway, potential drug targets in autoinflammatory disease
Date:11/12/2007

(PHILADELPHIA) Molecular biologists at Jeffersons Kimmel Cancer Center in Philadelphia have detailed the cascade of cellular events behind some potentially dangerous autoinflammatory diseases. In doing so, they not only have gained a greater understanding of the disease process, but have also identified new potential drug targets for diseases ranging from arthritis to cancer.

Reporting in the journal Molecular Cell, Emad Alnemri, Ph.D., professor of Biochemistry and Molecular Biology at Jefferson Medical College of Thomas Jefferson University, and his co-workers describe how two proteins called PSTPIP1 and pyrin interact to cause autoinflammatory diseases, inherited diseases characterized by seemingly unprovoked and recurrent attacks of fever and inflammation. Such diseases have been found largely to be caused by defects in proteins that regulate inflammation.

According to Dr. Alnemri, defects in pyrin, for example, have been linked to familial Mediterranean fever, a sometimes fatal disease found in the Mediterranean, Middle East and Europe. Defects in PSTPIP1 have been linked to a rare, autoinflammatory disease called PAPA syndrome. The two proteins apparently worked together in the same inflammatory pathway, but no one understood how these proteins could lead to disease.

Dr. Alnemri and his co-workers figured out how. They found that mutant forms of PSTPIP1 found in patients with PAPA syndrome can turn on pyrin, which eventually leads to activating a potent inflammation-causing protein, IL-1 beta. Once activated, IL-1 beta can cause inflammation, fever and the production of other related substances.

Dr. Alnemri explains, Because mutant PSTPIP1 proteins interact with pyrin much more strongly than normal PSTPIP1, they cause uncontrolled or exaggerated activation of pyrin and consequently more secretion of IL-1 beta in these patients.

These proteins now become potential therapeutic targets, Dr. Alnemri says. For
'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
2. Jefferson immunology researchers halt lethal rabies infection in brain
3. Jefferson radiation oncologists use real-time system to plant seeds against cancer
4. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
5. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
6. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
7. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
8. Jefferson oncologists show focused radiation is effective as surgery against nerve tumor
9. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
10. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
11. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... August 30, 2014 Patients suffering from ... disorder in a new review published by Daily Gossip. ... deal with, so there is no wonder that numerous ... The Natural Vitiligo Treatment is one of the most ... Vitiligo Treatment promises to stop the spread of this ...
(Date:8/30/2014)... Daily Gossip reveals in its recently published review that the ... Sarah Summer, who can perfectly understand what suffering from yeast ... actually had to deal with this disorder, too. Her method ... it, in an all-natural holistic cure program. , So, Sarah ... for yeast infection. The author of this program suffered from ...
(Date:8/30/2014)... Delhi, India (PRWEB) August 30, 2014 ... introduced low cost SEO service for small businesses. , ... or start-ups cannot afford costly search engine optimization service. ... budget of small businesses into account. , On ... said, “We have introduced this low cost SEO service ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 After ... the country for the past several years, Dr. ... Hyperbaric Center have announced a scholarship program for ... announcement follows a meeting held this summer to ... recent years, reporters have shed light on the ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 Seniors Guide, the ... recently that focus on Alzheimer’s Disease, Dementia, and Memory ... to the public of being diagnosed with the Alzheimer’s, inspired ... movie, “I’ll Be Me”. The movie, out on October ... focusing on his diagnosis of the disease – which inspires ...
Breaking Medicine News(10 mins):Health News:Natural Vitiligo Treatment Review Exposes Fast Method for Skin Repigmentation 2Health News:Natural Cure for Yeast Infection Review Exposes New Natural Treatment 2Health News:RBSEO Services Introduces Low Cost SEO Service for Small Businesses 2Health News:Tennessee Hyperbaric Center Offering HBOT Scholarships to Veterans 2Health News:Alzheimer’s Disease and Dementia Focus on Retirement Website SeniorsGuideOnline.com 2
... Stop-smoking services available for all Minnesotans, MINNEAPOLIS, ... can give their mothers and themselves the gift ... opportunity to quit smoking for Mom,or for mothers ... can,help Minnesotans quit smoking, whether it,s on Mother,s ...
... Inc. (OTC,Bulletin Board: AIMM) today reported a net loss ... the three months ended March 31, 2008,compared with net ... and,diluted, for the three months ended March 31, 2007. ... in cash and marketable securities as,compared to $8.8 million ...
... Next week, May 11-17, is National Hospital,Week. Texas ... Texas,hospitals., AUSTIN, Texas, May 9 As ... Week May 11-17, the Texas,Hospital Association is emphasizing ... new section on advance directives.,Consumers can visit ...
... CIGNA HealthCare of Arizona and Catholic,Healthcare West ... plan,members will have in-network access to the ... facilities and providers. The contract covers,Catholic Healthcare ... and Medical Center, Chandler Regional Medical Center, ...
... who take up the habit , , FRIDAY, May 9 (HealthDay ... their everyday conversations with peers helps reduce smoking rates, according ... included almost 11,000 students, ages 12 to 13, at 59 ... schools, certain students were selected to receive training about the ...
... HOPKINTON, Mass., May 9 Alseres,Pharmaceuticals, Inc. (Nasdaq: ... host a,conference call on Thursday, May 15th, 2008 ... March 31, 2008 and discuss other matters related ... To access the conference call, please dial ...
Cached Medicine News:Health News:QUITPLAN(R) Services Can Help Make Mother's Day Smoke-Free 2Health News:AutoImmune Inc. Reports 2008 First Quarter Financial Results 2Health News:AutoImmune Inc. Reports 2008 First Quarter Financial Results 3Health News:Web Site Helps Patients Prepare for Hospital Stay 2Health News:Web Site Helps Patients Prepare for Hospital Stay 3Health News:CIGNA HealthCare of Arizona and Catholic Healthcare West Reach Agreement 2Health News:Training Student Leaders Cuts Peers' Smoking Rates 2Health News:Alseres Pharmaceuticals to Host 2008 First Quarter Conference Call 2Health News:Alseres Pharmaceuticals to Host 2008 First Quarter Conference Call 3
(Date:8/29/2014)... Utah , Aug. 29, 2014  BC Technical, ... has acquired Polaris Medical Imaging, a leader in sales, ... This strategic acquisition allows BC Technical to continue to ... specifically within MR and CT modalities. ... service," said Mark Alvarez , president and CEO ...
(Date:8/29/2014)... Does your doctor know what you,re smoking?  Chances ... marijuana to the over 112,000 currently registered patients under ... the other roughly 20,300+ active physicians listed with the Colorado ... – even though a poll in February 2014 showed 51% ... tried it. "With marijuana legalization underway, every ...
(Date:8/29/2014)... 29, 2014 Diseases largely eradicated in ... are returning. Measles was declared eliminated in 2000, yet ... of August 15—the highest incidence in 20 years. In ... declared whooping cough a problem of "epidemic proportions." ... and dying from these preventable diseases—in part because some ...
Breaking Medicine Technology:BC Technical Acquires Polaris Medical Imaging 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3
... (OMX Nordic: ACTI) presented,pre-clinical results for the ... League Against Rheumatism, <a target="_blank" href=,"http://www.eular.org/">www.eular.org ... data presented show that I-3D has a,significant ... model for rheumatoid arthritis (RA)", commented Sven,Andréasson, ...
... Percent Fewer RA Patients,Reported Job Loss When ... Alone, BARCELONA, Spain, June 15, 2007 /PRNewswire-FirstCall/ ... most common causes of,disability in the Western ... arthritis (RA) patients treated with Abbott's HUMIRA(R),(adalimumab) ...
Cached Medicine Technology:New Positive Pre-clinical Data for Active Biotech's RA Project I-3D 2Three Studies Suggest Abbott's Humira (adalimumab) May Improve Work,Productivity in Patients with Rheumatoid Arthritis 2Three Studies Suggest Abbott's Humira (adalimumab) May Improve Work,Productivity in Patients with Rheumatoid Arthritis 3Three Studies Suggest Abbott's Humira (adalimumab) May Improve Work,Productivity in Patients with Rheumatoid Arthritis 4Three Studies Suggest Abbott's Humira (adalimumab) May Improve Work,Productivity in Patients with Rheumatoid Arthritis 5Three Studies Suggest Abbott's Humira (adalimumab) May Improve Work,Productivity in Patients with Rheumatoid Arthritis 6Three Studies Suggest Abbott's Humira (adalimumab) May Improve Work,Productivity in Patients with Rheumatoid Arthritis 7
... Pick one of our pipettors up and ... and ejector positionsright where they should beeven if ... designed to help avoid repetitive stress injuries caused ... The Palm Of Your Hand Start dispensing ...
... for Unparalleled Comfort Pick one of our ... Notice the trigger and ejector positionsright where they ... pipettors are ergonomically designed to help avoid repetitive ... Productivity In The Palm Of Your Hand ...
... ergonomic solution and best value in high ... action and ultra lightweight design reduce hand ... with long, lever tip ejector , Color ... universal tips or for greater performance use ...
... BioControl multichannel has the same ... channel model. The same universal ... and five single channel tip ... a recharge and storage stand ...
Medicine Products: