Navigation Links
Jefferson scientists see breast cancer gene activity from outside the body

(PHILADELPHIA) Researchers at Jefferson Medical College and Jeffersons Kimmel Cancer Center in Philadelphia have used PET imaging to see hyperactive cancer genes inside breast tumors in laboratory animals, marking the first time such gene activity has been observed from outside the body. This technology might someday help physicians to detect and classify cancer, enabling them to find cancerous breast tumors as early as possible, and determine the appropriate treatment.

Reporting in the Journal of Nuclear Medicine, scientists led by Eric Wickstrom, Ph.D., and Mathew Thakur, Ph.D., used a DNA probe a modified nuclear medicine agent to detect the hyperactivity of CCND1, a common breast cancer gene. The gene is copied thousands of times in most breast cancer cells. The high concentration makes CCND1 copies easier to image with the genetic PET probe. The research team found a much higher concentration of the cancer gene activity in estrogen receptor-positive breast tumors in mice than in normal tissue.

Less than one-fourth of lumps found in mammograms are really cancer, notes Dr. Wickstrom, professor of Biochemistry and Molecular Biology at Jefferson Medical College of Thomas Jefferson University. Our new technique will let us see what is really going on in a suspicious lump. We will see if a lump is malignant or something safe.

Patients with benign lumps could avoid invasive procedures if active cancer genes could be identified from outside the body, says Dr. Thakur, professor of Radiology and Radiation Oncology at Jefferson Medical College. Observing the cancer gene activity of a breast tumor will permit physicians to determine the best way to treat it.

The new technique to visualize sites of cancer gene activity, which the investigators call radiohybridization imaging (RHI), might help physicians find out whether lesions found in mammograms are cancerous or non-cancerous without a biopsy. The genetic imaging agents are intended to find cancer gene activity as quickly as possible and guide the choice of therapy based on which genes are most active.

The American Cancer Society estimates that approximately 40,000 women in this country will die from breast cancer in 2007. Yet, clinical examination and mammography can miss almost half of the breast cancers in women under 40, approximately one-quarter of cancers in women ages 40 to 49 and one-fifth of cancers in women over age 50.

When suspect lumps are discovered, biopsies are necessary to determine if the lumps are cancerous, Dr. Thakur points out. However, more than three-fourths of the lumps are found to be benign. Mammography, an invaluable screening technique, sees shapes but not gene activity. Genetic PET scanning is a minimally invasive, sensitive and specific technique that might detect cancers with high efficiency in adult women and young women without breast compression. The researchers expect that RHI will be tested in clinical trials in suspected cases of breast cancer.

Dr. Wickstrom, Dr. Thakur, and their co-workers have found that RHI works for detecting the activity of other cancer genes in other types of tumors as well. Early detection saves lives, Dr. Thakur says. Several other cancers show characteristic activated genes that we might be able to use for early diagnosis, such as pancreatic cancer, prostate cancer, lymphoma, and colon cancer. The investigators are also exploring genetic agents designed for magnetic resonance imaging and fluorescence imaging.


Contact: Steve Benowitz
Thomas Jefferson University

Related medicine news :

1. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
2. Jefferson immunology researchers halt lethal rabies infection in brain
3. Jefferson radiation oncologists use real-time system to plant seeds against cancer
4. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
5. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
6. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
7. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
8. Jefferson oncologists show focused radiation is effective as surgery against nerve tumor
9. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
10. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
11. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
Post Your Comments:
(Date:10/13/2017)... ... 2017 , ... Lori R. Somekh, founder of the Law Office of ... elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office remain ... to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association ... Featuring a collection of specialty vendors and unique items from across the nation, this ... health and wellness services offered by the VNA. The boutique will be open ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... ORANGE COUNTY, Calif. , Oct. 10, 2017  NDS received ... Mobile  — a medical-grade battery-powered display stand specifically designed for ... aims to transform technology into a clinical solution to support the ... costs. Innovative Design ... NDS ZeroWire Mobile Wireless Solution ...
(Date:10/5/2017)... , Oct. 5, 2017  In response ... of Oral and Maxillofacial Surgeons (AAOMS) released prescribing ... – to be used as a first-line therapy ... Recognizing the ... AAOMS White Paper "Opioid Prescribing: Acute and Postoperative ...
(Date:10/4/2017)... Mass. , Oct. 4, 2017 ... of single-use, self-contained, illuminating medical devices, today announced ... National Health Surveillance Agency (or Agência Nacional de ... The first single-use, cordless surgical retractor with integrated ... provides optimal access, illumination and exposure of a ...
Breaking Medicine Technology: