Navigation Links
Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
Date:10/11/2007

(PHILADELPHIA) A tumor-blocking protein previously implicated in prostate and breast cancer development may also be behind the most aggressive type of pancreatic cancer. Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have discovered that the protein pp32 which normally applies the brakes on a cancer-causing gene is missing in an aggressive form of pancreatic cancer. Though the work is preliminary, the scientists say, the absent protein could eventually become a marker for the disease and a potential drug target.

Scientists led by Jonathan Brody, Ph.D., assistant professor of Surgery, Charles Yeo, M.D., Samuel D. Gross Professor and chair of Surgery and Agnieszka Witkiewicz, M.D., assistant professor of Pathology, Anatomy and Cell Biology, all of Jefferson Medical College of Thomas Jefferson University, have shown in experimental models that without the protein, mutations in the cancer-causing gene K-ras can take over, turning cells cancerous. Adding pp32 to pancreatic cancer cells that have K-ras mutations and lack the protein can slow the growth of these fast-growing cells, leading the scientists to speculate that losing pp32 might be a critical event in determining how aggressively a pancreatic cancer behaves. They report their initial findings online in the journal Modern Pathology.

According to Dr. Brody, previous laboratory and animal studies have shown that pp32 inhibits K-ras-activating gene mutations found in more than 90 percent of all pancreatic cancers and in some early pre-cancerous lesions as well. But in a subset of fast-moving, poorly differentiated pancreatic cancers, the researchers found that pp32 is either reduced or lost, Dr. Brody says. Losing the protein in pre-cancerous lesions could be a marker for an aggressive form of pancreatic cancer.

Its rare to find laboratory studies that parallel what we see in actual pancreatic tumors, Dr. Brody says. Connecting a protein that can inhibit a critical mutation found in almost every pancreatic cancer to the pathology is powerful information. These types of studies can help us understand more about the early development of pancreatic cancer on a molecular level.

If we are able to learn more about this molecule, this may be a potential target that we could turn on in aggressive types of pancreatic cancers, he notes. In theory, if we could find a way to upregulate this molecule in these pancreatic cancers, we may be able to arrest these fast-growing cancer cells as we did in experiments in this study. As we understand its molecular interactions, we could also somehow find the things that regulate it and extend our molecular understanding of this devastating disease.

Pancreatic cancer, the fifth-leading cause of cancer death in this country, takes some 30,000 lives a year. The disease is difficult to treat, particularly because it is frequently detected after it has spread to other areas on the body. Only 4 percent of all individuals with pancreatic cancer live for five years after diagnosis, and approximately 25 percent of those diagnosed with pancreatic cancer who undergo successful surgical removal of their disease live at least that long. But recent figures give new hope: of those who live for five years after surgical resection, some 55 percent will be alive at least another five years.


'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Jefferson Physicians Report on Potentially Fatal Complication of Heart Attack
2. Jefferson Researchers Want to Learn If Heart Defect at Heart of Some Migraines
3. Nobel Prize for Medicine shared by Three scientists
4. Scientists plan human cloning clinic in the United States
5. Scientists crack mechanism of Leptin-Obesity Hormone
6. Scientists use plant hormones to fight cancer
7. American scientists alter gene makeup of babies
8. Expose on eating disorders!! Scientists trace “brain’s eating control center pathway”
9. Scientists found ancient Human Germ Killer
10. Scientists locate key hormone involved in appetite control
11. Scientists open the book of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... ... W.S. Badger Co. Inc ., the maker of certified organic and ... of the best small businesses for new dads by Fatherly, the digital lifestyle guide ... progressive benefits to new parents on the organization’s 2016 Best Places to Work ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... help educate the many who are unaware of the plight of aphasia. In ... run within the “Stroke Awareness” campaign. , The link between stroke and aphasia ...
(Date:5/27/2016)... ... ... With a team of certified experts, Validation Center is ... GMP accreditation, Validation Center is also a registered authority of the international system ... Validation Center is ISO17025 accredited and only offers its clients the latest technology, ...
(Date:5/26/2016)... ... 26, 2016 , ... Intalere, the healthcare industry leader in ... inaugural Member Conference at the Paris Hotel in Las Vegas, Nev., May 17-20, ... America’s healthcare providers. , The conference was highlighted by the announcement of the ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... has a significant negative impact on long-term patient survival, reports a team of ... published online this week in the Journal of Thoracic and Cardiovascular Surgery, provide ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... May 27, 2016 According to ... hypertension is driving ambulatory blood pressure monitoring system market ... and their ability to respond to different pressure rates, ... can lead to various cardiovascular disorders such as heart ... These diseases are growing in prevalence each year. WHO ...
(Date:5/27/2016)... NEW YORK , May 27, 2016 ... with biotechs, drug manufacturers, health insurance companies all falling ... very small healthcare companies. While not often talked about, ... The United States is by ... the world. Advanced Medical Isotope Corp. (OTC: ADMD), Nutranomics ...
(Date:5/26/2016)... , May 26, 2016   ... software and analytics, network solutions and technology-enabled ... announced it entered into a strategic channel ... of outpatient software solutions and revenue cycle ... specialty hospitals and rehabilitation clinics to optimize ...
Breaking Medicine Technology: