Navigation Links
Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
Date:1/10/2008

(PHILADELPHIA) A protein that helps prevent a womans body from rejecting a fetus may also play an important role in enabling pancreatic cancer cells to evade detection by the immune system, allowing them to spread in the body.

Researchers at Jeffersons Kimmel Cancer Center in Philadelphia found that the metastatic cancer cells in the lymph nodes of patients with pancreatic cancer produce enough of the protein, IDO, to essentially wall-off the immune systems T-cells and recruit cells that suppress the immune systems response to the tumor. The findings might mean not only a better way to detect pancreatic cancer spreading to lymph nodes, but also could enhance tumor immune therapy strategies against the fast-moving, deadly disease.

According to Jonathan Brody, Ph.D., assistant professor of Surgery at Jefferson Medical College of Thomas Jefferson University, one way that metastatic cancer cells can survive in nearby lymph nodes is by avoiding the immune system. Evidence from studies by scientists looking at other cancers has indicated that IDO (indolamine 23 dioxygenase) is critical to regulating the immune environment. The Jefferson scientists wanted to know if metastatic pancreatic cancer cells residing in the lymph nodes expressed IDO to avoid being found, and if so, could they target this enzyme with available drugs to prevent the cancer cells from hiding from the immune system.

Dr. Brody, Charles Yeo, M.D., Samuel D. Gross Professor and chair of Surgery at Jefferson Medical College and their co-workers analyzed IDO expression in 14 lymph nodes to which pancreatic cancer cells had spread and compared them to the primary tumors that had not spread in the same patients. In every case, they found greater expression of the IDO protein in the cancerous lymph nodes. They also looked at three cases of lymph node-negative pancreatic cancers, finding little IDO present.

Scientists know that IDO shuts off tryptophan producti
'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Jefferson scientists find protein potential drug target for treatment-resistant prostate cancer
2. Jefferson vascular surgeon heads national trial for torn aorta repair
3. Jefferson neuroscientists find early lead exposure impedes recovery from brain injury
4. Jefferson scientists see breast cancer gene activity from outside the body
5. Jefferson scientists uncover key pathway, potential drug targets in autoinflammatory disease
6. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
7. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
8. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
9. Jefferson oncologists show focused radiation is effective as surgery against nerve tumor
10. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
11. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... CA (PRWEB) August 29, 2014 Recent ... have suggested that Americans today are working longer hours ... overworked and overstressed. APEC Water believes that drinking lots ... a Labor Day Sale on their most popular and ... and healthy. From now until 9/2/2014, customers can save ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Until now, ... (relational tables) or unstructured data (document stores). SQL products ... products have basically managed the wide assortment of unstructured ... to work with Big Data is with a NoSQL ... the various aspects of all Big Data issues. ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Two Kelowna ... raise nearly $22,000 to ship a container filled with classroom ... children’s village in Haiti. , “I ... the children,” says Dr. Debra Matson-Visscher. She and her husband, ... Smiles, have been a big part of New Reality International’s ...
(Date:8/28/2014)... 2014 AltMed , a ... precision to the development and production of medical ... primary location in Sarasota County. , "Sarasota ... total commitment to attracting new industry and the ... David Wright, President and CEO of AltMed. "Their ...
(Date:8/28/2014)... August 29, 2014 Doctors Frank DellaCroce ... Restorative Breast Surgery (CRBS) and the St. ... pleased to announce that board certified surgeon Dr. Craig ... plastic surgeons devoted to reconstructive breast surgery. Blum will ... DellaCroce, Sullivan, Christopher Trahan, and M. Whitten Wise. , ...
Breaking Medicine News(10 mins):Health News:Relax this Labor Day Weekend with Great Savings on Easy-Install, Do-It-Yourself Drinking and Whole House Water Filters 2Health News:Scientel Announces Support for SQL Queries and Relational Tables Within Its Gensonix® NoSQL DB 2Health News:Scientel Announces Support for SQL Queries and Relational Tables Within Its Gensonix® NoSQL DB 3Health News:Scientel Announces Support for SQL Queries and Relational Tables Within Its Gensonix® NoSQL DB 4Health News:From Canada to Haiti: Kelowna Dentists Raise Funds to Ship Supplies to Self-Sustaining Village for Orphans 2Health News:From Canada to Haiti: Kelowna Dentists Raise Funds to Ship Supplies to Self-Sustaining Village for Orphans 3Health News:Sarasota County Approves Zoning for Leading Medical Cannabis Firm AltMed 2Health News:New Plastic Surgeon Joins Center For Restorative Breast Surgery 2
... mild brain injury, blast exposure are affected, study says ... become a common complaint among soldiers who suffered mild ... These headaches tend to be debilitating, mirroring migraines in ... be presented next month at the American Academy of ...
... testing, experts say , , MONDAY, Feb. 23 (HealthDay News) -- ... date shows that vitamin D each and every day is ... the common cold or the flu. , The finding is ... and respiratory infection rates among nearly 19,000 American men and ...
... lab tests , ... Jackson, Wyo. ... first online consumer portal that connects consumers to laboratory testing ... its integration with Google Health™, http://www.Google.com/Health , , ,Consumers ...
... Colo., Feb. 23 University of the Rockies ... for students pursuing a master,s or doctoral degree ... grows, there will be an increasing need for ... where these services are provided," said Dr. Steve ...
... Takeda Pharmaceuticals North America, Inc. today announced that ... pharmacies across the U.S. KAPIDEX, available in 30 ... the U.S. Food and Drug Administration (FDA) for the ... Disease (GERD), the healing of erosive esophagitis (EE) and ...
... Protect Senior Care Letter to Governors Rendell, Douglas Says ... State ProjectsJOPLIN, Mo., Feb. 23 In a new ... (D-PA) and James Douglas (R-VT), the Coalition to Protect ... caregiver advocacy groups, today urged the nation,s Governors to ...
Cached Medicine News:Health News:Many Combat Vets Suffer Severe Headaches Upon Return 2Health News:Many Combat Vets Suffer Severe Headaches Upon Return 3Health News:Too Little Vitamin D May Mean More Colds and Flu 2Health News:Too Little Vitamin D May Mean More Colds and Flu 3Health News:Physicians Wellness Network Offers Online Laboratory Testing Services On Google Health 2Health News:University of the Rockies Introduces Mental Health Administration Specialization for Psych Majors 2Health News:KAPIDEX(TM) (dexlansoprazole) delayed release capsules Now Available for the Treatment of GERD 2Health News:KAPIDEX(TM) (dexlansoprazole) delayed release capsules Now Available for the Treatment of GERD 3Health News:National Caregiver Coalition to National Governors Association: Establish State Task Forces to Monitor Medicaid Spending, Ascertain Funds Going to Protect Seniors 2Health News:National Caregiver Coalition to National Governors Association: Establish State Task Forces to Monitor Medicaid Spending, Ascertain Funds Going to Protect Seniors 3
(Date:8/28/2014)...  Rigrodsky & Long, P.A.: , Do you, ... LCI )? , Did you purchase your shares before ... 2014, inclusive? , Did you lose money in your ... to discuss your rights? Rigrodsky & ... Timothy J. MacFall , announces that a complaint has been filed ...
(Date:8/28/2014)... YORK , Aug. 28, 2014 /PRNewswire/ ... research report is available in its catalogue: ... Forecast 2014-2024 http://www.reportlinker.com/p02332847/Needle-Free-Delivery-Technology-and-Market-Forecast-2014-2024.html ... delivery – discover technological and commercial prospects ... needle-free delivery market? Visiongain,s brand new report ...
(Date:8/28/2014)... 2014 Reportlinker.com announces that a new ... North America Laparoscopes Market Outlook to ... North America Laparoscopes Market Outlook to 2020 ... Laparoscopes Market Outlook to 2020", provides key market ... report provides value, in millions of US dollars, ...
Breaking Medicine Technology:Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 3Needle-Free Delivery: Technology and Market Forecast 2014-2024 2Needle-Free Delivery: Technology and Market Forecast 2014-2024 3Needle-Free Delivery: Technology and Market Forecast 2014-2024 4Needle-Free Delivery: Technology and Market Forecast 2014-2024 5Needle-Free Delivery: Technology and Market Forecast 2014-2024 6Needle-Free Delivery: Technology and Market Forecast 2014-2024 7Needle-Free Delivery: Technology and Market Forecast 2014-2024 8Needle-Free Delivery: Technology and Market Forecast 2014-2024 9Needle-Free Delivery: Technology and Market Forecast 2014-2024 10Needle-Free Delivery: Technology and Market Forecast 2014-2024 11Needle-Free Delivery: Technology and Market Forecast 2014-2024 12Needle-Free Delivery: Technology and Market Forecast 2014-2024 13Needle-Free Delivery: Technology and Market Forecast 2014-2024 14Needle-Free Delivery: Technology and Market Forecast 2014-2024 15Needle-Free Delivery: Technology and Market Forecast 2014-2024 16Needle-Free Delivery: Technology and Market Forecast 2014-2024 17Needle-Free Delivery: Technology and Market Forecast 2014-2024 18North America Laparoscopes Market Outlook to 2020 2North America Laparoscopes Market Outlook to 2020 3North America Laparoscopes Market Outlook to 2020 4North America Laparoscopes Market Outlook to 2020 5North America Laparoscopes Market Outlook to 2020 6North America Laparoscopes Market Outlook to 2020 7North America Laparoscopes Market Outlook to 2020 8North America Laparoscopes Market Outlook to 2020 9North America Laparoscopes Market Outlook to 2020 10North America Laparoscopes Market Outlook to 2020 11
... PHILADELPHIA, Oct. 27, 2011 Surgical facilities are facing ... in case volume, combined with shrinking budgets and lowered ... and find the best value when purchasing surgical ... preference are equally as important as price. ...
... nationwide effort to prevent medication abuse and diversion by ... Blue Cross and Blue Shield Association (BCBSA) is again ... Take-Back Day taking place on Saturday, October 29. ... be misused or abused if they get in the ...
Cached Medicine Technology:American-Made Surgical Instruments Meet the High Demands of Surgical Facilities 2Blue Cross and Blue Shield Association Supports the Drug Enforcement Administration's Nationwide Prescription "Drug Take-Back Day" 2
... new Finnpipette Focus from Thermo ... combine ergonomics with uncompromising performance. ... plate offers a custom fit ... new shorter tip cones allow ...
Inquire...
500L...
... ergonomics, and value!, Comfortable feel ... non-slip, contoured handle , Finer control ... spring action , Completely autoclavable for ... need for recalibration , Easy-to-read precision ...
Medicine Products: