Navigation Links
Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
Date:1/10/2008

(PHILADELPHIA) A protein that helps prevent a womans body from rejecting a fetus may also play an important role in enabling pancreatic cancer cells to evade detection by the immune system, allowing them to spread in the body.

Researchers at Jeffersons Kimmel Cancer Center in Philadelphia found that the metastatic cancer cells in the lymph nodes of patients with pancreatic cancer produce enough of the protein, IDO, to essentially wall-off the immune systems T-cells and recruit cells that suppress the immune systems response to the tumor. The findings might mean not only a better way to detect pancreatic cancer spreading to lymph nodes, but also could enhance tumor immune therapy strategies against the fast-moving, deadly disease.

According to Jonathan Brody, Ph.D., assistant professor of Surgery at Jefferson Medical College of Thomas Jefferson University, one way that metastatic cancer cells can survive in nearby lymph nodes is by avoiding the immune system. Evidence from studies by scientists looking at other cancers has indicated that IDO (indolamine 23 dioxygenase) is critical to regulating the immune environment. The Jefferson scientists wanted to know if metastatic pancreatic cancer cells residing in the lymph nodes expressed IDO to avoid being found, and if so, could they target this enzyme with available drugs to prevent the cancer cells from hiding from the immune system.

Dr. Brody, Charles Yeo, M.D., Samuel D. Gross Professor and chair of Surgery at Jefferson Medical College and their co-workers analyzed IDO expression in 14 lymph nodes to which pancreatic cancer cells had spread and compared them to the primary tumors that had not spread in the same patients. In every case, they found greater expression of the IDO protein in the cancerous lymph nodes. They also looked at three cases of lymph node-negative pancreatic cancers, finding little IDO present.

Scientists know that IDO shuts off tryptophan production in T-cells, putting them in a resting state, and recruits a different type of immune cell called T-regulatory cells, which can inhibit the immune system. If cells are escaping the primary tumor and going into another environment such as the lymph nodes, what are they doing to evade detection by the immune system? says Dr. Brody. These data point to the fact that IDO may play a role in helping cancer cells avoid the immune system. His team reported its findings at the recent meeting of the Southern Surgical Association in Hot Springs, VA. The results have been accepted for publication in the Journal of the American College of Surgeons.

The group also examined pancreatic cancer cell lines in the laboratory for IDO expression. Using antibodies to IDO, they didnt find any IDO expression until they treated the cells with interferon to mimic the conditions in the lymph nodes. The tumor cells were then able to make the enzyme.

Whether or not the cancer has spread to the lymph nodes can affect a patients prognosis, particularly after surgery. While scientists know a great deal about how a pancreatic cancer develops from a pre-cancerous growth into a cancer, they still dont have a clear understanding of how it progresses from a primary cancer to metastatic disease. IDO, Dr. Brody says, may play an important part in the process.

The immune system appears to have a balance that can allow cancer cells to grow but also can detect and destroy them, Brody explains. While IDO is crucial to regulating this balance, too much IDO tips the balance toward an immune suppression, supporting cancer growth.

Dr. Brody notes that IDO inhibitors are available clinically, and these could in theory be used with chemotherapy or perhaps other forms of immune therapy against pancreatic cancer. An inhibitor might be able to activate T-cells to kill cancer cells, for example. Presumably we could give IDO inhibitors up front to patients who we know are lymph node-positive to try to reduce the cancer and possibly convert them to surgical candidates, he explains.

Pancreatic cancer, the fourth-leading cause of cancer death in this country, takes some 33,000 lives a year. The disease is difficult to treat, particularly because it is frequently detected after it has spread to other areas on the body. Only 5 percent of all individuals with pancreatic cancer live for five years after diagnosis, and approximately 25 percent of those diagnosed with pancreatic cancer who undergo successful surgical removal of their disease live at least that long. But recent figures give new hope: of those who live for five years after surgical resection, some 55 percent will be alive at least another five years.


'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Jefferson scientists find protein potential drug target for treatment-resistant prostate cancer
2. Jefferson vascular surgeon heads national trial for torn aorta repair
3. Jefferson neuroscientists find early lead exposure impedes recovery from brain injury
4. Jefferson scientists see breast cancer gene activity from outside the body
5. Jefferson scientists uncover key pathway, potential drug targets in autoinflammatory disease
6. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
7. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
8. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
9. Jefferson oncologists show focused radiation is effective as surgery against nerve tumor
10. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
11. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2017)... ... July 26, 2017 , ... Team Type 1 Foundation, ... medicine for everyone affected by diabetes, is excited to announce the 106 college athletes ... Program. , Established in 2005, the Team Type 1 Foundation has bestowed a ...
(Date:7/26/2017)... BC (PRWEB) , ... July 26, 2017 , ... ... (the “Company” or “Isodiol”) a global cannabis innovator, specializing in the development of ... the period from April 1, 2017 to June 30, 2017. Iso International LLC ...
(Date:7/26/2017)... ... July 26, 2017 , ... The number of adults 65 years or ... ways to improve asthma control in the population are not well described. In a ... Practice), an official journal of the American Academy of Allergy, Asthma & Immunology (AAAAI), ...
(Date:7/25/2017)... MOORE, OK (PRWEB) , ... July 25, 2017 ... ... are proud to announce the launch of their partnership to provide the ... is the first pharmacy-focused platform in the country with the ability to develop ...
(Date:7/25/2017)... ... July 25, 2017 , ... ... provider in the United States, today announced its partnership with financial technology company, ... , The foundation of the solution lies within Hyosung’s superior ATMs, assisted self-service ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... July 21, 2017  Endo International plc (NASDAQ: ... comprehensive review of its manufacturing network, the Company will ... facilities in Huntsville, Alabama . The ... over the next 12 to 18 months. The ... declining volumes of commoditized products and these restructuring actions ...
(Date:7/15/2017)... PHILADELPHIA , July 15, 2017 Enterin Inc., ... compounds to treat Parkinson,s disease (PD), today announced the completion ... included new investors New Ventures III, as well as the ... "We are absolutely thrilled to have the support of New ... of our investors as validation of the potential of our ...
(Date:7/13/2017)... 2017  New York City-based market research firm Kalorama Information ... aware of.  From new products to new costs, to the ... recently completed study, Potential Pipeline Disruptors . ... 1.  Age-Driven Growth - True Impact Moment Arriving ... the impact the growing population and, to a more extreme ...
Breaking Medicine Technology: