Navigation Links
Jefferson scientists' discovery may help explain smoking-pancreatic cancer link
Date:4/14/2008

(PHILADELPHIA) If lung cancer and heart disease arent bad enough, cigarette smokers are also at higher risk for developing, among other things, pancreatic cancer. Now, researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have preliminary evidence indicating one possible reason why. Data being presented April 13, 2008 during the Annual Meeting of the American Association for Cancer Research shows that they have found that nicotine in cigarettes increases the production of a protein that is known to promote cancer cell survival, invasion and spread.

According to Hwyda Arafat, M.D., Ph.D., associate professor of Surgery at Jefferson Medical College of Thomas Jefferson University, the protein, osteopontin, is found in a variety of fluids in the body, such as plasma, cerebrospinal fluid, synovial fluid and breast milk. Osteopontin is also present in different organs and plays an important role during embryonic development. Recent studies have demonstrated that osteopontin levels are significantly higher in the blood and pancreas tissue of pancreatic cancer patients. The protein, when over-produced, can make cancer cells more likely to become metastatic.

Dr. Arafat wanted to see if osteopontin might play a role in the cigarette smoking-pancreatic cancer connection. In collaboration with groups at the University of Nebraska and Rutgers University, Dr. Arafat and her co-workers looked at rats exposed to cigarette smoke and measured the amount of osteopontin in the rat pancreas and blood. They found that the more cigarette smoke to which the rats were exposed, the greater the amount of nicotine in the blood and osteopontin in the pancreas.

The researchers also looked at osteopontin expression in pancreatic cancer cell lines exposed to nicotine, finding that osteopontin expression went up when the cells were exposed to more nicotine. We found that dose-dependently, nicotine increased osteopontin expression not only through transcriptional but also translational (protein secretion) levels in pancreatic cancer cells, Dr. Arafat explains. Pancreas tissue samples from pancreatic cancer patients also showed higher than normal levels of the protein.

Dr. Arafat believes that osteopontin could be a drug target. We are now proposing that perhaps blocking osteopontin can interfere with the progression of pancreatic cancer and other cancers, she says, adding that her team would like to understand more about osteopontins effects on pancreatic cancer cell behavior. Dr. Arafats group now is comparing differences in osteopontin expression between smokers and non-smokers.

For example, if you put the cells with nicotine and block osteopontin, will the cells still be migratory? Is it osteopontin or something else in combination that is at work here?

Pancreatic cancer, the fourth-leading cause of cancer death in this country, takes some 34,000 lives a year. The disease is difficult to treat; it frequently is detected after it has spread. Only 4 percent of individuals with pancreatic cancer live for five years after diagnosis, and about 25 percent of those who undergo successful surgical removal of their disease live at least that long.


'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
2. Jefferson immunology researchers halt lethal rabies infection in brain
3. Jefferson radiation oncologists use real-time system to plant seeds against cancer
4. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
5. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
6. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
7. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
8. Jefferson oncologists show focused radiation is effective as surgery against nerve tumor
9. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
10. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
11. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... Falls Church, VA (PRWEB) , ... January 19, 2017 , ... ... Know to Thrive in 2017, **An FDAnews Webinar**, Jan. 26, 2016 — 1:30 p.m. ... to know about the 21st Century Cures Act in order to thrive this year? ...
(Date:1/19/2017)... Atlanta, Georgia (PRWEB) , ... January 19, 2017 ... ... Reconstructive Surgeons hosts the Atlanta Breast Surgery Symposium, a conference where hundreds of ... latest advancements in breast surgery. Covering topics from cosmetic breast augmentation ...
(Date:1/18/2017)... , ... January 18, 2017 , ... Delaware farmer Rick ... St. Louis, Missouri. , Dickerson, of Laurel, farms about a thousand acres of soybeans, ... yellow squash on contract and pumpkins and other vegetables for the fresh market. He ...
(Date:1/18/2017)... USA; and SHANGHAI, China – , ... ... -- Global public health organization NSF International has certified the ... to NSF/ANSI 53: Drinking Water Treatment Units – Health Effects, ... certification verifies that MicroCeramics’ NanoNose Pitcher Filter System filters the ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... their Vice President of Franchise Development, Paula Turner Pizarro, was recently featured on ... which features the insights of top business leaders from across the globe, provides ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... 18, 2017  Kratom leaves, from a South ... often used to prepare tea-like beverages and commercially ... Americans annually to increase alertness, enhance well-being and ... minor aches and pains. PinneyAssociates, review of the ... assist FDA and DEA in determining the most ...
(Date:1/18/2017)... Colo. , Jan. 18, 2017 Safe ... chain of pharmacies based in Loveland, Colorado ... Prescription Vials (LPVs) in selected Good Day locations.     ... have a cost-effective alternative for secure storage," said ... "For less than the price of a cup of ...
(Date:1/18/2017)... 2017 Invetech, the leading developer of ... therapies , has announced a collaboration agreement with ... starvation" treatments for acute leukemia and other oncology ... Invetech will develop systems to enable the commercial-scale ... technology platform, which uses a novel technology to ...
Breaking Medicine Technology: