Navigation Links
Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis
Date:7/8/2008

and his co-workers showed that DACH1 can commandeer cancer-causing genes and return them to normal. The team found evidence from more than 2,000 breast cancer patients that the more the gene is expressed in breast cancer, the better the patient did, enabling it to predict an individual's prognosis.

Because the researchers knew that DACH1 is lost in such invasive breast cancers that carry poor prognoses, they investigated its potential role in the cancer cells' ability to migrate and invade, the prelude to metastasis. They focused on its effects on cancer-causing oncogenes, such as Ras and Myc.

In a series of experiments, the scientists, led by Dr. Pestell and first author Kongming Wu, Ph.D., assistant professor of Cancer Biology at Jefferson Medical College, looked at the effects of adding DACH1 to breast cells made cancerous by various oncogenes. When they added DACH1 to Ras-induced breast cancer cells, for example, they saw a greater than 75 percent reduction in cell migration. Cells turned cancerous by the oncogene ErbB2 showed a 50 percent drop in migration. Cells made cancerous by Myc also had 50 percent less migration.

The researchers performed a proteomic analysis, testing the expression of many proteins at once to see which might be regulated by DACH1. They found that IL-8 is a critical target of DACH1 that helps regulate breast cancer cell migration and metastasis. In mouse studies, they showed that DACH1 lowered the levels of IL-8 genetic material (mRNA) by approximately 90 percent in cancers caused by Ras.

According to Dr. Wu, the gene for IL-8 is also a known target of Ras, helping recruit the formation of new blood vessels to feed a developing cancer a process called angiogenesis. He notes that it's well known that tumors with high levels of IL-8 have a poorer clinical prognosis.

"The findings suggest an important role for IL-8 in blocking the progression of cancer and metastasis," says Dr. Wu. "Because IL
'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
2. Jefferson immunology researchers halt lethal rabies infection in brain
3. Jefferson radiation oncologists use real-time system to plant seeds against cancer
4. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
5. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
6. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
7. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
8. Jefferson oncologists show focused radiation is effective as surgery against nerve tumor
9. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
10. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
11. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... (PRWEB) January 23, 2015 Angelweddingdress is a ... business invites its customers to follow it on Facebook, Twitter, ... a Valentine’s Day gift. Angelweddingdress draws a lottery every week. ... Sale to Feb. 28, 2015. Click Angelweddingdress homepage ...
(Date:1/22/2015)... January 22, 2015 A new white ... experience and person-centeredness in the long-term care environment as ... across the continuum. The paper, “The Power of Person-Centeredness ... perspectives and practices of the patient, resident and family ...
(Date:1/22/2015)... Joan Lunden, award-winning American journalist, beloved television host, ... 32nd Annual Miami Breast Cancer Conference planned and ... , shares that “a fast-growing, virulent” cancer in her ... not followed up her clean mammogram with an ultrasound. ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Four years since the ... – which coincided with the marriage of Avasa & Matthew Love ... ROAD, which is scheduled for release through White Swan Records on ... that there is a sacred path available to all of us ...
(Date:1/22/2015)... 22, 2015 Compare-autoinsurance.org has released a new blog ... an auto insurance policy . , Some types of ... should check the newly released blog post to see if their ... dangerously damaged vehicles are some of the cars that cannot be ...
Breaking Medicine News(10 mins):Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... , , , ... Vision , , ALEXANDRIA, Va., Sept. 10 ... Grade? finds state laws regarding vision assessments for children entering ... 80 percent of what children learn is through visual processing of ...
... , Without a public option ... reform , , WASHINGTON, Sept. 9 ... President William McNary called on Congress to represent the interests of ... quality, affordable health care reform with a public health insurance option. ...
... WASHINGTON, Sept. 9 Change to Win chair Anna ... Congress on health care reform. , , ... care system that has become a tremendous burden on working families ... act now by implementing comprehensive health care reform that guarantees all ...
... , WASHINGTON, Sept. 9 ... healthcare reform, issues this statement upon conclusion of President Obama,s address ... "The President is right. The time to act is ... healthcare reform since the first day of this 111th Congress. The ...
... As the nation awaits President Obama,s address on health care ... (TPC) sent today a letter to the President seeking his ... the field of health. , , During ... and economic effectiveness of health-related philanthropic activities. In response, ...
... School of Public Health (HSPH) and Brigham and Women,s Hospital ... transmitted infection, Trichomonas vaginalis , and risk ... study appears online on September 9, 2009, on the ... appear in a later print edition. "Prostate cancer is ...
Cached Medicine News:Health News:Children at Risk for Undetected Vision Problems 2Health News:In Letter to President, TPC Highlights Foundation Grants in Health 2Health News:In Letter to President, TPC Highlights Foundation Grants in Health 3Health News:Link found between common sexual infection and risk of aggressive prostate cancer 2
(Date:1/23/2015)... 23, 2015  A new analysis of Centers for Medicare ... data shows that 81 percent of seniors chose lower-cost ... discounts at certain pharmacies. The findings were released by ... are now the foundation of Medicare Part D," said ...
(Date:1/23/2015)... 2015 /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ) is investigating ... Inc. ("Advaxis" or the "Company") (NASDAQ: ADXS ... duties to shareholders. On January 21, 2015, ... that Advaxis had misrepresented the clinical data for its ...
(Date:1/23/2015)... , Jan. 23, 2015  Lixte Biotechnology Holdings, Inc. (OTCQB: LIXT), ... I trial of Lixte,s lead compound, LB‑100, is being conducted, ... John S. Kovach , M.D., the founder and President ... be completed at a single site. Accrual of patients, however, ...
Breaking Medicine Technology:New Analysis: 81 Percent of Medicare Part D Seniors Choose "Preferred Pharmacy" Plans in 2015 2Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 3