Navigation Links
Jefferson researchers receive $3.9 million in Challenge grants
Date:11/3/2009

(PHILADELPHIA) Four researchers from Thomas Jefferson University have received $3.9 million in Challenge grant funds as part of the American Recovery and Reinvestment Act.

The NIH has designated at least $200 million in 2009 - 2010 for this new initiative called the Challenge Grants in Health and Science Research. More than 800 Challenge grants across the country have been funded. This program supports research on "Challenge Topics" which address specific scientific and health research challenges in biomedical and behavioral research that will benefit from significant 2-year jumpstart funds. Challenge Areas, defined by the NIH, focus on specific knowledge gaps, scientific opportunities, new technologies, data generation, or research methods that would benefit from an influx of funds to quickly advance the area in significant ways. The research in these areas should have a high impact in biomedical or behavioral science and/or public health.

Flemming Forsberg, Ph.D., professor of Radiology, will receive $895,000 over two years to study a method of measuring portal venous pressure to aid in the diagnosis and management of portal hypertension, which is defined as elevated internal pressure in the hepatic portal vein.

"Increased pressure in the blood vessels of the liver can lead to significant complications, including internal bleeding and death," Dr. Forsberg said. "An accurate marker for portal hypertension would impact literally millions of Americans with liver disease."

Dr. Forsberg and his study team will study a novel ultrasound technique called subharmonic-aided pressure estimating (SHAPE), which is a noninvasive procedure used in the diagnosis and management of portal hypertension. The SHAPE algorithm will be tested first in canines, and then in 45 human patients that undergo a trans-jugular liver biopsy at Jefferson.

Laura N. Gitlin, Ph.D., director of the Jefferson Center for Applied Research on Aging and Health, will receive $1 million over two years to conduct a cost-effectiveness analysis of an intervention called Beat the Blues, a 10-session home-based intervention to treat depression in older community-dwelling African Americans.

"As the prevalence of late-life depression among older African Americans is high, an economic evaluation of Beat the Blues has great potential for improving the lives of this vulnerable population," Dr. Gitlin said.

Dr. Gitlin and her team will calculate the cost and cost-effectiveness of Beat the Blues, which is being studied in a randomized two-group experimental design. Beat the Blues involves trained social workers who meet with the participants to provide depression education, develop tailored action plans to accomplish behavioral goals and teach stress reduction techniques, among other activities.

Maurizio Pacifici, Ph.D., director of Orthopedic Research, will receive $1 million over two years to study Hereditary Multiple Exostosis Syndrome (HME), a rare autosomal dominant disorder that affects about one in 50,000 children and adolescents. It is associated with bone malignant tumors, and causes growth retardation, continuous pain and limited mobility and fatigue.

"This project will thus provide a renewed sense of hope to patients and families alike that this neglected disease will actively be studied and a cure may one day be found," Dr. Pacifici said.

Dr. Pacifici and his team propose to identify and test mechanisms of HME pathogenesis in animal models. They will then test whether exostosis formation can be prevented by pharmacologic interference with a key growth plate signaling factor called Indian hedgehog. In preliminary studies, this signaling factor was abnormally distributed and its redistribution was followed by exostosis formation.

Scott Waldman, M.D., Ph.D., chairman of the department of Pharmacology and Experimental Therapeutics, will receive $1 million over two years to study the role of a colorectal cancer marker called GUCY2C in detecting occult metastases in African-American patients with the disease. Currently, there are disparities in the outcomes of African-American vs. Caucasian patients diagnosed with early-stage colon cancer.

"We believe that African-American patients might have a higher rate of occult metastases in the lymph nodes," Dr. Waldman said. "We also believe this can be overcome using molecular analyses compared to routine pathological analyses."

Dr. Waldman and his team will conduct a retrospective analysis comparing the results of African-American patients and Caucasian patients diagnosed with early-stage colorectal cancer. They will look at the utility of using GUCY2C as a variable to identify occult metastases in the lymph nodes, and see how the tumor burden of GUCY2C compares between African-American and Caucasian patients.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
2. Jefferson immunology researchers halt lethal rabies infection in brain
3. Jefferson radiation oncologists use real-time system to plant seeds against cancer
4. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
5. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
6. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
7. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
8. Jefferson oncologists show focused radiation is effective as surgery against nerve tumor
9. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
10. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
11. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 27, 2016  VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ... whatever measures required to build a strong and stable ... currently listed on the OTC Markets-pink current trading platform. ... CEO, "We are seeing an anomaly in market trading ... only by the Company, but shareholders and market players ...
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
Breaking Medicine Technology: