Navigation Links
Jefferson researchers mirror human response to bacterial infection and resolution in mice
Date:12/14/2011

lacking their own immune system. This resulted in development of a human immune system in these mice. These "human immune system" (HIS) mice were then infected to gauge response.

According to the authors, an analysis of spleens and lymph nodes revealed that the mice developed a population of B1b-like cells that may have fought off the infection. Researchers also observed that reduction of those B cells resulted in recurrent episodes of bacteremia, the hallmark of relapsing fever.

"The B1b cells in humans had been speculated, but never confirmed," said co-author Timothy L. Manser, Ph.D., Professor and Chair of the Department of Microbiology and Immunology at Jefferson. "We found that in mice, the B1b cell subset is critically important for resolution of this type of bacterial infection."

"This would indicate that there is a functional equivalent of the subset in humans that has not been previously recognized," he added.

The mouse model with relapsing fever recapitulates many of the clinical manifestations of the disease and has previously revealed that T cell-independent antibody responses are required to resolve the bacteria episodes. However, it was not clear whether such protective humoral responses are mounted in humans.

"It's an amazing platform that could be used to really study how the human B1 cells could work against a variety of bacterial and viral infections," said Dr. Alugupalli.


'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Thomas Jefferson University receives Science Centers QED Award for pancreatic cancer research
2. Jefferson researchers study outcomes of carotid artery stenting following prior carotid procedure
3. Jefferson is first academic medical center to offer FDA-approved BRAF mutation for melanoma patients
4. Thomas Jefferson University Hospital cuts Whipple procedure wound infections in half with new measures
5. Jefferson physician named an Educator of the Year by the Assocociation of Residents in Radiation Oncology
6. Thomas Jefferson University Hospital adopts new imaging agent to improve detection of bladder cancer
7. Thomas Jefferson University and hospitals tasked to find new radiation drugs
8. FDA approval of brain aneurysm device gives Jefferson neurosurgeons another life-saving tool
9. Jefferson doctors strengthen case for high-dose radiotherapy technique after radical prostatectomy
10. Kimmel Cancer Center at Jefferson breast cancer symposium features latest in research, treatment
11. Jefferson clinical trial: Can a cholesterol drug prevent colon cancer?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/19/2014)... 20, 2014 Recently, BambooIndustry.com, one of ... its new range of bamboo deckings . Moreover, ... natural items; they are now available at deeply discounted ... it is hard to overstate the significance of online ... to online services. The company’s workers are striving to ...
(Date:10/19/2014)... 20, 2014 This report provides ... Seizure, complete with comparative analysis at various stages, ... (MoA), route of administration (RoA) and molecule type, ... press releases. It also reviews key players involved ... special features on late-stage and discontinued projects. , ...
(Date:10/19/2014)... Recently, Top10BestSEOHosting.com has unveiled its newest ... and HostMonster are the best VPS hosting suppliers ... is the method of partitioning a physical server ... the appearance and capabilities of running on someone’s ... pays close attention to VPS products and related ...
(Date:10/19/2014)... October 20, 2014 SweetDressy.com, a professional ... announced its promotion for long evening dresses . ... the special offer; the current discount is up to ... the industry pioneers in the fashion field. Its dress ... ladies dwelling in various parts of the world. All ...
(Date:10/19/2014)... Stephen T. Greenberg, M.D., with offices in Woodbury, Southampton and ... as one of Long Island’s best cosmetic surgeons. In ... the best provider for Botox injections. Glisten, his Skin & ... best Laser Treatment center on Long Island.* , The voting ... the contest once per day, per IP address. , Stephen ...
Breaking Medicine News(10 mins):Health News:High Quality Bamboo Deckings, New Items Unveiled By BambooIndustry.com 2Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 2Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 3Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 4Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2Health News:Promotion For Beautiful Long Evening Dresses Launched By SweetDressy.com 2Health News:Dr. Stephen T. Greenberg – Nominated for the 10th Consecutive Year for One of Long Island’s Best Cosmetic Surgeons for 2015 by the Long Island Press 2
... new study published by the BMJ suggested that the efficacy of ... not rule out about the important effect of omega 3 fats, ... out the beneficial aspects it has on health. ,Consumption ... and fish oils, and a shorter chain omega 3, found in ...
... World Health Organization (WHO) and UNICEF have announced a ... (ORS) that is designed to minimize the occurrence of ... the health agencies achieve the target of reducing child ... second leading cause of child mortality and kills nearly ...
... A new study has found that the body clock, which ... could be re-set to help people working in swing shifts, ... equipped with a biological clock, a region in the brain ... sleep-wake cycles. A research conducted by Kent State professor David ...
... back and neck pain by spine manipulation appears of little ... and chiropractors in the UK to relieve many different types ... allergies. ,When 16 studies were reviewed it ... spinal manipulation is effective for treating any medical problem. ...
... member of the parliament belonging to the Papua New Guinea parliament ... virus//. He will be the first person in the country to ... unnamed MP could be jailed under a 2003 law that made ... Nation newspaper in Papua New Guinea reported. ,The paper ...
... arrested after it became known that they had cheated the ... superfluous tests that were not mandated and hence was never ... Altadena, in charge of the illegal scheme from 1997 to ... up of Medicare beneficiaries and introducing them to several doctor’s ...
Cached Medicine News:Health News:Efficacy of Omega 3 Fatty Acids Needs Wider Perspective 2Health News:Research demystifies treatment by manipulation of spine by chiropractors in the UK 2
(Date:10/19/2014)... SEATTLE, Wash. , Oct. 20, 2014 ... today that it will report its third quarter 2014 ... close of the U.S. financial markets. Following the announcement, ... conference call to discuss the results and provide a ... PDT). Access to the event can be obtained as ...
(Date:10/18/2014)... WASHINGTON , Oct. 18, 2014  In ... Human Rights Campaign (HRC), the nation,s largest lesbian, ... explicitly endorsed the use of Truvada for Pre-Exposure ... health tool used to prevent the spread of ... is the only brand name anti-HIV drug combination ...
(Date:10/17/2014)... Texas , Oct. 17, 2014  Hanger, Inc. ... plans to report its results of operations for the ... 2014 after the market closes.  A conference call to ... a.m., ET, on Friday, November 7, 2014. Those wishing ... available until Friday, November 14, 2014 by dialing 1-855-859-2056 ...
Breaking Medicine Technology:CTI BioPharma to Report Third Quarter 2014 Financial Results on October 29, 2014 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 3
... blood oxygenation can be an essential element of ... clinical setting is often desirable. In keeping with ... easily used point-of-care devices, recent products from several ... Inc., Lake Forest, Calif., says that its HemoCue ...
... still seem radically innovative in the context of many ... been the norm for many years. In automobile assembly, ... with only occasional human oversight. The result has been ... returns in profit and productivity. These days, only a ...
Cached Medicine Technology:Hemoglobin Testing at the Point of Care 2Hemoglobin Testing at the Point of Care 3Lab Automation Networks Proliferating 2Lab Automation Networks Proliferating 3Lab Automation Networks Proliferating 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: