Navigation Links
Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
Date:10/31/2007

hat while these cells were no longer functioning to repair the damaged disc, under appropriate conditions, they could be activated.

To explore that possibility, he isolated cells from discarded disc tissue that still had the capacity to proliferate. Dr. Risbud notes that under certain conditions, the cells could be encouraged to form bone. In other conditions, the cells would form cartilage or even fat. The tests proved that these cells were indeed dormant disc stem cells. If we are able to stimulate the silent cells in the patient, then it may be possible to repair the ravages of degenerative disc disease without undergoing invasive surgical procedures that may limit the motion of the spine, he says.

According to Dr. Risbud, in earlier work, the researchers found that local conditions in the disc can promote adult stem cells of the bone marrow to acquire characteristics of disc cells. Within the disc, the local conditions are unique in that the oxygen levels are low. These conditions cause the expression of many specialized molecules, including the water-binding proteoglycans. Some of the researchers current experiments focus on the use of adult stem cells to repair the degenerate intervertebral disc.

Shapiro notes that other researchers have taken bone marrow stem cells and have made new bone, cartilage and fat tissue. Our next step is to activate these disc stem cells and get them to repopulate the disc and make proteoglycans and restore the water-binding,

The scientists theorize that because the stem cells exist in the degenerate disk, there may be molecules that are blocking stem cell activity. Something is inhibiting the disc repair process, says Dr. Shapiro. Drs. Shapiro and Risbud agree that new studies are needed to discover the nature of such inhibitory molecules and to find ways to block their activities, promoting natural healing.


'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Jefferson Physicians Report on Potentially Fatal Complication of Heart Attack
2. Jefferson Researchers Want to Learn If Heart Defect at Heart of Some Migraines
3. Researchers urge caution in using ear tube surgery
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Researchers identify the early makers of Neonatal Sepsis
6. OHSU Researchers Announce New Discovery
7. Researchers Identify Gene Connected To Bipolar Disorder
8. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
9. Researchers trick Alzheimers Enzyme
10. Researchers find new HIV hiding place
11. Gene researchers make Malaria-resistant mosquito
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Dennis Thompson HealthDay Reporter ... first confirmed case of Ebola has surfaced in the United ... federal health officials announced late Tuesday. The critically ill ... Dallas, has been diagnosed with the deadly virus, officials ... in a late afternoon news conference. The man is ...
(Date:9/30/2014)... Health Day Reporter TUESDAY, ... who are overweight or obese when diagnosed appear to ... weight-related cancer, new research suggests. , , The finding ... only the potential for developing other cancers associated with ... who reported being overweight or obese prior to diagnosis ...
(Date:9/30/2014)... in 2003 to slow the spiraling costs of drugs ... patients has had no meaningful impact on cancer chemotherapy ... Journal of Clinical Oncology published online today. ... treat colorectal and lung cancers, and did not find ... following the implementation of the recent Medicare law in ...
(Date:9/30/2014)... Sept. 30, 2014 Research by UC Irvine immunologists ... shedding light on a vital process that determines how ... the online version of Nature Immunology , neurology ... other Institute for Immunology colleagues describe a critical mechanism ... into the bloodstream. , A T cell is a ...
(Date:9/30/2014)... Las Vegas, NV (PRWEB) September 30, 2014 ... by certified nutrition specialist and best-selling author Mike Geary that ... and totally transform their body into a fat-burning machine in ... Michaels, prompting an investigative review. , “In our culture ... it can be hard to decipher what is really fact ...
Breaking Medicine News(10 mins):Health News:CDC Confirms First Patient Diagnosed With Ebola in United States 2Health News:CDC Confirms First Patient Diagnosed With Ebola in United States 3Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 2Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 3Health News:Landmark Medicare law had little impact on reducing chemotherapy cost 2Health News:UCI study uncovers important process for immune system development 2Health News:Fat Burning Kitchen: Review Exposes Mike Geary’s 24-Hour Diet Transformation for Helping the Body Burn Fat Through a Natural Diet 2Health News:Fat Burning Kitchen: Review Exposes Mike Geary’s 24-Hour Diet Transformation for Helping the Body Burn Fat Through a Natural Diet 3
... risk of developing obesity. In the current issue of ... colleagues from Witten/Herdecke University describe possible ways to prevent ... 268-75). , There are many reasons that a ... the disability itself, for example, if this includes the ...
... ... Your Story” Diamond Contest. Shenoa will give away a 1-carat diamond ... to win the diamond contestants need only write a short story. Consumer ... is a way to show consumers they are appreciated by Shenoa. ...
... new study shows that a family of molecules called ... many important functions in healthy cells, but that in ... , The research, led by scientists at the Ohio ... and Richard J. Solove Research Institute in collaboration with ...
... mysteries of the animal world: why do females change the ... all year round? Researchers at the University of Gothenburg, Sweden, ... found some of the answers. What can millimetre-long water ... south-west Sweden have to say about animals, winter and summer ...
... from seven founding universities of the Global Alliance of ... at Shanghai Jiao Tong University to hold the 2010 ... Sustainable Urban Solutions. The latter coincides with ... Better Life. Senior representatives discussed the role of technological ...
... parents need more help with lifesaving drug regimens, study ... new study suggests that parents often make mistakes when ... , "Giving these medicines in exactly the right way ... conditions," said study lead author Dr. Kathleen E. Walsh, ...
Cached Medicine News:Health News:ShenoaDiamonds.com Holds Contest to Give Away $5,000 Diamond Ring, Spurred by Online Sales Growth 2Health News:Cancer cells show rewired, fragmented microRNA networks 2Health News:Large caps this spring's must-have for water fleas 2Health News:Global Alliance of Technological Universities (GlobalTech) to tackle 'Grand Challenges' 2Health News:Parent Error Common When Medicating Chronically Ill Kids 2
(Date:9/30/2014)... -- The Eastern European medical device industry is in ... as new medical-device manufacturers are constantly trying to penetrate ... to reduce the cost incurred for placing their products ... effective means to achieve this target. This research service ... and provides profiles of key distributors in ...
(Date:9/30/2014)... , Sept. 30, 2014 Passport Health, ... America , has launched FluFree.com, a website designed ... vaccinations. For 20 years, Passport Health has ... the flu. The launch of FluFree.com is designed to ... and the number of people who actually chose to ...
(Date:9/30/2014)... Ind. , Sept. 30, 2014  The orthopedic specialists ... the nation,s No. 6 orthopedic group by US News ... Active Adults," a series of free, public seminars to ... all over the world come to see the knee ... procedures are now available at Munster Specialty Surgery Center. ...
Breaking Medicine Technology:Medical Technologies Distributor Profiles in Eastern Europe 2Medical Technologies Distributor Profiles in Eastern Europe 3Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 2Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 3"Knee Pain Solutions for Active Adults" Complimentary Seminars Open to the Public 2
... 2011 Actavis, an international generic pharmaceutical company, today ... Extended-Release Tablets, a generic equivalent of Keppra XR®.  Shipping ... US total sales of approximately $161 million for the ... Health.   About Actavis: ...
... iKnowMed Electronic Health Record System (EHR) ... McKesson Specialty Health Solutions for Oncology , ... comprehensive chemotherapy orders workflow management system. Oncologists with both products ... which now automatically communicates with Lynx Mobile. This way, when ...
Cached Medicine Technology:Actavis Launches Generic Keppra XR® Tablets in the U.S. 2iKnowMed™ Integrates with Lynx Mobile® to Advance a Comprehensive Chemotherapy Management System 2iKnowMed™ Integrates with Lynx Mobile® to Advance a Comprehensive Chemotherapy Management System 3
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
Inquire...
For use with Snap-In Snap-Out-II tip inserts. Available in five styles, the Snap-In Snap-Out-II Laparoscopic Instrument Handles offer the broadest range available....
Inquire...
Medicine Products: