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Jefferson oncologists show focused radiation is effective as surgery against nerve tumor
Date:10/30/2007

(PHILADELPHIA) Specifically aimed, stereotactic radiation may be as good as surgery and in some cases, even better in treating benign but potentially devastating brain tumors called non-acoustic schwannomas, according to a study by rradiation oncologists at the Kimmel Cancer Center at Thomas Jefferson University and Thomas Jefferson University Hospital in Philadelphia.

While surgery the standard treatment is effective and the only way to remove the tumor, its tricky and can potentially damage surrounding cranial nerves, including those associated with facial movement, eyesight and hearing. Some non-acoustic schwannomas wrap around various structures in the brain and cannot be completely removed. Treating the tumor with radiation is usually effective, less risky, and the vast majority of tumors do not grow back, notes Maria Werner-Wasik, M.D., associate professor of Radiation Oncology at Jefferson Medical College of Thomas Jefferson University.

Timothy Showalter, M.D., a resident in Radiation Oncology, Dr. Werner-Wasik, David Andrews, M.D., professor of Neurological Surgery at Jefferson Medical College, and their co-workers identified 39 patients with non-acoustic schwannomas who received radiation therapy at Thomas Jefferson University Hospital from 1996 to 2007. Patients either received stereotactic radiosurgery (SRS), which entails precise delivery of a single, focused, high dose of radiation to a specific area of the brain, or fractionated stereotactic radiation (FSR), where treatments are received over days or weeks. Roughly one-half of the patients had surgery to remove part of the tumor before radiation; the other half had only radiation. They found that stereotactic radiation, whether delivered in a single dose or in many doses over time, provided excellent local tumor control.

We found that we can improve the symptoms whether they get a single dose of radiation or several smaller doses, and it seems to be permanen
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Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

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