Navigation Links
Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
Date:11/11/2007

hey saw similar effects from IL-27 in cultured cells that were transferred into nave animals, which then produced significantly milder disease. At the same time, they also showed that IL-27 enhanced the production of IL-10, a crucial anti-inflammatory cytokine.

We previously showed that IL-27 could suppress IL-17, he notes. Here we also show that IL-27 can enhance the production of IL-10. These may both be different and complementary mechanisms by which IL-27 can suppress EAE.

The findings suggest that increasing IL-27 concentrations might raise IL-10 levels, and help quell an over-active immune response. This is the first time that we have direct evidence that by actively giving IL-27 like a drug, we can suppress EAE in mice.

Dr. Rostami explains that after an MS flare-up, patients recover from the disease, though the reasons are poorly understood. We think that one of the ways that recovery from a disease flare-up occurs is that part of the immune system is shut off, suppressing the immune response in the brain. IL-27 appears to be crucial in this process, he says.

The team would like to study MS patients blood samples to see if similar processes are at work, Dr. Rostami notes. If we get similar findings in human disease, then perhaps IL-27 could be used therapeutically as a compound to suppress inflammation in the brains of MS patients.


'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
2. Jefferson immunology researchers halt lethal rabies infection in brain
3. Jefferson radiation oncologists use real-time system to plant seeds against cancer
4. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
5. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
6. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
7. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
8. Jefferson oncologists show focused radiation is effective as surgery against nerve tumor
9. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
10. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
11. New class of RNA molecules may be important in human cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... COLUMBUS, Ohio Heart patients with beliefs about health ... to skip sessions of cardiac rehabilitation, new research suggests. ... number of these beliefs referred to as "irrational ... was associated with lower adherence to a prescribed ... assessed: Doubting the preventive power of the flu vaccine ...
(Date:4/14/2014)... A new study shows that domestic abuse is ... depression and post-traumatic stress disorder (PTSD), in mothers. ... abuse are associated with specific mental health problems. ... Carolina State University, Simon Fraser University and the ... see whether and how intimate partner abuse ...
(Date:4/14/2014)... to treatment guidelines for high-risk bladder cancer, chemotherapy ... in routine clinical practice. The findings are published ... journal of the American Cancer Society. , Clinical ... patients with muscle-invasive bladder cancer who are given ... whether chemotherapy after surgery also improves survival. To ...
(Date:4/13/2014)... force has created a new definition for epilepsy that ... disease. The study published in Epilepsia , a ... League Against Epilepsy (ILAE), provides a greater level of ... unprovoked seizures, and those with one unprovoked seizure and ... , The 2005 report by the ILAE task force ...
(Date:4/11/2014)... there is still no effective medical treatment. In an ... of a schizophrenic person, researchers from the University of ... rats that have been given hallucinogenic drugs. This may ... Seven per cent of the adult population suffers from ... understand the disease, they still do not know what ...
Breaking Medicine News(10 mins):Health News:Irrational health beliefs linked to skipping cardiac rehab sessions 2Health News:Irrational health beliefs linked to skipping cardiac rehab sessions 3Health News:Study links domestic abuse to mental health problems in new mothers 2Health News:New clinical definition for epilepsy improves diagnosis accuracy 2Health News:Protein researches closing in on the mystery of schizophrenia 2Health News:Protein researches closing in on the mystery of schizophrenia 3
... 19 As they rush to save lives in the ... address myths about disaster relief among the American public. Edward ... five myths around disaster relief. , 1. Collecting blankets, shoes ... cost of shipping these items from around the country – let ...
... PORTLAND, Ore. , Jan. 18 To support ... Foundation donated $50,000 to Medical Teams International, a humanitarian ... provide medical assistance to areas throughout the world. The organization has ... , "It is difficult to comprehend the loss of life in ...
... Jan. 18 Tyco International (NYSE: TYC ) ... from continuing operations before special items for the first quarter of fiscal ... or $0.61 to $0.63 per share on a GAAP basis. This ... continuing operations before special items of $0.48 to $0.50 per ...
... from a cost model suggest that expenses for systemic ... rate than inflation, and newer biologically derived treatments are ... report in the January issue of Archives of ... is a chronic autoimmune disease that affects an estimated ...
... urge more doctors to ask simple question of male ... dysfunction is a strong warning sign that a man ... and other cardiovascular problems, a long-running study indicates. , ... Study] risk factors, men with erectile function still had ...
... suggest , MONDAY, Jan. 18 (HealthDay News) -- Appendicitis ... organ isn,t removed quickly, U.S. researchers say in a ... also theorize that viral infections can cause appendicitis. , ... is fast becoming history, thanks to new single-incision surgery ...
Cached Medicine News:Health News:Myths of Disaster Relief 2Health News:Myths of Disaster Relief 3Health News:Regence Foundation Donates $50,000 to Aid Haiti Relief Efforts 2Health News:Tyco International Provides Update on First Quarter 2010 Performance 2Health News:Tyco International Provides Update on First Quarter 2010 Performance 3Health News:Tyco International Provides Update on First Quarter 2010 Performance 4Health News:Tyco International Provides Update on First Quarter 2010 Performance 5Health News:Costs of psoriasis treatments outpace inflation 2Health News:Erectile Dysfunction Predicts Heart Disease 2Health News:Study Questions Need for Emergency Appendectomies 2
(Date:1/15/2014)... , Jan. 15, 2014  Manufacturers, ... and technologies must be able to protect ... (IP). (Logo: http://photos.prnewswire.com/prnh/20130716/CL46586LOGO ... nature of the Medical Device Industry, it ... industry sectors of cases involving IP infringement. ...
(Date:1/15/2014)... , Jan. 15, 2014 The ... as a Medical Fitness Center by the Medical ... health and fitness centers to achieve their full ... the only certified fitness center in the western ... "The certification means the Cadence Fitness & ...
(Date:1/15/2014)... 15, 2014 Reportlinker.com announces that ... in its catalogue: ... Delivery Systems -- Focus on End Users ... STUDY OBJECTIVES A drug delivery ... aspects in today,s growth in the pharmaceutical ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18
The Emit 2000 Digoxin Calibrators are intended for use with the Emit 2000 Digoxin Assay....
... The BD Macro-Vue RPR (Rapid Plasma ... Tear-drop Tests are nontreponemal testing procedures ... described in A Manual of Tests ... this manual are the most widely ...
Agglutination test on slide for qualitative and quantitative determination of Syphilis in serum or plasma....
... quality assurance reagent in assays detecting IgG and ... TOXO IgM), IgG and IgM antibodies to rubella ... IgM antibodies to cytomegalovirus (CMV IgG and IgM), ... virus types 1 and 2 (HSV-1 IgG, HSV-1 ...
Medicine Products: