Navigation Links
Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
Date:11/11/2007

(PHILADELPHIA) An immune system messenger molecule that normally helps quiet inflammation could be an effective tool against multiple sclerosis (MS). Neurology researchers led by Abdolmohamad Rostami, M.D., Ph.D., professor and chair of the Department of Neurology at Jefferson Medical College of Thomas Jefferson University and the Jefferson Hospital for Neuroscience in Philadelphia, have found that the protein interkeukin-27 (IL-27) helped block the onset or reverse symptoms in animals with an MS-like disease.

The results suggest that IL-27 may someday be part of a therapy to temper over-active immune responses, which are thought to be at the heart of MS, an autoimmune disease (in which the body attacks its own tissue) affecting the central nervous system. The Jefferson neuroscientists report their findings November 11, 2007 in the journal Nature Immunology. The paper first appears in an advance online publication.

In MS, one of the most common neurological diseases affecting young adults, the myelin coating of nerve fibers becomes inflamed and scarred. As a result, messages cannot be sent through the nervous system. Dr. Rostamis team was trying to understand the mechanisms of how immune responses damage the myelin sheath and axons in the brain.

They had previously observed that IL-27, a signaling molecule called a cytokine, could suppress IL-17, another cytokine, and inflammation. They also knew that in other MS models, mice that lacked receptors for IL-27 developed excessive inflammation.

Dr. Rostami, who is also director of the Neuroimmunology Laboratory in the Department of Neurology at Jefferson Medical College, Denise Fitzgerald, Ph.D., a postdoctoral research fellow in Dr. Rostamis laboratory, and their colleagues used an animal model of MS called experimental autoimmune encephalomyelitis (EAE) for the investigation.

When the scientists gave IL-27 to the experimental mice, it significantly suppressed active disease. T
'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
2. Jefferson immunology researchers halt lethal rabies infection in brain
3. Jefferson radiation oncologists use real-time system to plant seeds against cancer
4. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
5. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
6. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
7. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
8. Jefferson oncologists show focused radiation is effective as surgery against nerve tumor
9. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
10. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
11. New class of RNA molecules may be important in human cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... San Diego School of Medicine report that older women, ... major loss are more likely to be compassionate toward ... published in this month,s issue of the International ... are associated with better health and well-being as we ... improve the outcomes of individuals whose deficits in compassion ...
(Date:4/17/2014)... 2014U.S. military personnel who served in Iraq and ... brain injury (TBI) were compared to military personnel ... reasons. Differences in measures of overall disability, cognitive ... injury are reported in an article in ... Mary Ann Liebert, Inc., publishers. The article is ...
(Date:4/17/2014)... By discovering a new mechanism that allows blood to ... UC Irvine and the Salk Institute have opened the ... stroke-induced brain damage. , A complex and devastating neurological ... primary reason for disability in the U.S. The blood-brain ... blood-borne material into the brain, causing the permanent deficits ...
(Date:4/17/2014)... research team led by Cesar A. Arias, M.D., Ph.D., ... Houston (UTHealth) has identified a new superbug that caused ... appeared in the April 17 issue of The ... superbug is part of a class of highly-resistant bacteria ... which is a major cause of hospital and community-associated ...
(Date:4/17/2014)... is less than 40 years away from a food ... governments, according to a top scientist at the U.S. ... human history, food production will be limited on a ... energy," said Dr. Fred Davies, senior science advisor for ... become as politically destabilizing by 2050 as energy issues ...
Breaking Medicine News(10 mins):Health News:The ilk of human kindness 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:New MRSA superbug emerges in Brazil 2Health News:Food shortages could be most critical world issue by mid-century 2
... ... of their new, pharmaceutical website, featuring an extensive selection of medications for the treatment ... ... popularly sold medications, with a particular emphasis on Erectile Dysfunction treatments. Erectile dysfunction, ...
... 9 The medical imaging market in Kenya is ... driven by an aging population demanding greater access to ... in the market remain high due to the sizeable ... financial constraints faced by many healthcare institutions in the ...
... 8 The Council for American Medical Innovation applauds President ... of life-threatening illnesses in Muslim nations. , , ... , In his address to the Muslim nation in ... must recognize that education and innovation will be the currency ...
... , SALT LAKE CITY, June 8 Qqest Software Systems ... company,s TimeForce time and attendance software, as well as the ... Colorado GI performs over 5,000 medical procedures each year. Prior ... were using a manual time clock and paper time cards ...
... KUNMING, China, June 8 /PRNewswire-Asia-FirstCall/ ... KUN) ("China Shenghuo" or,the "Company"), which is engaged ... nutritional supplement and cosmetic products,in the People,s Republic ... Amex,LLC (the "NYSE Amex" or "Exchange") has accepted ...
... Attorney General Eric Holder will be honored and deliver brief remarks ... Ceremony on TUESDAY, JUNE 9, 2009 at ... will present the Joel A. Toubin Memorial Award to the Attorney ... Holder , , WHAT: To be honored and ...
Cached Medicine News:Health News:Pro-Medics Launches Its New Line of Male Impotence Treatment Products 2Health News:Frost & Sullivan: Replacement of Old Equipment Boosts Kenyan Medical Imaging Industry 2Health News:Frost & Sullivan: Replacement of Old Equipment Boosts Kenyan Medical Imaging Industry 3Health News:Frost & Sullivan: Replacement of Old Equipment Boosts Kenyan Medical Imaging Industry 4Health News:Council for American Medical Innovation Applauds President Obama's Pledge to Invest in Science, Technology and Health Abroad 2Health News:Colorado Gastroenterology Chooses Qqest's TimeForce, Payroll Services 2Health News:NYSE Amex Accepts China Shenghuo's Compliance Plan for Continued Listing 2Health News:NYSE Amex Accepts China Shenghuo's Compliance Plan for Continued Listing 3
(Date:1/15/2014)... -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, 2013-2015" ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from aging ... China,s orthopedic instrument industry has seen rapid ... from 3.28 billion yuan in 2006 to 9.85 billion ...
(Date:1/15/2014)... Jan. 15, 2014  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... offering. (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ... used on patients in order to treat dental impairments, ...
(Date:1/15/2014)... , Jan. 15, 2014 AARP Foundation today announced it ... adults suffering from the severe cold weather that has gripped ... to helping those in need; so to support these emergency ... up to $250,000, which could mean up to $500,000 in ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
... LLC, through its website lawsuitssettlementfunding.com announced today ... in need of lawsuit cash advances ... leader; however they are striving to set themselves apart ... that they have ramped up their operations involving Avandia ...
... N.C. and THE WOODLANDS, Texas, April 20, 2011 ... affiliate of the United Network of US Oncology ... in the Triangle with locations in Raleigh, North Raleigh, Cary, ... (WROS) from Wake Radiology , the oldest and ...
Cached Medicine Technology:Legal-Bay LLC Announces Opening of Jones Act Lawsuit Funding Division 2Cancer Centers of North Carolina Acquires Wake Radiology Oncology Services of Cary, N.C. 2Cancer Centers of North Carolina Acquires Wake Radiology Oncology Services of Cary, N.C. 3Cancer Centers of North Carolina Acquires Wake Radiology Oncology Services of Cary, N.C. 4Cancer Centers of North Carolina Acquires Wake Radiology Oncology Services of Cary, N.C. 5
... System consists of a two-part curable polyurethane ... inserted into the disc space after the ... then injected with the flowable polymer which ... conforms to the shape and size of ...
... trial for 14 years -- and works! ... employs cutting-edge, patent-pending technology to attain the ... unsurpassed accuracy. The technique traces the amount ... blood to determine gender. Here's how it ...
... FISH pharmDx Kit is a direct fluorescence ... quantitatively determine HER2 gene amplification in formalin-fixed, ... is determined from the ratio between the ... the HER2 gene probe (red signals) and ...
... the age of 3 can choose either the ... same design principle applies to both:, ,Maximize ... aerosol output when the patient exhales using two ... to leave the nebulizer. The result is a ...
Medicine Products: