Navigation Links
Jefferson neuroscientists find early lead exposure impedes recovery from brain injury
Date:12/3/2007

(PHILADELPHIA) Exposure to lead can hinder the brains ability to recover from injury, a recent study in laboratory animals shows. The results have implications for the effects of environmental lead exposure on brain injuries such as stroke, say researchers at Jefferson Medical College, who led the work.

Lead exposure early in life is known to increase the risk for cancer, renal disease, hypertension and cardiovascular disease later in life, and as a result, also increases the risk for stroke and brain damage. Jay Schneider, Ph.D., professor of Pathology, Anatomy and Cell Biology and Neurology at Jefferson Medical College of Thomas Jefferson University in Philadelphia and postdoctoral fellow Emmanuel Decamp, Ph.D., wanted to know if it was possible that lead might alter the potential for plasticity, the ability of the brain to compensate for an injury. They studied young rats that were fed a diet supplemented with lead and compared them to others on a diet without lead. In earlier work in the lab, they found that even brief exposures to lead affected neurotrophic factors in the brain important for growth and maintenance of neurons and their connections.

They ran each group through some simple behavioral tests before causing a small stroke in a specific part of the brain that affected a hind limb. Reporting in the journal NeuroToxicology, Dr. Schneider, who is director of the Parkinsons Disease Research Unit at Thomas Jefferson University, and his group saw significant recovery after a brief period of time in the control group, as compensatory processes take over, though the limb function was not completely back to normal.

In contrast, those animals that were exposed to lead earlier in life had worse outcomes in the same period after the stroke, he says. There was significant difference in the brains ability to compensate for that injury.

Because the study was brief, he says, they dont know if in a longer period of time the lead-exposed animals would catch up in their recovery to the controls. There was some recovery in the lead group, but then it leveled off. The control group continued to get better.

Thats one of the questions we would like to pursue in further studies whether lead exposure slows or attenuates the recovery process after a brain injury, Dr. Schneider notes. Have they recovered as much as they will recover or given more time, would they recover to the same extent" Is lead exposure affecting the rate of recovery or the recovery potential"

According to Dr. Schneider, it is well known that lead exposure had detrimental effects on learning and memory, other forms of brain plasticity. Brain plasticity generally refers to the brains ability to be molded by experience as well as its ability to reorganize anatomically and functionally and recover from injury, Dr. Schneider says. Its why people who have relatively small strokes can recover function. The brain has an innate ability to reorganize and repair itself. Our data suggest that lead exposure may compromise or alter this capacity for remodeling that may impair recovery of function following brain injury.

Next, the group would also like to see if such a trend translates to recovery from other types of injury, such as traumatic brain injury. They would also like to explore the notion that childhood lead exposure increases the risk of a child having a poorer outcome from an acquired brain injury.

Dr. Schneider explains that one important aspect of lead poisoning is impairment of plasticity. The data we have begin to support that, he says. We want to look at the effects of different levels of lead exposure on the outcome from acquired brain injury and see how different types and extents of exposures correspond with the expression of injury and recovery of function. Then, we want to try to nail down the biological processes responsible.


'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
2. Jefferson immunology researchers halt lethal rabies infection in brain
3. Jefferson radiation oncologists use real-time system to plant seeds against cancer
4. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
5. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
6. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
7. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
8. Jefferson oncologists show focused radiation is effective as surgery against nerve tumor
9. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
10. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
11. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... California (PRWEB) , ... June 26, 2016 , ... Pixel ... Cut Pro X. , "Film editors can give their videos a whole new perspective ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Key Pharma News Issue 52" report to their offering. ... need in influenza treatment creates a favourable commercial environment for ... and growing patient base that will serve to drive considerable ... flu vaccine would serve to cap sales considerably, but development ...
Breaking Medicine Technology: