Navigation Links
Jefferson immunology researchers halt lethal rabies infection in brain
Date:9/4/2007

und that the PLSJL mice, which genetically produce less inflammatory-regulating hormone, were less likely to die from the rabies infection, possibly because they are more prone to develop a stronger inflammatory response and more likely to have opened brain barriers. Conversely, they also found that despite a strong immune response, the rabies-infected 129/SvEv mice died and were less likely to have open barriers.

When they gave the PLSJL mice the anti-inflammatory steroid hormone DHEA, the brain inflammation decreased, the barriers permeability lessened, and the death rate more than doubled.

The researchers thought that if some rabies-infected PLSJL mice died because the virus overwhelms the immune system T and B cells already in the brain and CNS, then opening the barrier even more would enable more immune cells to reach CNS tissue and fight the virus. They subsequently gave animals experimental autoimmune encephalitis (EAE), which causes an inflammatory response and the barrier to open. As a result, a higher percentage of animals survived the infection.

Halting rabies in the brain

In the future, one of the things we want to do is tone down the inflammatory response caused by EAE and minimize the pathogenesis, yet deliver immune cells to the CNS, says Dr. Hooper, who is also associate director of Jeffersons Center for Neurovirology. The trick to survival might be to open the barrier and deliver effectors to the CNS.

The data suggest that the CNS cells are developing T and B cells effectively, but that delivery to the CNS is impaired, Dr. Hooper explains. It might mean that the communication between the CNS and the immune system is somehow blocked. Perhaps when the disease gets further along, it triggers certain hormones that prevent the brain barrier from opening in response to immune signals. Were trying to develop a better way to open the barrier and let these immune cells in.

While they would like t
'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Jefferson Physicians Report on Potentially Fatal Complication of Heart Attack
2. Jefferson Researchers Want to Learn If Heart Defect at Heart of Some Migraines
3. Researchers urge caution in using ear tube surgery
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
6. New Hair in 15 Days Could Now Be A Possibility Say Researchers
7. Researchers at Cornell University as been reported using research fund by false claims
8. Researchers trick Alzheimers Enzyme
9. Researchers find new HIV hiding place
10. Gene researchers make Malaria-resistant mosquito
11. Researchers developed world’s smallest toothbrus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... 18, 2015 PHOENIX, ARIZONA – In ... with 11 other secure destruction professionals across the United ... (CSDS). He will now display “CSDS” as a professional ... before the National Association of Information Destruction 2015 Annual ... Grapevine, Texas. Of the 20 people who took the ...
(Date:4/17/2015)... (PRWEB) April 18, 2015 Rosetta Radiology ... facility, rounding out their list of diagnostic imaging services. ... for patients on the Upper East Side of Manhattan. ... at full capacity. The addition of PET-CT, combined with ... physicians the ability to work with patients through several ...
(Date:4/17/2015)... April 17, 2015 Florida Hospital Wesley ... and Florida Hospital Carrollwood were all selected as Top ... located in Pasco County, is ranked number one for ... survey, which was conducted in partnership with an independent ... all-private bed hospital that opened in October of 2012 ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Consumers who ... protection without modifications can now use the Insurance Pros ... life insurance policy rates that are featured by leading ... standard plans that are offered are mixed between three ... 18 to 79. There are now term, universal and ...
(Date:4/17/2015)... 2015 At the end of February ... the “Salute to the Oscars” in the Stardust Penthouse ... overlooking the impressive Los Angeles skyline. These events honoring ... Durkin, LA’s leading producer of sustainable product placement in ... world’s premier providers of eco-friendly and socially conscious products ...
Breaking Medicine News(10 mins):Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 2Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 3Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 4Health News:General Life Insurance Policy Rates Added to Quotation System at Insurance Website Online 2Health News:Choices Recovery Speaks with Dakota Hood of “The Hunger Games” about Addiction in Hollywood 2
... It appears that stroke patients who receive both intravenous ... blood clots and endovascular interventions such as ... likely to recover and have lower chances of dying, ... Research Center at the University of Minnesota Medical School., ...
... documentary from Peabody-Award-winning filmmaker,Joseph Lovett - premieres December ... Trailer available at http://www.blooddetectives.org ., ... conjunction with the American Society of,Hematology (ASH) presents ... on December 19, 2008, at 7:00 PM ET/PT ...
... Puerto Rico and District of Columbia get failing grades , , ... premature birth rates, the United States rates a "D," and ... get failing grades. , That,s the sobering conclusion of the ... , released Wednesday. Not a single state earned an "A." ...
... TORRANCE, Calif., Nov. 12 A study published ... energy drinks can cause,caffeine intoxication. It suggested product ... intoxication include nausea, headache, heart,palpitations, insomnia, anxiety or ... comes from the high levels of caffeine,and sugar ...
... Cycling ... iPhone Apps, ... leader in indoor group cycling, today introduced,the new iSPINNING(TM) fitness application ... time only, is an innovative new,cardio and cycling application that compiles ...
... software MCT-Diabetes, has announced that nationally-recognized diabetes specialist Dr. Steven ... regularly scheduled online column to the MyCareTeam diabetes community. ... ... 2008 -- MyCareTeam, Inc., a leading vendor of Internet-based diabetes ...
Cached Medicine News:Health News:Dual treatment for stroke leads to improved recovery rates, reduced mortality 2Health News:Documentary Examining Deadly Blood Disorders and Lifesaving Research to Premiere on Discovery Health 2Health News:Documentary Examining Deadly Blood Disorders and Lifesaving Research to Premiere on Discovery Health 3Health News:U.S. Gets a 'D' for Preterm Birth Rates 2Health News:Study Calls for Labeling of Potentially Dangerous Energy Drinks 2Health News:Spinning(R) Announces First Heart Rate and Fitness Application for the iPhone(TM) and iPod(R) touch 2Health News:Spinning(R) Announces First Heart Rate and Fitness Application for the iPhone(TM) and iPod(R) touch 3Health News:Nationally Recognized Diabetes Specialist Dr. Steven Edelman to Provide Educational Articles on Diabetes to MyCareTeam's Website Community 2Health News:Nationally Recognized Diabetes Specialist Dr. Steven Edelman to Provide Educational Articles on Diabetes to MyCareTeam's Website Community 3
(Date:4/17/2015)... , Apr. 17, 2015 Research and Markets ... addition of the "Medical Device Outsourcing - ... offering. This report analyzes the worldwide ... by the following Device Categories: Class I, Class ... analyzed in the report Include - Radiology, Orthopedic, ...
(Date:4/17/2015)... 17, 2015  Trovagene, Inc., (NASDAQ:  TROV) a ... clinical data presented at the 2015 European Lung ... Cancer Monitoring ℠ (PCM) platform outperformed tissue ... EGFR T790M mutations in metastatic lung cancer ... T790M Mutation in Urinary Circulating Tumor DNA from ...
(Date:4/17/2015)... Apr. 17, 2015 Steven Rash , the ... and its operating subsidiary American Seed & Oil Company, ... to investors yesterday in New York City.  Mr. Rash,s ... The American Seed & Oil Company has recently announced ... Butter Hemp Seed Foods , the EpiVape , ...
Breaking Medicine Technology:Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 2Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 3Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 2Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 3Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 4American Seed & Oil Company Benchmarks its Consumer Product Development Strategy Against Proctor & Gamble 2American Seed & Oil Company Benchmarks its Consumer Product Development Strategy Against Proctor & Gamble 3
... Pa. , May 3 Unisys Corporation announced today ... information management (HIM) business to Molina Healthcare, Inc. for $135 ... , , ... solutions and business process outsourcing services to state governments for administering ...
... LONDON , May 3, 2010 The ... 2016, but,a familiar name, Pfizer, will still be the biggest seller of ... today,by EvaluatePharma, the premier provider of pharma and biotech analysis. , ... The cancer ...
Cached Medicine Technology:Unisys Completes Sale of Health Information Management Business 2Pfizer Reigns Supreme After Patent Cliff as Humira Kicks Avastin off Top Spot 2Pfizer Reigns Supreme After Patent Cliff as Humira Kicks Avastin off Top Spot 3Pfizer Reigns Supreme After Patent Cliff as Humira Kicks Avastin off Top Spot 4Pfizer Reigns Supreme After Patent Cliff as Humira Kicks Avastin off Top Spot 5
Galaxy IVUS Imaging System simplifies the process of intracardiac echo while delivering accurate, real-time diagnostic information in less time with less work. (Ultra ICE catheter compatible)...
The Duett Pro is simple, precise and efficient. Duett Pro sleeve hub is lightweight and ergonomic. A 'quick connect' feature provides a secure connection of the sleeve hub to the base during catheter...
... VasoSeal VHD was ... rapidly stop bleeding after ... and radiology procedures. It ... sealing device approved for ...
... was the first device ... after diagnostic and interventional ... It is a collagen-based ... for immediate sheath removal ...
Medicine Products: