Navigation Links
Jefferson doctors strengthen case for high-dose radiotherapy technique after radical prostatectomy
Date:4/13/2011

PHILADELPHIAA widely-available yet expensive radiotherapy technique used to treat prostate cancer patients after surgery has promising benefitshigher dose and less damage to the rectum and bladdercompared to a less precise technique, Thomas Jefferson University researchers document for the first time in a new study published in Practical Radiation Oncology.

A team of radiation oncologists and medical physicists, including lead author Amy Harrison, M.S., the medical physics clinical supervisor at Jefferson, show that intensity-modulated radiotherapy (IMRT) allows a higher dose to be delivered to the area after their glands have been removed while maintaining the same dose to the rectum and bladder compared to 3D conformal radiation therapy.

Higher doses to the prostate bed have been shown to be more effective in that setting for controlling prostate-specific antigen (PSA) levels.

IMRT is currently being used at some centers in the United States, including the Kimmel Cancer Center, to treat men after they've had their prostate glands removed, but detailed data are limited evaluating the advantages of this approach compared to 3D conformal radiation therapy. In other words, documented justification for the approach was lacking.

"This is the first contemporary study to look at IMRT versus 3D radiation therapy for post-op patients using consensus guidelines," said Timothy Showalter, M.D., assistant professor of Radiation Oncology at Thomas Jefferson University, and an expert in image-guided therapy of prostate cancer. "This is also filling a gap for information that no one supplied before to show that this radiotherapy is beneficial in the postoperative setting, similar to its role in non-surgical approaches."

"The reason that it's more and more relevant now is that there are emerging data to support doing adjuvant radiation therapy after prostatectomy for high risk patients," he added.

There a variety of toxicities associated with radiation therapy after a prostatectomy, including late gastrointestinal bleeds, loose stools and painful bowel moments, but IMRT can minimize damage that can lead to such side effects.

"The biggest benefit for our patients who have a PSA failure after radical prostatectomy is to be able to deliver high dose radiation while sparing normal tissue," said Dr. Showalter.

Future studies, the researchers report, should determine whether these advantages translate into improved clinical outcomes for prostate cancer patients.


'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Kimmel Cancer Center at Jefferson breast cancer symposium features latest in research, treatment
2. Jefferson clinical trial: Can a cholesterol drug prevent colon cancer?
3. Thomas Jefferson University professor elected AAAS Fellow
4. Jefferson study determines bone marrow stromal stem cells may aid in stroke recovery
5. CancerCare names Jefferson professor Physician of the Year
6. Jefferson urologist awarded Lifetime Achievement Award from Endourological Society
7. Clue to switch of bladder cancer from locally contained to invasive found by Jefferson scientists
8. Jefferson researcher receives 2010 Pancreatic Cancer Action Network-AACR Career Development Award
9. Jefferson physician named 2010 Emergency Department Director of the Year
10. Jefferson surgeon receives outstanding performance award from American College Of Surgeons
11. Doctors Often Wouldnt Follow Their Own Advice: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... As health professionals work to improve their approach to healthcare, ... doing more than filling out a survey; in many cases health professionals and patients ... health care and research on the importance of active engagement with patients and members ...
(Date:10/13/2017)... ... 2017 , ... PurhealthRX , a leading Health and Nutrition Company, is ... to full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing ... easily incorporated into liquid products, while reducing costs to end users. , The team ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the ... published author, William Nowers. Captain Nowers and his wife, Millie, have six children, ... in the Navy. Following his career as a naval aviator and carrier pilot, ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  True Health, a leader ... its effort during National Breast Cancer Awareness month ... risks. Research ... calculated that more than 10 million American women ... in BRCA1 or BRCA2 and have not had testing. ...
(Date:10/5/2017)... 2017  In response to the nationwide opioid ... Surgeons (AAOMS) released prescribing recommendations that urge ibuprofen ... as a first-line therapy to manage a patient,s ... Recognizing the value and importance of ... Prescribing: Acute and Postoperative Pain Management" stresses that ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: