Navigation Links
Jefferson awarded multi-million dollar NIH grant

PHILADELPHIA The Department of Neurology at Jefferson Medical College (JMC) of Thomas Jefferson University has been awarded a multi-million dollar grant from the National Institutes of Health (NIH) for the creation of a center of excellence to study autoimmune diseases from basic science research to its translation into clinical applications. The five-year grant initially totals over $4 million, but could be as much as $10 million by the end of award period. The center is one of nine in the country and the only one in the Pennsylvania.

"Our priority for this award and center is to translate basic science research into practical, clinical applications in autoimmune diseases," said Abdolmohamad Rostami, M.D. Ph.D., professor and chair of the Department of Neurology at JMC and at Thomas Jefferson University Hospital; director of the Multiple Sclerosis and Neuroimmunology Research Laboratory; and director of the new center. "Primarily we will be focusing on multiple sclerosis (MS), and systemic lupus erthematosus (SLE), but we will also be investigating other autoimmune diseases like scleroderma. The center's team will investigate how these diseases are produced, with the ultimate goal of finding new and successful ways to treat them."

Currently, Dr. Rostami is investigating the role of Th17 cells, a pro-inflammatory T-cell subset, in MS and ways to suppress these cells in hope of finding better treatments for the disease. His laboratory has shown that interkeukin-27, a cytokine produced by T-cells, can suppress Th17 cells. They have also shown that IL-27 can block the onset or reverse the disease in animals with MS-like disorder. "It appears that one of the ways that recovery from an MS exacerbation occurs is that part of the immune system is shut off, suppressing the immune response in the brain. IL-27 through suppression of Th17 cells appears to be crucial in this process," said Dr. Rostami.


Contact: Ed Federico
Thomas Jefferson University

Page: 1

Related medicine news :

1. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
2. Jefferson immunology researchers halt lethal rabies infection in brain
3. Jefferson radiation oncologists use real-time system to plant seeds against cancer
4. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
5. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
6. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
7. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
8. Jefferson oncologists show focused radiation is effective as surgery against nerve tumor
9. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
10. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
11. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
Post Your Comments:
(Date:11/24/2015)... ... November 24, 2015 , ... Cancer patients, ... and experiences at a live taping of the next CURE Connections® ... of Gastrointestinal Cancers 2015 Symposium at Georgetown University Hotel & Conference Center in ...
(Date:11/24/2015)... ... November 24, 2015 , ... American Family Care (AFC), the nation’s ... a holiday pop-up clinic located in Metro Atlanta’s North Point Mall. The clinic is ... different way. The location is scheduled to operate through Dec. 24. , Holiday Pop-Up ...
(Date:11/24/2015)... ... 24, 2015 , ... With Thanksgiving right around the corner, holiday travel season ... protect your family and vehicle. , According to the National Highway Traffic Safety Administration, ... is sharing the following safety tips from the NHTSA: , ...
(Date:11/24/2015)... ... ... , LLC launched their Pro Vest, the latest version of their widely popular weight loss ... 10 hours. , The campaign, which will continue to run through Saturday, ... , The PRO Vest provides consumers with a less expensive, one-size fits all comfort option, ...
(Date:11/24/2015)... ... November 24, 2015 , ... Chiropractic student Katie ... (CU-KC), in Overland Park, Kansas. Benson, a fifth-trimester student in the university’s ... Cleveland III on October 16. , “Katie is very excited and greatly appreciative ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... st  Scientific Assembly and Annual Meeting of the Radiological ... in Chicago on Nov-29 th through ... st  Scientific Assembly and Annual Meeting of the Radiological Society of ... Chicago on Nov-29 th through Dec-4 th ... will present its revolutionary whole body CZT digital SPECT/CT solution at ...
(Date:11/24/2015)... 2015 Teledyne DALSA , a Teledyne Technologies ... will introduce its CMOS X-Ray detector for mammography ... to December 3, at McCormick Place in Chicago ... and interventional imaging will be on display in the South ... advanced CMOS X-Ray detectors is the industry benchmark for high ...
(Date:11/24/2015)...  Boston Scientific Corporation (NYSE: BSX ) is ... Conference on December 8, in New York ... president, Investor Relations, will participate in a 30-minute question-and-answer ... a.m. ET. --> Susie Lisa , vice ... session with the host analyst beginning at approximately 8:35 ...
Breaking Medicine Technology: