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Jefferson, Ohio State team find gene signature profile for metastasis
Date:5/30/2008

n certain organs, telling us that these are commonly involved in the metastatic process," says Dr. Baffa.

Because of the ups and downs in miRNA activity, "many miRNAs that are involved in metastasis are not necessarily specific for one organ, but rather are related to the cell acquiring the ability to spread." The researchers also found a direct association between the alterations in some miRNAs and changes in target proteins.

Many of the miRNAs that were overexpressed in primary tumors had previously been reported, he says, confirming that miRNA signatures are useful in classifying tissue origin.

"Now we have to identify which of the miRNAs in the signature are the most important in facilitating metastasis," Dr. Baffa says.


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Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

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