Navigation Links
Jefferson, Ohio State team find gene signature profile for metastasis
Date:5/30/2008

(PHILADELPHIA) A common signature of tiny, specific pieces of non-coding genetic material known as microRNAs (miRNAs) may be directly involved in the spread of cancer to other parts of the body. Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia and Ohio State University Medical Center in Columbus have identified such a signature, made up mostly of overexpressed miRNAs. The findings, reported at the annual meeting of the American Society of Clinical Oncology in Chicago, may represent a novel diagnostic tool in characterizing gene targets in metastatic cancer.

MiRNAs play a number of roles in biological regulation, including development and cell differentiation. When damaged, they can contribute to cancer by either turning on cancer-causing genes or by inhibiting tumor-blocking genes. The ways that MiRNAs are expressed have been used to profile tumor types in humans.

Because miRNAs are involved in cancer development and progression, scientists led by Raffaele Baffa, M.D., associate professor of Urology at Jefferson Medical College of Thomas Jefferson University and Anne Rosenberg, M.D., clinical professor of Surgery at Jefferson Medical College, in collaboration with a research team led by Carlo Croce, M.D., director of Ohio State University's human cancer genetics program and professor and chair of the Department of Molecular Virology, Immunology and Medical Genetics, wanted to see if there was a specific gene signature that characterized metastasis. Usingmicroarray technology to test many genes at once, they compared different organs breast, lung, bladder and colon to see if miRNAs were either increased or decreased in activity. They analyzed the miRNAs in both primary and metastatic tumors from 43 patients, including 13 breast cancers, 10 lung cancers, 10 bladder urothelial cell cancers and 10 colon cancers.

They discovered that some miRNAs are organ-specific. "Some are increased and decreased specifically in certain organs, telling us that these are commonly involved in the metastatic process," says Dr. Baffa.

Because of the ups and downs in miRNA activity, "many miRNAs that are involved in metastasis are not necessarily specific for one organ, but rather are related to the cell acquiring the ability to spread." The researchers also found a direct association between the alterations in some miRNAs and changes in target proteins.

Many of the miRNAs that were overexpressed in primary tumors had previously been reported, he says, confirming that miRNA signatures are useful in classifying tissue origin.

"Now we have to identify which of the miRNAs in the signature are the most important in facilitating metastasis," Dr. Baffa says.


'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Cystic Fibrosis Foundation Hosts Quality Improvement Summit - Caregivers from 15 States and Canada Gather in Hartford for Intensive Learning
2. Ohio State receives $34M NIH grant
3. Minnesota, National Long Term Care Advocates: Pending Bush Medicare Cut Hurts States Rural Seniors
4. IDC awarded Indias largest state government contract for digital radiography systems
5. NIH awards $25M clinical research grant to Indiana U for statewide initiative
6. PA State Health Officials Encourage Smokers to Quit on World No Tobacco Day
7. Type of Tomato Product Determines Power Against Prostate Cancer
8. Dehydrated tomatoes show promise for preventing prostate cancer
9. States Scorecard Finds Big Differences in Kids Health Care
10. No association found between vitamin D concentration in blood and risk of prostate cancer
11. Vitamin D Status Not Associated With Lower Prostate Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating ... Millions of individuals in the United States and Canada wear eyeglasses. Once considered to ... correct vision and make a fashion statement. Even celebrities use glasses as a way ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever ... Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation ... as home to some of the world’s leading providers of cereal and other breakfast ...
(Date:6/26/2016)... ... 26, 2016 , ... PawPaws brand pet supplements owned by Whole ... enhance the health of felines. The formula is all-natural and is made from Chinese ... PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016   Bay Area Lyme ... Dean Center for Tick Borne Illness , ... Rehabilitation, MIT Hacking Medicine, University of California, Berkeley, ... announced the five finalists of Lyme Innovation ... More than 100 scientists, clinicians, researchers, entrepreneurs, and ...
(Date:6/24/2016)... Calif. , June 24, 2016  American Respiratory Labs (ARL), ... is now able to perform sophisticated lung assessments in patients, homes, ... , Inc. Patients are no longer limited to ... EasyOne PRO ® , ARL patients like Jeanne R. of ... in the comfort of her own home. ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: